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CYP2D6/Fluoxetine Pharmacogenomic Lab Test

  • CYP2D6 testing is used to determine potential risk for side effects to antidepressant medication like fluoxetine (Prozac®)

  • Routine CYP2D6 testing for fluoxetine (Prozac®) is usually not done at this time. Your health care provider will decide if this test is appropriate for you

  • Your health care provider evaluates your test results and uses this information, along with your other health information, to make recommendations for appropriate treatment options

CYP2D6 Test Results

What should I do with my test results?

Talk to your health care provider or pharmacist about the results. They may suggest that you:

  • Keep taking a medication
  • Change the dose of a medication
  • Stop taking a medication
  • Take a different medication

What does my CYP2D6 result mean

Poor or
poor to intermediate

Consider an alternative due to an increased risk of drug side effects

Who will see my results?

Only health care professionals, and those individuals to whom you have given permission, see your genetic test results. If you are receiving care at another medical facility, Mayo Clinic recommends you share this information with your other health care providers.

How could the CYP2D6 test result affect my treatment with fluoxetine?

If you have a CYP2D6 gene variant, then your health care provider may suggest you take a different medication or adjust the dose of the current medication.

What is fluoxetine?

Fluoxetine (Prozac®), is an antidepressant. Fluoxetine is used in individuals suffering from depression, panic disorder, OCD (Obsessive Compulsive Disorder), etc.

Which gene affects my response to fluoxetine?

Variants in a gene called CYP2D6, influence the way your body processes (metabolizes) fluoxetine and can affect your response to this medication.

What problems can patients with the CYP2D6 gene variants have when taking fluoxetine?

Patients who have a CYP2D6 gene variant process (metabolize) fluoxetine differently than patients without the gene variant. Talk with your health care provider about other medications that may be a better option for you.

Poor metabolism and poor to intermediate metabolism of this drug by CYP2D6 has been associated with the potential for increased risk of drug side effects.

Where can I find more information about fluoxetine?

More information about fluoxetine you might find helpful includes:

These resources may help you understand more about individualized medicine, genomics and drug-gene testing (pharmacogenomics):

If you have questions about your test results, ask to speak with your health care provider at your Mayo Clinic care location:

  • Minnesota 507-284-2511

  • Arizona 480-301-8000

  • Florida 904-953-2000