PGx Profile Service

Have you ever wondered why some medications may not seem to help you as much as others?

Have you ever changed the dose or stopped taking a medication because you didn't think it worked for you or didn't like the way it made you feel?

Have you ever wanted to know how a medication may affect you before you take it?

These types of questions might be answered by Pharmacogenomics (PGx), which is, the study of how genes affect the body's response to medications. Emerging tools for PGx testing, also referred to as drug-gene testing, can guide your health care provider to tailor your medications based on your genes. This is key to personalizing your health care.

The PGx Profile Service

The PGx Profile Service now is available through Mayo Clinic and includes:

  • A referral and consultation with a PGx pharmacist
  • PGx blood test through a Mayo Clinic lab at a time that works for you
  • Follow-up with the PGx pharmacist to review patient results
  • PGx results recorded in the patient's Mayo Clinic electronic health record for present and future prescription needs
  • A written summary of the PGx results

Within the PGx Profile Service the PGx pharmacist will:

  • Review the patient's current and past medications, including doses, side effects and concerns
  • Explain PGx testing, benefits and limitations and answer questions
  • Interpret PGx results
  • Work with the patient's health care provider to make any necessary changes to current medications; and discuss what it may mean for future medication use

This consult can last up to 1 hour depending on your medication history and current medications.

The PGx blood test includes:

  • A blood draw
  • Analysis of nine important genes related to how the body processes and interacts with a variety of medications
  • PGx results are available in approximately 2-3 weeks


The cost of the PGx Profile Service varies, but can be more than $3000. This includes the lab test as well as the initial PGx pharmacist consultation and follow-up visit.

Insurance Coverage

Some insurance companies may cover PGx testing, depending on the policy and reasons for testing. Patients are advised to contact their insurance provider about coverage prior to testing if this is a concern. Patients may need the diagnosis and billing codes for the specific lab tests from their health care provider before contacting the insurance company.

Key facts about PGx results

  • This will NOT test for drug allergies, drug-drug interactions or drug/food interactions
  • This test cannot explain how a patient will respond to all medications
  • Currently, the test results include over 150 medications, for example:
    • depression medications
    • anti-seizure/nerve medications
    • pain medications
    • blood pressure and heart medications
    • blood thinners
    • cancer drugs
    • stomach acid irritation medications
  • PGx test results become part of a patient's electronic health record and can be used for future medication prescribing.