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The effect of dopamine on vascular permeability as induced by bradykinin (BK), platelet activating factor (PAF), and VPF/VEGF. |
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Gross appearance of angiogenesis on a mouse ear treated with VPF/VEGF. |
Gross appearance of angiogenesis on a mouse ear induced with VPF/VEGF and treated with dopamine. |
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Confocal microscopy of a mouse ear after angiogenic induction by VPF/VEGF.
* = vascuular formations of glomeruloid bodies |
Confocal microscopy of a mouse ear after angiogenic induction by VPF/VEGF and dopamine treatment. |
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Giemsa stained Epon section of mouse ear after angiogenesis induction with VPF/VEGF. |
Giemsa stained Epon section of mouse ear after angiogenic induction with VPF/VEGF and dopamine treatment. |
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M = new enlarged, thin-walled 'mother' vessels
Cart = ear cartilage
Vertical black lines in f. and g. indicate the extent of edema as measured by the thickness of the derma. |
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Gross appearance of angiogenesis in the peritoneal wall of mice after ovarian tumor injection. |
Gross appearance of angiogenesis in the peritoneal wall of mice after ovarian tumor injection and dopamine treatment. |
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Microscopic appearance of peritoneal angiogenesis with an increase in vessel number and size in mice injected with ovarian tumor. |
Near normal microscopic appearance of peritoneal tissues in mouse injected with ovarian tumor and treated with dopamine. |
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Adherent ovarian tumor cells on peritoneal lining tissues (Tu). |
Decreased tumor adhesion on peritoneal lining tissue after dopamine treatment. (black arrows = mesothelial cells activated, white arrows = mononuclear cell infiltrate). |
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Enlarged 'mother' vessel with increased microvascular permeability as determined with the labeling of extravasated colloidal carbon. |
Vessels from dopamine-treated ovarian tumor-bearing mice with no leakage of colloidal carbon. |
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