Dennis Wigle, M.D., Ph.D.

Research in our laboratory is directed along two main project lines:

• Thoracic Oncology: We have a number of basic and translational interests in thoracic malignancies. The application of gene expression biomarkers for the molecular staging of non-small cell lung cancer (NSCLC) is an emerging field with the promise of clinical translation. At a more basic level, we are interested in the molecular steps transforming a normal bronchial epithelial cell through dysplasia to malignancy. A number of modern genomic, proteomic, and mouse transgenic technologies are used in these studies.
• Lung organogenesis: Understanding of the molecular mechanisms involved in growth and development of the normal lung are fundamental to harnessing these processes for clinical tissue regeneration. We use the mouse as a model for this work, and are interested in the potential utility of lung stem cells for regenerative strategies.