LIST OF PROJECTS

Current Studies:

1. "Phase II Trial of IGF-I for Painful Neuropathy, IND 45,793" PI: Dr. A. J. Windebank.
2. "Compassionate Use of 3,4 Diaminopyridine in Presynaptic Disorders of Neuromuscular Transmission" PI: Drs. C. M. Harper, Jr. and A. G. Engel.
3. "Request to Contact Patients to Provide 30 ml of Blood to be Used in Establishing New Antibody Test" PI: Dr. A. J. Windebank.
4. "Request to Harvest Routine Autopsy Material of Spinal Cord Specimens" PI: Dr. A. J. Windebank.
5. "Treatment of Subacute Proximal Diabetic Neuropathy with IVIg BB-IND 6802" with Dr. A. J. Windebank.
6. "A Treatment Protocol Using Myotrophin (Human Mecasermin [Recombinant DNA Origin]) Injection in Patients with Amyotrophic Lateral Sclerosis" PI: Dr. A. J. Windebank.
7. "Dolostatin-10 for Phase II Advanced Renal Cell Carcinoma" PI: Dr. H. C. Pitot.
8. "Phase I Trial of Suramin with Sequential Doxorubicin in Patients with Advanced Solid Tumors" PI: Dr. A. A. Adjei.
9. "A Phase I and Pharmacologic Study of Sequences of Vinorelbine and Paclitaxel in Patients with Advanced Solid Tumors" PI: Dr. A. A. Adjei.
10. "Cisplatin Neurotoxicity" PI: Dr. A. J. Windebank.
11. "Measuring the Interobserver Reliability and Validity Between Different Medical Institutions of Maximal Voluntary Isometric Contraction Megascores (MVIC) and Manual Motor Testing Scores (MMT) in Assessing Progression of ALS" Co-Investigators: Drs. E. L. Feldman (University of Michigan, Ann Arbor, MI), J. R. Mendell (Ohio State University, Columbus, OH), H. Mitsumoto (Cleveland Clinic, Cleveland, OH), D. S. Newman (Henry Ford Hospital, Detroit, MI), E. J. Sorenson (Mayo Clinic, Rochester, MN), and A. J. Windebank (Mayo Clinic, Rochester, MN).
12. "Suramin Neurotoxicity" PI: Dr. J. S. Gill.
13. "Peripheral Neuropathy in Nondiabetic Patients with Hypertriglyceridemia" PI: Dr. C. M. Harper, Jr.

Future Studies:

• "Olmsted County Polio Study, 10 year Follow-Up Study" with Drs. E. J. Sorenson and A. J. Windebank.