Publications

The faculty members of the Center for Individualized Medicine at Mayo Clinic are committed to teaching and facilitating the growth of medical knowledge. Collectively, Mayo authors publish more than 5,000 articles a year in biomedical journals.

Publishing in medical journals is an expected scholarly activity of professional practice and aligns with our value of sharing expertise and best practices to facilitate the advancement of medical practice worldwide.

The topics below provide links to publications authored by Mayo Clinic experts to document their research and clinical expertise in the areas of research related to individualized or personalized medicine.

The links return citations from PubMed, a service of the U.S. National Library of Medicine. PubMed is comprised of references and abstracts from MEDLINE, life science journals and online books:

  • Biobanking. Facilities that collect, store, and distribute tissues, e.g., cell lines, microorganisms, blood, sperm, milk, breast tissue, for use by others. Other uses may include transplantation and comparison of diseased tissues in the identification of cancer.

  • Bioethics. A branch of applied ethics that studies the value implications of practices and developments in life sciences, medicine, and health care.

  • Bioinformatics. A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.

  • Biological Markers. Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development and epidemiologic studies.

  • Biorepositories. Facilities that collect, store, and distribute tissues, e.g., cell lines, microorganisms, blood, sperm, milk, breast tissue, for use by others. Other uses may include transplantation and comparison of diseased tissues in the identification of cancer.

  • Drug-gene testing and alerts. Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity. The introduction of functional (usually cloned) genes into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, liposomes or microcell-mediated gene transfer, electroporation, chromosome-mediated gene transfer, transfection, and genetic transduction.

  • Epigenomics. The systematic study of the global gene expression changes due to epigenetic processes and not due to DNA base sequence changes.

  • Genomics. The systematic study of the complete DNA sequences (genome) of organism.

  • Genetic epigenesis. A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA methylation; histone modification; DNA replication timing; nucleosome positioning; and heterochromatization which result in selective gene expression or repression.

  • Individualized medicine. Clinical, therapeutic and diagnostic approaches to optimal disease management based on individual variations in a patient’s genetic and environmental profi

  • Microbiome. The full collection of microbes (bacteria, fungi, virus, etc.) that naturally exist within a particular biological niche such as an organism, soil or a body of water.

  • Pharmacogenomics. A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism.

  • Precision medicine. How genetic information about a person’s disease is being used to diagnose or treat their disease.

  • Targeted therapy. Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.

  • Whole genome sequencing. The most comprehensive collection of an individual's genetic variation that reveals the complete DNA make-up of an organism and enables a better understanding of variations both within and between species.

  • Whole exome sequencing. The part of the genome that corresponds to the complete complement of exons of an organism or cell.

Alternatively, you can search the Mayo Clinic database using your own search criteria to find recent publications by Mayo Clinic authors.