Multidrug Resistance of Cancer Cells - Xiu-bao Chang

Anticancer Drug Transport

How does the MRP1 protein couple ATP binding/hydrolysis to anticancer drug transport? Several papers have been published, regarding the ATP binding/hydrolysis at those two non-equivalent nucleotide binding domains and conformational changes of the MRP1 protein induced by the ATP binding/hydrolysis. The effects of drug binding on the ATP binding/hydrolysis were also studied. A lot of mutations affecting ATP binding or hydrolysis have been made and used to study the mechanism of ATP-dependent anticancer drug transport. This kind of research is still ongoing.