News, Publications, and Related Stories
Los Angeles Times -- Dec. 12, 2009 Lead researcher: Edith Perez, M.D., Mayo Clinic in Jacksonville, Fla. View Related 
National Cancer Institute (NCI) Cancer Bulletin -- Oct. 6, 2009 Mayo Clinic's Julian Molina, M.D., Ph.D., was among 11 honored. View Related 
Publication: The Journal of Clinical Investigation -- September 2009 
Offering cancer patients in Florida and the Southeast access to investigational therapies through rigorously monitored clinical trials "The cancer field is rapidly moving to use of these new agents as a way to improve upon the success we have seen with more traditional therapies, such as chemotherapy and radiation," says says Michael Menefee, M.D., who heads the Phase I Clinical Trial Program in Oncology at Mayo Clinic, Jacksonville. View Related 
Bret Friday, M.D., of the Duluth, Minn., membership will work with Mayo Clinic and other NCCTG researchers in the development and conduct of neuro-oncology clinical trials View Related 
Mayo Clinic Cancer Center receives an additional five years of National Cancer Institute (NCI) funding and re-designation as a comprehensive cancer center. 
Study findings presented Saturday, May 30, at the American Society of Clinical Oncology annual meeting in Orlando. View Abstract 
Presented at the American Society of Clinical Oncology (ASCO) "The benefits were striking in many patients to a degree we have not previously seen in thyroid cancer in response to other therapies, including the standard treatment of radioiodine," says Keith Bible, M.D., Ph.D., a medical oncologist and researcher who led the multicenter clinical trial funded by the National Cancer Institute. View Abstract 
Presented at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO). A combination of capecitabine, vinorelbine, and trastuzumab offers a treatment option that is at least as beneficial as other current options — and doesn't cause hair loss in patients. View Abstract 
Presented at the American Association for Cancer Research (AACR). The finding is particularly significant, says the study's first author, Mamta Gupta, Ph.D., because the three cell lines studied were all resistant to the effects of chemotherapy - as are many pancreatic tumors - and because the drugs studied are already available for treatment of patients. View Related 
Discovery's Edge Tamoxifen is an anti–estrogen drug that almost halves the return of cancer and reduces the mortality rate by one–third in women with early breast cancer. It is so effective that it has achieved status as somewhat of a miracle drug. However, there is a large group of women who have been taking tamoxifen who might as well have been taking a sugar pill. Three Mayo research teams are collaborating to find the best drugs for these patients. View Related
Presented at the annual San Antonio Breast Cancer Symposium. "These new results validate our earlier findings," says the study's lead investigator, Matthew Goetz, M.D., an assistant professor of oncology and pharmacology at Mayo Clinic, "and strongly suggest that going forward, postmenopausal patients being considered for tamoxifen therapy should be tested for CYP2D6 before beginning therapy." View Related 
The Gores lab has furthered the understanding of how death receptors trigger the demise of liver cells. View Related 
"Tamoxifen is a good drug, but it looks like aromatase inhibitors may be somewhat better," says James Ingle, M.D., a professor of oncology at Mayo Clinic, who presented the results on behalf of the Aromatase Inhibitors Overview Group (AIOG). Presented at the 2008 San Antonio Breast Cancer Symposium. View Abstract 
Presented at the annual San Antonio Breast Cancer Symposium. "Tens of thousands of women in this country are prescribed tamoxifen for either treatment or prevention of breast cancer, and while it has shown remarkable success, it does not work for a substantial number of patients," says the study's lead investigator, John Hawse, Ph.D. "These findings increase our understanding of tamoxifen and, we hope, could pave the way for improved therapies." View Related
Presented at the annual meeting of the American Society of Hematology (ASH). "These are high remission rates, and they happened quickly," says Martha Lacy, M.D., Mayo Clinic hematologist and lead researcher on the study. Also encouraging, says Dr. Lacy, is that treatment did not cause significant side effects in most patients. View Abstract
Publication: The Journal of Cell Biology -- Nov. 17, 2008 
William C. Rupp, M.D., has been appointed CEO for the Florida campus effective Nov. 21, Mayo Clinic announced today. Rupp currently leads quality projects for Luther Midelfort, part of Mayo Health System, as well as Mayo Clinic. 
"We believe this new approach is better for patients because it identifies those who will develop aggressive CLL sooner than later and helps delay need for more toxic treatments," says study lead investigator Clive Zent, M.D., a Mayo hematologist. View Abstract 
Mouse study shows dopamine blocks tumor-feeding blood vessels "Sometimes new drugs may not be the answer. We looked instead at a novel use for an established product and have found very promising results," says Mayo Clinic oncology researcher Sujit Basu, M.D., Ph.D. View Related
Agreement strengthens relationship and spawns new scientific collaborations "TGen takes seriously our commitment to work toward helping patients with cancer and other disorders. This announcement is another mechanism allowing TGen and Mayo faculty to work bi-directionally in a more seamless fashion," said Jeffrey Trent, Ph.D., TGen's president and scientific director. View Related 
Presented at the American Society of Hematology's 2007 meeting "In this study we were hoping to find that a lower dose of steroids would be just as effective," says Vincent Rajkumar, M.D., Mayo Clinic Cancer Center hematologist and lead investigator of the study. "We were surprised to find that the regimen with high-dose steroids actually was decreasing survival, besides contributing to increased side effects." View Related
Phase 2 Consortium clinical trial shows promising results Presented by the study's primary investigator, Keith Bible, M.D., Ph.D., at the Molecular Targets and Cancer Therapeutics International Conference, a jointly-sponsored symposium of the American Association for Cancer Research, National Cancer Institute and the European Organization for Research and Treatment of Cancer. "We are encouraged by the interim results of this trial," says Dr. Bible, a medical oncologist and researcher at Mayo Clinic. "Platinum-resistant ovarian cancer responds poorly to traditional therapies, and we've been working toward developing more effective treatments for this disease. This combination looks very promising." View Abstract 
Medical Edge Radio For more information on inflammatory breast cancer treatment at Mayo Clinic, visit http://www.mayoclinic.org/inflammatory-breast-cancer Read Script
Publication: Journal of Clinical Oncology -- June 4, 2007 A Final Report of the AIO Colorectal Study Group (Association of Medical Oncology within the German Cancer Society) View Related 
Mayo Clinic Cancer Center had researchers from many disciplines presenting more than 60 oral abstracts and dozens of posters, also educational sessions and other special events throughout the 2007 ASCO program, June 1-5. View Related
The National Institutes of Health chose Mayo Clinic as one of the first 12 institutions to receive Clinical and Translational Science Awards (CTSA) in October 2006. "There are two objects in medical education: to heal the sick and advance the science." - Dr. Charles H. Mayo 
Yuan-Ping Pang, Ph.D. established the Computer-Aided Molecular Design Laboratory (CAMDL) to learn more about how biological systems function and to establish models that could lead to new treatments for infectious diseases and cancer. View Related 
Multiple myeloma is the second most common blood cancer in the United States after lymphoma, yet no new treatments have been developed in a generation. "Our goal is to deliver individualized care based on the latest genomic information and drugs available," Dr. Lief Bergsagel says. "We intend to find ways to offer the right drug to the right patient each time. And we're set to be among the first to make it happen for patients with multiple myeloma." View Related 
Osteoporosis was not even considered a disease before Mayo Clinic's 1980s groundbreaking epidemiology studies. Funded by a $1.2 million per year NIH Program Project grant, the osteoporosis research team is also taking their research to the genetic and molecular levels to study the physiology of bone metabolism in an aging population. Their studies investigate the TGF-beta-Inducible Early Gene (TIEG) gene's role in bone and skeletal disorders such as osteoporosis and breast cancer metastasis to the bone. View Related 
Clinical Trial Stopped Early Because of Very Positive Results in Treatment Arm A large clinical trial has been halted early because gastrointestinal stromal tumor patients taking Gleevec after surgery did so much better than patients who did not take the drug. The Phase III trial was conducted by the American College of Surgeons Oncology Group (ACOSOG), an NCI Cooperative Group, in collaboration with Cancer and Leukemia Group B, South West Oncology Group, Eastern Cooperative Oncology Group, and National Cancer Institute of Canada Clinical Trials Group. ACOSOG is led by Group Co-chairs Dr David Ota of the Duke Clinical Research Institute, the site of the operations office, and Dr Heidi Nelson of the Mayo Clinic Cancer Center, the site of the Biostatistics. View Related 
Publication: Journal of Supportive Oncology -- March 2007 North Central Cancer Treatment Group in conjunction with Mayo Clinic Cancer Center View Related 
Publication: Mayo Clinic Proceedings -- March 2007 The purpose of this consensus is to offer a simplified, evidence-based algorithm of decision making for patients with newly diagnosed myeloma. In cases in which evidence is lacking, our team of 18 Mayo Clinic myeloma experts reached a consensus on what therapy could generally be recommended. The focal point of our strategy revolves around risk stratification. Although a multitude of risk factors have been identified throughout the years, including age, tumor burden, renal function, lactate dehydrogenase, beta2-microglobulin, and serum albumin, our group has now recognized and endorsed a genetic stratification and patient functional status for treatment. View Related
Custom-fitting a Drug for a Child with Leukemia Some 20 years ago, Mayo Clinic researcher Richard Weinshilboum, M.D., and colleagues made a groundbreaking discovery: They determined why a dose of a drug that could produce astonishing cures in a lethal childhood cancer sometimes also could produce side effects that killed children. The reason behind this strikingly individual response to a drug was found in the genes. With this profound insight into the role that a patient's genetic make-up plays in how the patient responds to a drug, the new field of pharmacogenomic medicine was born. It continues to grow today—Mayo Clinic research leading the way discovering new treatment applications that range from depression, to breast cancer, to chemical dependency. View Related 
Tim Stepanek passed away in January 2006 after a long and heroic battle with amyloidosis and multiple myeloma. His family hopes that Tim's story will inspire others help support research to find new ways to diagnose, treat and prevent amyloidosis. "I think the important thing for me and for them [researchers] was to connect it with a patient. They work very, very hard – way over 40 hours a week. They don't often get the benefit of connecting the practical aspects of what they're doing with the reality of patients' lives. That's the exciting thing." Tim Stepanek View Related
Publication: Science -- Oct. 13, 2006 Biochemistry and Molecular Biology department researchers report that a protein that initiates a “quality control check” during cell division also directs cell death for those cells damaged during duplication. View Related 
The Clinical Research Training Program provides a formal education in all aspects of clinical research, including grant-writing, legal and ethical issues, statistics, epidemiology and study design and protocols. "I realized how exciting research can be, and how exciting it is to advance the science." Jon Ebbert, M.D. View Related 
Publication: Journal of Clinical Oncology -- Aug. 20, 2006 North Central Cancer Treatment Group along with Southwest Oncology Group View Related
Publication: Journal of Clinical Oncology -- Aug. 1, 2006 A companion study to the National Cancer Institute of Canada Clinical Trials Group study MA.17 View Related 
In helping young investigators, Mayo Clinic again is connecting all the dots -- leading back to the same point, the same mission, ongoing and yet unchanged for over a century: the needs of the patient come first. New, young investigators are critical to biomedical research. Their fresh ideas, innovativeness, and enthusiasm are necessary for scientific progress. Yet the steps from a junior research position toward a self-sufficient laboratory can be difficult. Mayo Clinic is dedicated to fostering future, investigators. Here we look at two of them and what Mayo is doing to help. View Related
In scientific literature, epidemiologic studies have linked reduced rates of certain cancers to cultures in Asia where green tea is a popular drink. Legend has it that the Chinese Emperor Shen Nung discovered tea around 2737 B.C.E. He was known as the Divine Healer, and that title is almost all one needs to know about why legends, right or wrong, persist. Green tea has come down through the ages, trailing behind it mythic tales of health benefits from "cheering the heart" to reducing inflammation, from improving bladder function to treating tumors. View Related
Medical Edge Television: Read script (http://www.mayoclinic.org/medical-edge-television-2006/2006-oct-05.html) Medical Edge Television
Mayo Clinic’s Molecular Medicine Program has three gene therapy clinical trials open in which the entire preclinical cycle—concept, discovery of agent, vector manufacture, toxicology and efficacy studies, and new drug application—was conducted at Mayo The projects engineered strains of the measles virus, MV-CEA and MV-NIS, which kill multiple cancer cells, and can be monitored easily. The open trials are in ovarian cancer, glioblastoma multiforme (brain cancer), and multiple myeloma. This article discusses the general research and the first trial which opened -- ovarian cancer. The projects are a fine example of a clear translational effort from bedside to bench and back to the bedside.
Publication: Journal of Clinical Oncology -- Dec. 20, 2005 Results of a pooled analysis from the North Central Cancer Treatment Group View Related 
Publication: Journal of Clinical Oncology -- Dec. 20, 2005 A North Central Cancer Treatment Group Phase II study View Related
Publication: Journal of Clinical Oncology -- Aug. 10, 2005 A North Central Cancer Treatment Group Study View Related
Gemcitabine and ISIS-2503 for patients with locally advanced or metastatic pancreatic adenocarcinoma
Publication: Journal of Clinical Oncology -- Dec. 15, 2004 North Central Cancer Treatment Group clinical trial View Related
Publication: Journal of Clinical Oncology -- Sept. 15, 2004 North Central Cancer Treatment Group clinical trial View Related
Publication: Journal of Clinical Oncology -- Aug. 15, 2004 North Central Cancer Treatment Group -- intergroup clinical trial View Related
|
LEGAL RESTRICTIONS AND TERMS OF USE APPLICABLE TO THIS SITE
Use of this site signifies your agreement to the terms of use.
© 2012 Mayo Foundation for Medical Education and Research. All rights reserved.
