The TIMP-1 N-terminal strand and EF loop (cyan sticks) bound to MMP-10 (green with semitransparent surface) shows subtle yet significant conformational alterations from the same inhibitor bound to the similar MMP-3 (white sticks) (PDB:1UEA), explaining differences in affinity and offering clues that may aid structure-based design of more selective inhibitors of MMP-3 and MMP-10.
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