Genetics and Model Systems Core

Director: Stephen C. Ekker, Ph.D.

The Genetics and Model Systems Core is a central repository for genetics-based tools and model systems expertise.

Services

Plasmids and other DNA constructs support

• Design
• Construction
• Validation

Expanded zebrafish technical support

Reagents/database

• Transposons
• Bacterial artificial chromosomes
• Custom zinc finger nucleases

Consults and training

• Bioinformatics
  • Microarray design and analysis
  • Next-generation transcriptome and sequence analysis
• Biostatistics consults
  • Key experimental design elements (such as a power analysis for sample size estimates) necessary for designing human genetics studies
• Genetics technologies
  • Rodent and zebrafish transgenic/knockout model development support
  • Viral delivery of siRNA
  • Transposons for somatic genetic engineering
  • In vivo imaging