Mechanisms of carcinogenesis and tumor biology

This group of investigators works to identify and define the molecular mechanisms that support neoplastic transformation of both luminal and solid organs of the gastrointestinal tract. They place special emphasis on:

• Receptor signaling cascades
• Cell death pathways
• Checkpoint control
• Epigenetic transcriptional regulation

• Dihydropyrimidine Dehydrogenase Deficiency - Robert B. Diasio
• Liver Pathobiology - Gregory J. Gores
• Cholangiopathies - Nicholas F. LaRusso
• Cytoskeletal Membrane Dynamics - Mark A. McNiven
• G Protein-coupled Receptors and mRNA Splicing in Cancer - Laurence J. Miller
• Nanomedicine and Materials Science - Priyabrata Mukherjee
• Tumor Angiogenesis and Vascular Biology - Debabrata Mukhopadhyay
• Cell and Molecular Biology of Carcinogenesis - Nicole R. Murray
• Molecular Hepatology - Tushar Patel
• Hepatocellular Carcinoma - Lewis R. Roberts
• Hepatic Vascular Cell Signaling - Vijay H. Shah

• Darren J. Baker, Ph.D.
• Lisa A. Boardman, M.D.
• Navtej (Nav) S. Buttar, M.D.
• Eduardo N. Chini, M.D., Ph.D.
• Peter A. Cohen, M.D.
• Howard C. Crawford, Ph.D.
• Robert B. Diasio, M.D.
• Charles Erlichman, M.D.
• Gregory J. Gores, M.D.
• Baoan Ji, M.D., Ph.D.
• Ningling Kang, Ph.D.
• George P. Kim, M.D.
• Nicholas F. LaRusso, M.D.
• Mark A. McNiven, Ph.D.
• Laurence J. Miller, M.D.
• Priyabrata Mukherjee, Ph.D.
• Debabrata (Dev) Mukhopadhyay, Ph.D.
• Nicole R. Murray, Ph.D.
• Tamas Ordog, M.D.
• Tushar C. Patel, M.B. Ch.B.
• Henry C. Pitot, M.D.
• Lewis R. Roberts, M.B. Ch.B., Ph.D.
• Vijay Shah, M.D.
• Frank A. Sinicrope, M.D.
• Peter Storz, Ph.D.
• Raul A. Urrutia, M.D.

Early detection and prevention

The mission of this group of investigators is twofold:

• Identifying patient subgroups, including people at high risk, which may facilitate the development of novel screening tools and early detection strategies for gastrointestinal cancers.
• Coordinating clinical databases, specimen collection and laboratory activities that support the development of interventions to reduce the incidence and improve the survival of patients at risk of or diagnosed with gastrointestinal cancers.

• Barrett's Esophagus - Kenneth K. Wang
• Gastrointestinal Genetic Epidemiology - Gloria M. Petersen

• David A. Ahlquist, M.D.
• Steven R. Alberts, M.D.
• Borad, Mitesh J., M.D.
• Suresh T. Chari, M.D.
• Michael G. Haddock, M.D.
• Piet C. De Groen, M.D.
• Timothy J. Hobday, M.D.
• Paul J. Limburg, M.D.
• Noralane M. Lindor, M.D.
• Robert R. McWilliams, M.D.
• Heidi Nelson, M.D.
• Gloria M. Petersen, Ph.D.
• Prasad G. Iyer, M.D.
• Kaye M. Reid Lombardo, M.D.
• Daniel J. Sargent, Ph.D.
• Stephen N. Thibodeau, Ph.D.
• Kenneth K. Wang, M.D.