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News, Publications, and Related Stories
Medical Edge Newspaper Dear Mayo Clinic: I've heard there's a new way to treat esophageal cancer that doesn't require removing the esophagus. What does this treatment involve? Does it work as well as the old treatment? View Related 
Medical Edge Newspaper My 32-year-old son visited his doctor because he was having some rectal bleeding. His doctor performed a flexible sigmoidoscopy and discovered a polyp, which she was not able to remove, but recommended he have a colonoscopy soon. She asked about siblings and family history and said his 37-year-old sister should be checked. How common is it for someone to have polyps at this age? View Related 
Medical Edge Newspaper Dear Mayo Clinic: I had a radical nephrectomy of my left kidney six months ago, which showed stage I renal cell carcinoma. My doctor recommends I follow up with a CT scan of the chest and abdomen, along with blood work every six months. Is this aggressive enough? How serious is this disease, and what are the chances it will return or show up elsewhere? View Related
Mayo Clinic Women's HealthSource -- April 7, 2010 Mayo Clinic Women's HealthSource is published monthly to help women enjoy healthier, more productive lives. Revenue from subscriptions is used to support medical research at Mayo Clinic. View Related 
Agent to target gene already being tested at Mayo Clinic in other cancers Researchers at the Mayo Clinic campus in Florida have found that PKC-iota (PKCi), an oncogene important in colon and lung cancers, is over-produced in pancreatic cancer and is linked to poor patient survival. View Related 
The team's findings were presented Oct. 28, 2009, at the annual meeting of the American College of Gastroenterology in San Diego. View Related 
A diagnosis of Barrett's esophagus can be concerning because it increases the risk of developing esophageal cancer. View Related 
Mayo Clinic Study Shows People with Heart Devices Can 'Digest' Advanced Diagnostic Technology Safely
Capsule endoscopy risk appears minimal in largest study to date View Related 
Mayo Clinic Performs Groundbreaking, Single-incision Surgery to Remove Young Woman's Large Intestine
This operation was recommended to the patient because of a diagnosis of familial adenomatous polyposis. Without surgical removal of the colon and rectum, the risk of developing colorectal cancer is 100 percent. View Related 
Publication: Mayo Clinic Proceedings -- Sept. 2009 See video interview with Gordon W. Dewald, Ph.D. View Related 
Medical Edge Newspaper Does having diabetes increase the chance of pancreatic cancer? Would a test at the time diabetes is diagnosed help in the early detection of pancreatic cancer? Does going from diabetes pills to insulin increase the chance of getting pancreatic cancer? View Related 
Offering cancer patients in Florida and the Southeast access to investigational therapies through rigorously monitored clinical trials "The cancer field is rapidly moving to use of these new agents as a way to improve upon the success we have seen with more traditional therapies, such as chemotherapy and radiation," says says Michael Menefee, M.D., who heads the Phase I Clinical Trial Program in Oncology at Mayo Clinic, Jacksonville. View Related 
Medical Edge Newspaper I recently read about a stool test that can detect colon cancer without a colonoscopy. Is it just as effective as a colonoscopy, and if so, when will this be an option for everyone? View Related 
Mayo Clinic Cancer Center receives an additional five years of National Cancer Institute (NCI) funding and re-designation as a comprehensive cancer center. 
Surgery involved removal of entire colon and joining small bowel to rectum A 32-year-old woman from Maricopa, Ariz., who was at risk for colon cancer, is believed to be the first patient in the U.S. to undergo single-incision total colectomy — an operation in which in the entire colon is removed. View Related 
Medical Edge Newspaper -- Read Column My local doctor thinks my reflux is actually Barrett's esophagus. Does this mean I might develop esophagus cancer? View Related 
Multi-center study co-authored by Mayo Clinic reveals promising treatment Dysplastic, or pre-cancerous lesions, can lead to esophageal cancer. Radiofrequency ablation is a procedure that uses high-intensity radio waves to zap the lesions. View Related 
Medical Edge Newspaper -- Read Column I have just been diagnosed with early stage rectal cancer and I'm only 40 years old. Am I going to have to wear a colostomy bag for the rest of my life? What are the statistics for this cancer? View Related
Most people associate colorectal cancer screening with invasive colonoscopy, but previous Mayo Clinic research has shown that stool DNA testing can identify both early-stage colorectal cancer and precancerous polyps. View Related
Pancreatic cancer and bile duct cancer are difficult to diagnose and often fatal because they are discovered in the advanced stages of the disease. View Related 
Study findings presented Saturday, May 30, at the American Society of Clinical Oncology annual meeting in Orlando. View Abstract 
In the May 15 issue of Cancer, Mayo researchers showed that the levels of three proteins (survivin, B7-H1, ki-67) in ccRCC tumor tissue can be used to predict which patients will ultimately die from their cancer. View Abstract 
Presented at the American Society of Clinical Oncology (ASCO) "The benefits were striking in many patients to a degree we have not previously seen in thyroid cancer in response to other therapies, including the standard treatment of radioiodine," says Keith Bible, M.D., Ph.D., a medical oncologist and researcher who led the multicenter clinical trial funded by the National Cancer Institute. View Abstract 
Patient Story -- Wayne Stillman "Mayo's commitment to each patient and to the whole picture, which in my case included genetic testing, saved my life," he says. View Related 
Presented at the American Association for Cancer Research (AACR). The finding is particularly significant, says the study's first author, Mamta Gupta, Ph.D., because the three cell lines studied were all resistant to the effects of chemotherapy - as are many pancreatic tumors - and because the drugs studied are already available for treatment of patients. View Related 
Medical Edge Newspaper So many famous people are in the news with pancreatic cancer these days. Is it a death sentence like the media says? Is it a cancer that can even be detected early? View Related 
Medical Edge Newspaper I am a 73-year-old retired nurse who has a urostomy. As a member of a local ostomy association, I often meet new people who have just had a urostomy or colostomy, and we all agree that it is difficult to find new information. Please share what is important to know about ostomies, especially if there is anything new on the horizon. View Related 
Ablation technique shown effective for patients with high and low-grade dysplasia 
Robotic surgery for the treatment of tonsil and base of tongue cancers is safe, effective and enables faster recovery times. An estimated 24,000 people in the U.S. are diagnosed with throat cancer each year. View Abstract 
"There is need for an agent that has a proven ability to reduce colon cancer risk, and this study suggests that enzastaurin could be uniquely effective," says the study's senior investigator, Nicole Murray, Ph.D., of the Department of Cancer Biology. View Abstract 
Patient Story -- Carolyn Johnson Jay and I both decided that if anything is ever wrong with us, we're going back to Mayo Clinic. View Related 
Publication: Clinical Cancer Research -- Jan. 1, 2009 Mayo Clinic co-auther John Copland, Ph.D. View Related 
William C. Rupp, M.D., has been appointed CEO for the Florida campus effective Nov. 21, Mayo Clinic announced today. Rupp currently leads quality projects for Luther Midelfort, part of Mayo Health System, as well as Mayo Clinic. 
Medical Edge Newspaper Our son recently had his colon removed because of ulcerative colitis. He will soon have the "J-pouch." Can you explain what this involves? Are there new devices or treatments that might prove more effective? View Related
Virtual biopsies will eliminate the need to remove colon polyps that are not cancerous or will not morph into the disease. View Related
"To prevent colorectal cancer deaths, we need an easy-to-use screening tool that consistently finds precancerous polyps," says Dr. Ahlquist. "Stool DNA testing is evolving quickly and may soon fill that need." View Related 
Patient Story -- Danny Snodgrass Laser microsurgery was the right choice for throat cancer patient Danny Snodgrass. View Related 
Study at Mayo Clinic confirms that CT Colonography could serve as screening option "We hope that this additional, less-invasive option for cancer screening will lead more people to get screened and will ultimately result in fewer deaths from colorectal cancer," says C. Daniel Johnson, M.D., principal investigator of the American College of Radiology Imaging Network (ACRIN) National CT Colonography Trial and chair of the Department of Radiology at Mayo Clinic in Arizona. View Related
Mayo Clinic Women's HealthSource -- August 2008 Mayo Clinic Women's HealthSource is published monthly to help women enjoy healthier, more productive lives. Revenue from subscriptions is used to support medical research at Mayo Clinic. View Related 
Patient Story -- James Donnelly Coordinated approach to care brings results for business school professor. View Related
Technique combining chemo-radiation and surgery to be presented at ISIORT conference A study of patients with locally unresectable or borderline resectable pancreas cancer has indicated that the disease survival rates can potentially be doubled by aggressively combining radiation, chemotherapy and surgery. View Related 
Mayo Clinic study reveals longer survival times following staging procedure Pancreatic cancer, even when diagnosed early, often has a poor prognosis. Signs and symptoms may not appear until the cancer is quite advanced and surgical removal is not possible. Pancreatic cancer, as a result, is a leading cause of death. View Related 
A probe so sensitive that it can tell whether or not a cell living within the human body is veering towards cancer development may revolutionize how future colonoscopies are done, say researchers from the Mayo Clinic in Jacksonville, Fla. View Related
This release is being sent in a social media format, in conjunction with the National Cancer Institute, part of the NIH. A new study being presented at the American Society of Clinical Oncology meeting in Chicago (Abstract #4020), may change treatment practice in about 25 percent of patients with colon cancer and is the basis for proposed changes to the way colorectal cancers will be staged. View Related 
Study to be presented at the American Society of Clinical Oncology annual meeting Adding a second monoclonal antibody drug to chemotherapy looks promising for treatment of diffuse large B-cell lymphoma, according to Mayo Clinic researchers working with the North Central Cancer Treatment Group (NCCTG) (http://ncctg.mayo.edu/). View Related 
Findings will enable patients with advanced colon cancer to complete treatment with fewer side effects; study to be presented at the American Society of Clinical Oncology Researchers in the North Central Cancer Treatment Group (NCCTG) have shown that patients who receive intravenous calcium and magnesium before and after the chemotherapy drug oxaliplatin for the treatment of advanced colon cancer experience a significantly reduced incidence and severity of neurological side effects (neurotoxicity). View Related 
Study to be presented at the American Society of Clinical Oncology annual meeting Mayo Clinic researchers and collaborators say they have conclusively demonstrated that a substantial subset of colon cancer patients should not receive chemotherapy because it provides no clinical benefit, and actually may reduce survival time. View Related 
Patient Story -- Bob Grinnell Arizona 'Santa' survives cancer, radiation and gives back to kids — Bob Grinnell's trademark white beard was spared during delicate laser surgery to remove a tumor in his throat. View Related 
Increased expression of SULF2 enhances cancer cell growth and migration, whereas decreased expression reduces both. Deadly and difficult to treat, liver cancer has long resisted attempts by researchers to develop ways to prolong life and prevent recurrence. But Mayo Clinic Cancer Center, in collaboration with the National Cancer Institute, reports in the April issue of Hepatology that the protein sulfatase 2 (SULF2) may provide one of the keys needed to begin the design of new therapies. View Abstract 
Patient Story -- Judi Andress "I'm not crazy," says Judi Andress — probably because her story sounds like it might be. View Related 
What if you could prevent Barrett's esophagus or stop its progression to esophageal cancer? And, while you were working on that, what if you could develop therapies that replace the standard treatment with a much less debilitating treatment than removal of the esophagus? View Related 
Mouse study shows dopamine blocks tumor-feeding blood vessels "Sometimes new drugs may not be the answer. We looked instead at a novel use for an established product and have found very promising results," says Mayo Clinic oncology researcher Sujit Basu, M.D., Ph.D. View Related 
CT colonography, also known as virtual colonoscopy, underwent rigorous studies at Mayo Clinic for more than 10 years, while the stool DNA test was conceived and developed by Mayo Clinic researchers. View Related 
Patient Story -- Doug Yaus Doug Yaus says you have to be involved in your care — and never give up hope — even when your options seem to have come to an end. View Related
Patient Story -- Doug Yaus Doug Yaus says you have to be involved in your care — and never give up hope — even when your options seem to have come to an end. View Related
Agreement strengthens relationship and spawns new scientific collaborations "TGen takes seriously our commitment to work toward helping patients with cancer and other disorders. This announcement is another mechanism allowing TGen and Mayo faculty to work bi-directionally in a more seamless fashion," said Jeffrey Trent, Ph.D., TGen's president and scientific director. View Related
Research into the B7 molecules has been a "family affair" at Mayo. Many Mayo immunologists have joined together to tackle various aspects of their function and behavior and have discovered how they function. 
Patient Story -- David Farrell A tongue tumor threatened to cut short this volunteer firefighter's life, but surgery and radiation put out the cancer's flames. View Related 
Patient Story -- John Simpson John Simpson credits diligent Mayo physicians with catching several different cancers early. View Related 
Study's authors recruit patients for a clinical trail, another step in this ongoing research "We are now quite convinced that in most patients with pancreatic cancer the diabetes is caused by the cancer and not the other way around," says Suresh Chari, M.D., a Mayo Clinic gastroenterologist and the study's lead author. "Our next step is to identify a biomarker for pancreatic cancer-induced diabetes in order to screen patients with new-onset diabetes for early pancreatic cancer and provide surgical treatment as quickly as possible." View Abstract
Removing the entire kidney from younger patients with small kidney tumors may lead to decreased overall survival. "For patients with small kidney tumors, removal of the entire kidney may be associated with long-term consequences that we did not previously recognize when compared to removal of just the tumor," says the study's lead author, R. Houston Thompson, M.D., a Mayo Clinic urologist currently serving a fellowship at Memorial Sloan-Kettering Cancer Center. View Related 
Medical Edge Television Remember the story "Rudolph the Red-nosed Reindeer?" When bad weather almost stopped Santa from delivering gifts on Christmas Eve? Well, the same thing almost happened to the Santa you're about to meet. But instead of dealing with bad weather, this Santa faced an even bigger problem. Throat cancer. And just as the legendary light from that story guided Santa through the storm, a laser light helped this Santa weather the storm of cancer.
Up to 30 percent of patients with colon and rectal cancer may develop a bowel obstruction View Related 
Radiology researchers at Mayo Clinic have invented a diagnostic imaging tool with remarkable capabilities. It's called Magnetic Resonance Elastography or MRE. MRE can measure elasticity - detecting abnormal hardening of liver tissue - sparing some patients the need for a biopsy and allowing physicians to begin intervention aimed at treating their disease before it progresses to cause irreversible damage. View Related 
Publication: Journal of Clinical Oncology -- June 4, 2007 A Final Report of the AIO Colorectal Study Group (Association of Medical Oncology within the German Cancer Society) View Related 
Mayo Clinic Cancer Center had researchers from many disciplines presenting more than 60 oral abstracts and dozens of posters, also educational sessions and other special events throughout the 2007 ASCO program, June 1-5. View Related 
The National Institutes of Health chose Mayo Clinic as one of the first 12 institutions to receive Clinical and Translational Science Awards (CTSA) in October 2006. "There are two objects in medical education: to heal the sick and advance the science." - Dr. Charles H. Mayo 
Yuan-Ping Pang, Ph.D. established the Computer-Aided Molecular Design Laboratory (CAMDL) to learn more about how biological systems function and to establish models that could lead to new treatments for infectious diseases and cancer. View Related 
Clinical Trial Stopped Early Because of Very Positive Results in Treatment Arm A large clinical trial has been halted early because gastrointestinal stromal tumor patients taking Gleevec after surgery did so much better than patients who did not take the drug. The Phase III trial was conducted by the American College of Surgeons Oncology Group (ACOSOG), an NCI Cooperative Group, in collaboration with Cancer and Leukemia Group B, South West Oncology Group, Eastern Cooperative Oncology Group, and National Cancer Institute of Canada Clinical Trials Group. ACOSOG is led by Group Co-chairs Dr David Ota of the Duke Clinical Research Institute, the site of the operations office, and Dr Heidi Nelson of the Mayo Clinic Cancer Center, the site of the Biostatistics. View Related 
Publication: Mayo Clinic Proceedings -- Dec. 2006 Optimism was associated with a higher QOL in survivors of thyroid cancer compared with survivors of head and neck cancer. After adjusting for age, sex, and disease stage, optimism was not associated with QOL for survivors of head and neck cancer. Optimism was more associated with the mental rather than physical QOL subscales.
Doctors at Mayo Clinic have a new weapon in the fight against liver cancer. It's a type of radiation that directly targets the tumor without typical side effects. Medical Edge Television
The Clinical Research Training Program provides a formal education in all aspects of clinical research, including grant-writing, legal and ethical issues, statistics, epidemiology and study design and protocols. "I realized how exciting research can be, and how exciting it is to advance the science." Jon Ebbert, M.D. View Related 
If you have kidney cancer, you might not get symptoms until it's rather advanced. Not long ago a diagnosis like that was bad news. But now, thanks to technology, teamwork and medical expertise, people are beating this deadly disease. Medical Edge Television 
Publication: Cancer -- July 1, 2006 Mononuclear cell infiltration is associated with death from renal cell carcinoma even after multivariate adjustment. Routine documentation of mononuclear cell infiltration is recommended during the pathologic assessment of renal cell carcinoma. View Related 
Medical Edge Television Occasional heartburn is usually nothing to worry about. But if heartburn hits two or more times a week, you may be at risk of developing a condition called Barrett's esophagus that increases your risk of cancer.
In helping young investigators, Mayo Clinic again is connecting all the dots -- leading back to the same point, the same mission, ongoing and yet unchanged for over a century: the needs of the patient come first. New, young investigators are critical to biomedical research. Their fresh ideas, innovativeness, and enthusiasm are necessary for scientific progress. Yet the steps from a junior research position toward a self-sufficient laboratory can be difficult. Mayo Clinic is dedicated to fostering future, investigators. Here we look at two of them and what Mayo is doing to help. View Related
The invention of a novel imaging biotechnology called vibro-acoustography was reported in 1998, a fruit that matured from a mind dedicated to a deeper understanding of the mathematical and physical concepts that produce clear images of internal anatomy. James Greenleaf, Ph.D., a Mayo Clinic scientist and director of the Ultrasound Research Laboratory, is praised by the scientific community as one of the most creative scientists in ultrasonic biomedical imaging science. This article explores his contributions—novel ultrasound treatments, and biotechnology that produces clear images, some in 3D, of tiny structures deep within the body. View Related
Renal cell carcinoma is one of most dangerous forms of kidney cancer. An interdisciplinary team of Mayo Clinic investigators and Mayo's Comprehensive Cancer Center are pursuing improved treatments by pooling data and expertise with support from Florida. "With this approach, we can halt the disease and begin to cure kidney cancer." John Copland, M.D. View Related 
Publication: Journal of Clinical Oncology -- Dec. 20, 2005 A North Central Cancer Treatment Group Phase II study View Related 
Publication: Journal of Clinical Oncology -- Dec. 1, 2005 Individual patient data from 20,898 patients on 18 randomized trials: North Central Cancer Treatment Group View Related
Gemcitabine and ISIS-2503 for patients with locally advanced or metastatic pancreatic adenocarcinoma
Publication: Journal of Clinical Oncology -- Dec. 15, 2004 North Central Cancer Treatment Group clinical trial View Related
Publication: Journal of Clinical Oncology -- Aug. 15, 2004 North Central Cancer Treatment Group -- intergroup clinical trial View Related 
Publication: Journal of Clinical Oncology -- June 15, 2004 North Central Cancer Treatment Group with National Cancer Institute of Canada View Related 
Publication: Journal of Clinical Oncology -- May 15, 2004 North Central Cancer Treatment Group pooled results with US Gastrointestinal Intergroup and the National Surgical Adjuvant Breast and Bowel Project View Related
Publication: Journal of Clinical Oncology -- May 1, 2004 North Central Cancer Treatment Group study View Related
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