Liver Pathobiology - Gregory J. Gores

Overview

The Liver Pathobiology Laboratory is focused on the cellular and molecular mechanisms by which dysregulation of cellular apoptosis results in disease pathogenesis. The laboratory focuses on the fundamental mechanisms resulting in liver cell apoptosis. In particular, signaling cascades involving death receptors, mitochondrial dysfunction, and lysosomal permeabilization are intense subjects of investigation. Indeed, we have been pioneers in the role of lysosomal permeabilization in mediating cellular apoptosis. We have also provided mechanistic insight into how lipoapoptosis occurs in liver cells. In addition to elucidating processes fundamental in cell biology, the laboratory also explores mechanisms by which apoptosis modulates whole organ function. The role of apoptosis in mediating liver injury and in particular, fibrosis, remain ongoing research efforts.

The mechanisms by which chronic inflammation result in dysregulation of apoptosis promoting carcinogenesis of the biliary tree is also an area of ongoing study. Currently we are interested in the cellular processes by which inflammatory cytokines help cells evade apoptosis permitting the accumulation of mutations, thereby fostering malignant transformation. Ongoing efforts are focused on mechanisms to restore apoptosis sensitivity in these cells to aid in therapeutic strategies and endeavors.

The laboratory is currently supported by three NIH Grants. The laboratory encompasses approximately 1,400 square feet of space and is extremely well equipped. The laboratory has expertise in confocal microscopy, real-time PCR, cell-free systems, and proteins interactions. Individuals interested in pursuing research in the liver pathobiology laboratory are encouraged to contact Dr. Gores directly.