Memory Disorders - Neill R. Graff-Radford

The laboratory of Neill R. Graff-Radford, M.D., is actively engaged in clinical and translational research and is part of the:

• Clinical core of the Alzheimer's Disease Research Center (ADRC) at Mayo Clinic
• Memory Disorders Clinic at Mayo Clinic in Florida, one of 15 such clinics designated by the state of Florida through its Alzheimer's Disease Initiative
• Alzheimer's Disease Cooperative Study, a National Institute on Aging-funded consortium that carries out clinical trials in Alzheimer's disease
• Alzheimer's Disease Neuroimaging Initiative, a national group funded by the National Institutes of Health and industry

As part of its ADRC activities, the lab is involved in a number of studies related to cognitive impairment in African-Americans. Additionally, the lab is characterizing patients and controls in a large genetic initiative that aims to discover genes related to late-onset Alzheimer's disease, as well as investigating normal pressure hydrocephalus and evaluating if amyloid-beta (Aβ) brain imaging can be used to predict if surgery will help.

Dr. Graff-Radford's laboratory works collaboratively with:

• The laboratory of Rosa Rademakers, Ph.D., to find genes related to frontotemporal dementia
• Tanis J. Ferman, Ph.D., and Dennis W. Dickson, M.D., on the clinical features and neuropathology of Lewy body dementia
• The laboratory of Steven G. Younkin, M.D., Ph.D., in studying a blood test to predict some of the risk of Alzheimer's disease