Our group engages in advanced research in regenerative neuroscience from the molecular to cell biological and integrative levels. A key research goal is to understand the mechanisms underlying the guidance of nerve growth in the developing and regenerating nervous system. Within this theme, specific topics under investigation include molecular analysis of receptors and signal transduction mechanisms; axon guidance, target recognition and regeneration; formation and plasticity of synapses; and development of neural networks. Related topics we are investigating are the regulation of glioma cell motility and mechanisms controlling vascular development and regeneration. The lab offers an integrated approach to training in modern neurobiology, utilizing molecular, biochemical and cell biological techniques as well as advanced optical imaging. Members of the lab have the opportunity to work closely with the Spinal Cord Injury research team at Mayo.
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