Lung Deformation Injury - Rolf D. Hubmayr

Overview

Research in my laboratory focuses on both mechanisms and biologic sequalae of lung deformation. There is overwhelming experimental evidence that large lung deformations promote edema and may trigger inflammation. This evidence has generated an intense debate about the appropriate choice of ventilator settings for patients with injured lungs and has fueled research on the mechanisms of ventilator-induced lung injury (VILI). We are addressing this problem using different experimental models that range in scale from whole animals to structural elements of individual cells.