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Researchers say the findings from Mayo Clinic's campuses in Florida and Minnesota suggest that patients and their physicians should not overly worry about toxicity and side effects from the treatment, known as salvage external beam radiotherapy.

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Patient Story -- Harold Willhite
"Nothing's in a rush," says Harold, back in his workshop after surviving two lung cancers.
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NCI Cancer Bulletin: July 28, 2009 • Volume 6 / Number 15

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The Daily Journal, International Falls, Minn. -- July 7, 2009

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National Cancer Institute Icon

Mayo Clinic Cancer Center receives an additional five years of National Cancer Institute (NCI) funding and re-designation as a comprehensive cancer center.

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Presentation at the annual meeting of the American Urological Association

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Arizona News: Mayo Clinic to do one-day 'virtual' colonoscopy and complete colonoscopy if needed.
Regular screening is the most powerful weapon available for preventing colon cancer.
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Publication: New England Journal of Medicine -- Dec. 25, 2008

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William C. Rupp, M.D., has been appointed CEO for the Florida campus effective Nov. 21, Mayo Clinic announced today. Rupp currently leads quality projects for Luther Midelfort, part of Mayo Health System, as well as Mayo Clinic.


virtual biopsies will eliminate the need to remove colon polyps that are not cancerous or will not morph into the disease.

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Study at Mayo Clinic confirms that CT Colonography could serve as screening option
"We hope that this additional, less-invasive option for cancer screening will lead more people to get screened and will ultimately result in fewer deaths from colorectal cancer," says C. Daniel Johnson, M.D., principal investigator of the American College of Radiology Imaging Network (ACRIN) National CT Colonography Trial and chair of the Department of Radiology at Mayo Clinic in Arizona.

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Mayo Clinic Arizona receives second high-definition CT scanner in world
News from Arizona
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Patient Story -- Deborah Evens and Gayla Holmgren
Vitamin B12 imaging gives breast cancer survivors another option.
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Technique combining chemo-radiation and surgery to be presented at ISIORT conference
A study of patients with locally unresectable or borderline resectable pancreas cancer has indicated that the disease survival rates can potentially be doubled by aggressively combining radiation, chemotherapy and surgery.

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Medical Edge Newspaper
Dear Mayo Clinic:
I've been reading that people shouldn't get CT scans unless they're necessary. How do I know if it's necessary? And how real are the risks of cancer from a CT scan?

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colon tumor

CT colonography, also known as virtual colonoscopy, underwent rigorous studies at Mayo Clinic for more than 10 years, while the stool DNA test was conceived and developed by Mayo Clinic researchers.

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Agreement strengthens relationship and spawns new scientific collaborations
"TGen takes seriously our commitment to work toward helping patients with cancer and other disorders. This announcement is another mechanism allowing TGen and Mayo faculty to work bi-directionally in a more seamless fashion," said Jeffrey Trent, Ph.D., TGen's president and scientific director.
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Using two different endoscopes together is better than using one to stage lung cancer, and is also much more precise and less invasive than the surgical method now most commonly used.
"Both scopes together found more malignant lymph nodes than did the use of a single endoscope," says the study's lead investigator, Michael Wallace, M.D., M.P.H., Professor of Medicine at Mayo Clinic, Jacksonville, Fla. "Doing both procedures at once takes little time, requires only a mild sedative, and patients go home the same day."
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Mayo logo

News from Rochester, Minn.
Stereotactic radiosurgery uses precisely focused radiation to treat tumors and other abnormal growths in the brain.
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Collaboration aims to find high-tech solutions for quicker diagnosis, better treatments
"This facility will allow us to explore projects in medical imaging and radiology that can provide faster and better information for our physicians, and in turn, improved treatments for our patients," said Bradley Erickson, M.D., Ph.D., head of Mayo's Radiology Informatics Lab.
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News from Jacksonville, Fla.
Several programs exist nationally to provide free breast cancer screening mammograms to underserved women, but there is no unified system for providing diagnostic services when abnormalities on the mammograms are detected.

Mayo Clinic has been working on some options.
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kidney

Presented at the 2007 meeting of the Radiological Society of North America in Chicago
Also called cryotherapy or cryosurgery, cryoablation is a procedure in which extreme cold is applied to the tumor using a cryoprobe, a hollow needle-like device filled with argon gas. The gas rapidly freezes the targeted tumor.


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bone cancer

Presented at the 2007 meeting of the Radiological Society of North America
"Cancer patients are living longer and we need to be able to manage their pain over a long period of time," says Matthew Callstrom, M.D., Ph.D., a radiologist at Mayo Clinic
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breast cancer image

Presented at the annual meeting of the American Society for Therapeutic Radiation and Oncology (ASTRO)
"This tells us that the standard course of therapy isn't that bad in terms of its exposure to normal tissue, but also that, sometimes, partial breast irradiation may not spare as much normal tissue as we hope," says the study's lead investigator, Laura Vallow, M.D.

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Presented at the annual meeting of the American Society for Therapeutic Radiation and Oncology (ASTRO)
"Most of these patients don't have other effective treatment options, because surgery is not possible if there are multiple tumors in their liver," says the study's lead investigator, Laura Vallow, M.D. "But with this radiotherapy, no new tumors developed in patients who responded and we find this to be very encouraging."
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Mayo Clinic Proceedings

Publication: Mayo Clinic Proceedings -- Oct. 2007

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brain

Jacksonville, Fla.
This technology, an intraoperative Magnetic Resonance Imaging (MRI) system known as the IMRIS Neuro system, allows surgeons to use real-time imaging as they operate and uses a unique ceiling-mounted track that moves the MRI system to the patient rather than the patient having to be moved to the magnet.
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MRE image of liver with fibrosis

Radiology researchers at Mayo Clinic have invented a diagnostic imaging tool with remarkable capabilities. It's called Magnetic Resonance Elastography or MRE.
MRE can measure elasticity - detecting abnormal hardening of liver tissue - sparing some patients the need for a biopsy and allowing physicians to begin intervention aimed at treating their disease before it progresses to cause irreversible damage.
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ASCO<br />

Mayo Clinic Cancer Center had researchers from many disciplines presenting more than 60 oral abstracts and dozens of posters, also educational sessions and other special events throughout the 2007 ASCO program, June 1-5.

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The National Institutes of Health chose Mayo Clinic as one of the first 12 institutions to receive Clinical and Translational Science Awards (CTSA) in October 2006.
"There are two objects in medical education: to heal the sick and advance the science." - Dr. Charles H. Mayo
bone scan

Osteoporosis was not even considered a disease before Mayo Clinic's 1980s groundbreaking epidemiology studies.
Funded by a $1.2 million per year NIH Program Project grant, the osteoporosis research team is also taking their research to the genetic and molecular levels to study the physiology of bone metabolism in an aging population. Their studies investigate the TGF-beta-Inducible Early Gene (TIEG) gene's role in bone and skeletal disorders such as osteoporosis and breast cancer metastasis to the bone.
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Prognostic enzyme for nasopharyngeal cancer identified
"We continue to look for ways to combat health disparities in the United States and throughout the world," said Lewis Roberts, M.B.Ch.B., Ph.D., the study's principal investigator and a gastroenterologist at Mayo Clinic. "Our research into SULF2 suggests a number of promising possibilities for the development of more effective treatments for cancer."

Imaging application produces results up to fifty times faster than on typical processors
"This alignment of images both improves the accuracy of interpretation and improves radiologist efficiency, particularly for diseases like cancer," says Bradley Erickson, M.D., Ph.D., Mayo Clinic radiology researcher.


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NCCTG

Publication: Journal of Clinical Oncology -- Apr. 1, 2007
Results of a Prospective Phase III North Central Cancer Treatment Group Clinical Trial
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kidney cancer

Early findings showing short-term success in more than 90 percent of selected patients are published in the March 2007 issue of Radiology.
"This procedure appears to be a good option for some patients," says Thomas Atwell, M.D., Mayo Clinic radiologist and the study's primary investigator. "It makes their hospital stay and recovery time very short and surgical stress is minimal."
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mammogram

A redesign of the primary care practice to enable appointment secretaries to schedule preventive services was a key to the program's success.
"Not everyone needs to see a doctor every year, but they still should get the appropriate preventive care and screenings," explains Robert Stroebel, M.D., chair, Division of Primary Care Internal Medicine at Mayo Clinic and the study's senior author. "We were pleasantly surprised at how much we could increase mammography percentages through this new system."
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Mayo Clinic Proceedings

Publication: Mayo Clinic Proceedings -- March 2007
Mammography added little information to the initial patient evaluation. Breast cancer may be suspected by the presence of a dominant mass. Gynecomastia can be predicted on the basis of the patient's symptoms or preexisting condition. Patients with suspicious findings on examination warrant appropriate clinical management regardless of mammographic findings. Mammography in men may be of benefit only for image guidance of percutaneous biopsy of a suspicious mass.

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lung cancer

Death Rates for Smokers Remain the Same Despite Early Diagnosis
An international study looking at computed tomography (CT) to screen current or former smokers for lung cancer found that the screening did not reduce death. Researchers from Mayo Clinic Cancer Center, along with the Instituto Tumori, Milan, Italy; and Memorial Sloan-Kettering and Moffitt Cancer Centers collaborated to report the findings, which are published in the Mar. 7, 2007, issue of the Journal of the American Medical Association (JAMA).
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mri

"This new technology allows a multidisciplinary approach to be performed safely in these rare tumors that were once considered unresectable."

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lunb biopsy

Medical Edge Newspaper Column
DEAR MAYO CLINIC:
Which is better for detecting lung cancer -- X-ray or CT scan? Are too many X-rays or scans detrimental to your health? If you're at high risk for lung cancer, how often should you get a scan? -- Bainbridge Island, Wash.
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Many men have breast symptoms, including enlarged or painful breast tissue, but the majority do not need a mammogram, say researchers from Mayo Clinic Cancer Center.
"In the vast majority of cases, a mammogram is not necessary for confirming a diagnosis of gynecomastia. Breast cancer is rare and most often easily detected on physical examination," says Dr. Hines. "The bottom line is that most men don't need a mammogram, and that is good news for them."
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A New Gamma Camera Technique for the Detection of Small Breast Tumors
A diagnostic device that resembles a mammography unit can detect breast tumors as tiny as one-fifth of an inch in diameter, which may make it a valuable complementary imaging technique to mammography, say researchers at Mayo Clinic, who helped develop the technology along with industry collaborators Gamma Medica and GE Healthcare.

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Physicians at Mayo Clinic are now using tiny glass bubbles filled with radioactive material to deliver high doses of tumor-killing radiation directly to liver tumors.
"The technique is a clever way of exploiting the differences in blood supply between the liver tumor and normal liver tissue," says Mayo Clinic interventional radiologist Ricardo Paz-Fumagalli, M.D. He, along with Mayo Clinic radiation oncologists, deliver the therapy to patients.


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Mayo Clinic's ability to find and diagnose breast cancer has increased with the addition of two new digital mammography machines, the most cutting-edge screening and detection technology available for some women.
An advance in the field of screening and diagnosing breast cancer, digital mammograms are proving to have their niche. "A large trial published in 2005 found digital mammograms have increased accuracy in three categories of patients," says Elizabeth DePeri, M.D., a radiologist in Mayo's Breast Clinic.
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NCCTG

Publication: Journal of Clinical Oncology -- Dec. 1, 2006
North Central Cancer Treatment Group
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prostate

Mayo Clinic Cancer Center's Specialized Programs of Research Excellence (SPORE) grant from the National Cancer Institute (NCI) for prostate cancer research has been renewed for an additional five years.
SPORE grants are highly competitive awards given to institutions on the cutting edge of translational research in specific types of cancer.

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mid-torso MRI

The Magnetic Resonance (MR) lab at Mayo Clinic has invented new MR technologies that have been incorporated into every MR scanner in the world.
Their inventions help millions of people. And MR investigators work closely with their clinical colleagues to bring state-of-the-art biotechnology to patient care in record time. It's a dynamic lab that has earned an international reputation for continually finding novel ways to use imaging. This article describes some of those novel technologies, the MR lab's past achievements, current projects and an enticing look into what we can expect from this dynamic lab in the future.
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prostate

Publication: New England Journal of Medicine -- Oct. 12, 2006

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butterfly quilt

This annual education event brings cutting-edge research and the clinicians and scientists who study it to those who are interested in women's cancers.

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Mayo Awarded $72 Million for Clinical and Translational Research
"The Mayo Clinic Center for Clinical and Translational Research will coordinate the efforts of our outstanding clinical research education and training programs, our world-class scientists and clinical research investigators, and the vast resources of Mayo Clinic to speed the process of turning our research discoveries into the medications and treatments our patients need and expect," says Robert Rizza, M.D., Mayo Clinic's director for research and the director of the new center.
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Dr. Jon Ebbert

The Clinical Research Training Program provides a formal education in all aspects of clinical research, including grant-writing, legal and ethical issues, statistics, epidemiology and study design and protocols.
"I realized how exciting research can be, and how exciting it is to advance the science."

Jon Ebbert, M.D.

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Pill camera a breakthrough in non-invasive diagnosis of digestive disorders
Called video capsule endoscopy, Mayo Clinic in Arizona was one of only three centers in the U.S. to begin doing the procedure in 2001, very shortly after it was approved by the FDA.
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mammography patient

Medical Edge Television
Doctors at Mayo Clinic did a study to find out if giving women information before they have a mammogram makes a difference in their experience.
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Native Circle

"This collaboration will enable us to work with the Indian Health Service to address health care-related needs specific to Native Americans, ranging from developing research initiatives to address unique problems, to finding ways to improve access to medi

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esophagus, photodynamic therapy

Medical Edge Television
Occasional heartburn is usually nothing to worry about. But if heartburn hits two or more times a week, you may be at risk of developing a condition called Barrett's esophagus that increases your risk of cancer.
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In helping young investigators, Mayo Clinic again is connecting all the dots -- leading back to the same point, the same mission, ongoing and yet unchanged for over a century: the needs of the patient come first.
New, young investigators are critical to biomedical research. Their fresh ideas, innovativeness, and enthusiasm are necessary for scientific progress. Yet the steps from a junior research position toward a self-sufficient laboratory can be difficult. Mayo Clinic is dedicated to fostering future, investigators. Here we look at two of them and what Mayo is doing to help.
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Mayo Clinic Proceedings

Publication: Mayo Clinic Proceedings -- June 2006
The results suggest that providing women scheduled for screening mammograms with physician-approved educational material before their appointment significantly increases knowledge about screening mammography, risks and benefits, and possible follow-up.

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Dr. Diasio

Robert B. Diasio, M.D., has been appointed Mayo Clinic Cancer Center Director, succeeding Franklyn Prendergast, M.D., Ph.D.
Dr. Diasio, who will be based at Mayo Clinic in Rochester, will also direct cancer center activities at Mayo Clinic in Arizona and Mayo Clinic in Jacksonville, Fla.
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lymphoma

While the incidence of most cancers has been declining, that of non-Hodgkin's lymphoma has been on the rise. It is the fifth most common type of cancer diagnosed in the United States, with an estimated 300,000 Americans currently living with the disease.
Radio-Immunotherapy Holds Promise for Patients with Lymphoma
"I'm sorry, Mrs. Wolter, but your cancer is back." Charlotte Wolter had heard this before. The Glencoe, Minn., resident had endured seven months of chemotherapy. And now, after participating in a clinical trial she had hoped would put her cancer into remission, she was hearing the words again.
For Wolter and many other patients battling B-cell non-Hodgkin's lymphoma, chemotherapy and radiation often result in tumors shrinking but recurring in the same or other locations. At the same time, there is no cure for the disease. These patients brave difficult treatment regimens, endure a host of side effects, yet still fail to hear those magic words: you're cancer-free.
But now a new drug, known as Zevalin, is giving hope to patients who no longer respond to other treatment options. For patients like Wolter, Zevalin appears to be a wish come true.
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The first radiation therapy and respiratory care baccalaureate classes of Mayo School of Health Sciences and the University of Minnesota will be conferred on Friday, May 12, 2006, at Mayo Clinic.

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vibro acoustic

The invention of a novel imaging biotechnology called vibro-acoustography was reported in 1998, a fruit that matured from a mind dedicated to a deeper understanding of the mathematical and physical concepts that produce clear images of internal anatomy.
James Greenleaf, Ph.D., a Mayo Clinic scientist and director of the Ultrasound Research Laboratory, is praised by the scientific community as one of the most creative scientists in ultrasonic biomedical imaging science. This article explores his contributions—novel ultrasound treatments, and biotechnology that produces clear images, some in 3D, of tiny structures deep within the body.

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Opus Center

Mayo Clinic broke ground this morning for a new building to house advanced imaging research. Mayo received a gift of $7 million from The Opus Group to support construction of the facility.
"Much of medicine in the future will depend heavily on noninvasive imaging techniques," says Denis Cortese, M.D., CEO of Mayo Clinic. "We are grateful for this generous gift from Opus, which will help us expand both our diagnostic and treatment capabilities through the findings of this research. Applying basic science research findings to patient care is what we do best, and we look for this activity to keep Mayo Clinic on the cutting edge of imaging."
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In terms of a medical diagnosis, nothing is more devastating than hearing the "C" word - cancer. But now, ASU and Mayo Clinic are hoping that five different C's will become the best arsenal against the big C.
The organizations have teamed up to introduce a new research entity called MAC5.

MAC5 is short for the Mayo Clinic - ASU Center for Cancer-related Convergence, Cooperation and Collaboration.

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Publication: Mayo Clinic Proceedings -- Dec. 2003

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