We are seeking a highly motivated postdoctoral fellow to study cell cycle control and genome instability in cancer. We are particularly interested in ubiquitin-mediated pathways (Genes & Dev. 21, 184-194; Mol. Cell 23, 589-596) and current projects include studying deubiquitinase involved in cell proliferation....

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Funded through an R01 grant, a postdoctoral research position is currently available in heart bioenergetics and metabolic signaling at Mayo Clinic. The NIH-sponsored project is focused on AMP signaling, molecular mechanisms of interaction and function of the adenylate kinase/AMPK signaling circuit and cardioprotection. Applications are invited from PhD graduates in biological sciences with strong experience in mouse heart physiology, energetics/ion homeostasis, protein-protein interaction, ische...

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A postdoctoral position as a Research Associate is currently available in the Division of Biomedical Informatics. The candidate will work closely with senior investigators on research activities relating to clinical natural language processing (clinical NLP). Research activities and successful findings will be translated into development activities for existing division projects and extramurally funded research programs. The preferred candidate will be aided by experience in research or dev...

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Two postdoctoral positions are available at Mayo Clinic Rochester. The successful candidate(s) will join the Bioinformatics Core to complement the current expertise of the team with Computational Chemistry. The core plans to expand its research activity in the area of analysis of metabolomics data and development of computer model(s) for the prediction of chemical reactivity. This last project is done in collaboration with the IBM Blue Gene team. The successful candidate(s) will have a stron...

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A postdoctoral position is available immediately as part of a project that integrates X-ray crystallography and biochemistry to study protein complexes involved in cell cycle checkpoint signaling and DNA repair. The ideal candidate should have a recent doctoral degree with demonstrated experience in macromolecular crystallography and protein biochemistry. Applicants should be highly motivated. http://mayoresearch.mayo.edu/mayo/research/staff/mer_g.cfm...

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The applicant should be a postdoctoral fellow with basic animal and laboratory skills. He/She should be able to perform PCR for genotyping, immunohisto/cytochemistry, protein analysis, Western and Northern analysis. ...

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A postdoctoral position is available in a dynamic and enthusiastic environment in the Department of Ophthalmology, Mayo Clinic, Rochester, MN. The research focus of the laboratory is in understanding the cell and molecular aspects of glaucoma. Glaucoma is an eye disease that affects 70 million people worldwide. One of the main risk factors for glaucoma is high intraocular pressure. The tissue involved in the maintenance of intraocular pressure is the trabecular meshwork, a filter-like tissue mad...

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We are seeking a post doctoral person with good chemistry skills to work on serum biomarker method development and validation for Prostate Cancer. The project involves chromatographic fractionation of blood using various extraction systems and/or affinity columns. Quantitation of trypsin digested fragments is by API 5000 tandem mass-spectrometry(MS/MS)....

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A Postdoctoral Fellow/Research Associate position is avaiable in cardiovascular ion channel physiology. The focus of our research is on the regulation of ion channels in heart and blood vessels in diabetes. We perform whole-cell and single channel recordings in isolated cardiac and vascular myocytes and in cultured cells expressing wild-type and mutant channels. We also create transgenic models to study the molecular mechanisms through which reactive oxygen species modulate ion channels in diabe...

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A postdoctoral position is available after August 1, 2008 as part of an NIH-funded project to build upon our initial genetic screens to identify novel regulators of T cell development and activation. As proof-of-principle using this approach, we have recently cloned a novel transcriptional repressor that is absolutely required for the development of several hematopoietic lineages. Our research crosses many disciplines: Immunology, Biochemistry, Molecular Biology, Cancer and Development. The i...

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A postdoctoral position is available after August 1, 2008 as part of an NIH-funded project that examines the function of a novel transcriptional repressor in hematopoiesis and leukemogenesis, using conditional knockout mice. Our research crossses many disciplines: Immunolgy, Biochemistry, Molecular Biology, Cancer and Development. The ideal candidate should have a recent doctoral degree in any of those field, as demonstrated by 1-2 first author papers publications resulting from their dissert...

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Postdoctoral position available immediately to study the pathophysiology of kidney and vascular diseases. Dr Nath's laboratory has special interests in the study of acute renal failure, heme oxygenase, vascular access dysfunction, and sickle cell disease, employing rodent disease models and a broad range of analysis techniques. Applicant should have experience with animal experimentation and preferably have some experience with biochemical and molecular analysis techniques. Candidate should also...

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NIH-funded postdoctoral Training Grant in Allergic Diseases is available to prepare qualified individuals for careers as investigators of allergic diseases and asthma. Only US citizens or permanent residents (green card holder) with Ph.D., M.D., or M.D.-Ph.D. (or equivalent) degrees are eligible to apply. Ongoing studies in the Allergic Diseases Research Laboratory include: 1) eosinophil biology and the roles of eosinophils in health and disease, 2) Th2 innate immunity and Th2 development, and 3...

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A postdoctoral position is available in the laboratory of Dr. Storz to study protein kinase D (PKD) function in human cancer using both, cell-based and animal models at the Mayo Clinic Comprehensive Cancer Center in Jacksonville, Florida. The project will comprise analysis of cell signaling and gene induction in tumor cells and tumor biology in mice. Experience in common molecular biological, cell biological and biochemical methods is required. Background in confocal microscopy, tumor biology an...

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POSTDOCTORAL FELLOWSHIPS Gene Therapy in the Eye Department of Molecular Medicine, Mayo Clinic. Postdoctoral scientists will work with lentiviral vectors encoding novel therapeutic transgene systems to treat eye diseases such as glaucoma. Applicants are sought with expertise and ambition in at least one of two areas: (1) experimentation in the eye; (2) gene therapy vectorology/virology, or molecular biology skills applicable to the latter....

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POST-DOCTORAL FELLOWSHIPS Molecular and Cellular Biology of HIV-1 (Molecular Virology, Bioinformatics, Proteomics) Department of Molecular Medicine, Mayo Clinic. Post-doctoral scientists will investigate cellular proteins with critical roles in HIV-1 biology, e.g., the replication cofactor & integration targeting roles of LEDGF/p75. Applicants are sought with expertise and ambition in at least one of three areas: (1) virology/vectorology, or molecular biology skills applicable to the latt...

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Newly funded R01 grant ("Radiovirotherapy for Multiple Myeloma" requires a motivated postdoctoral scientist interested in joining the group of Stephen Russell to develop clinically viable approaches that will enhance the therapeutic index of radiovirotherapy in patients with multiple myeloma. Experience in molecular virology, immunology, and/or radiosotopic imaging studies highly advantageous....

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Newly funded R01 grant ("Antibody Neutralization of Therapeutic Viruses") requires a motivated postdoctoral scientist interested in joining the group of Stephen Russell to develop viable strategies to increase the efficiency of measles delivery to disseminated myeloma sites in measles-immune subjects. Experience in virology and/or immunology highly advantageous....

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A postdoctoral position in molecular biology is available to investigate mechanisms of resistance to chemotherapy in ovarian cancer. Motivated candidates should have a Ph.D. or M.D./Ph.D. in cancer biology, cell biology, or reproductive biology with a strong background in molecular biology techniques, mouse models, and/or experimental therapeutics. Prior research experience with gene expression analysis, DNA isolation, PCR-based technique, molecular cloning, clonogenic assays, and mouse work i...

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A postdoctoral fellow position is available to study the molecular mechanism of aging and cancer. We are interested in the DNA damage response pathway, which is important for maintaining genomic stability and tumor suppression (Nature 421:957-961, 2003; Nature Structure and Molecular Biology, 12:589-563, 2005; Molecular Cell, 21:201-14. 2006). In addition, we are interested in the regulation of protein deaetylase SirT1 and its implication in aging and cancer (Nature, 451: 583-6, 2008). ...

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A postdoctoral research fellow is sought in the oncology research laboratory of an established clinician investigator beginning in summer 2008. Ongoing studies in the laboratory include 1) small molecule anticancer agent mechanism of action studies with emphasis on ROS and redox pathways, transcription factors, and other signaling pathways; 2) identification of novel therapies for multiple myeloma, ovarian cancer, thyroid cancer and other malignancies; and 3) translational studies involving pat...

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A postdoctoral research position is available to study the cell biology of bone cells. The laboratory is part of a highly collaborative group that includes laboratories in the departments of Endocrinology, Biochemistry and Molecular Biology, and Orthopedic Surgery at the Mayo Clinic. Projects focus on mechanisms of osteoclast differentiation and survival, interactions between osteoclasts and osteoblasts, and commitment of osteoprogenitor stem cells. A background in cell biology or biochemistry a...

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A postdoctoral position is available immediately as part of a project that integrates X-ray crystallography and biochemistry to study protein complexes involved in DNA repair and cell cycle checkpoint signaling. The ideal candidate should have a recent doctoral degree with demonstrated experience in macromolecular crystallography and protein biochemistry. Applicants should be highly motivated. http://mayoresearch.mayo.edu/mayo/research/staff/mer_g.cfm...

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Postdoctoral Scientist A postdoctoral scientist position is available for a Ph.D. scientist in the field of Developmental Biology, Cell Biology, and Molecular Genetics to study RAS signal transduction in Drosophila melanogaster, mouse models and human cancer cells. A strong background and considerable experience in molecular genetics, molecular biology and biochemistry are absolutely required for this position. Highly motivated, creative, talented and energetic candidates with extensive genet...

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Postdoctoral Fellowships to study Neurodegenerative disease. The Neuroscience Department at Mayo Clinic Jacksonville http://mayoresearch.mayo.edu/mayo/research/mcj_neuroscience.cfm) is internationally recognized for excellence in basic and translational research on Neurodegenerative disease, especially Alzheimer's and Parkinson's disease. Our unique departmental focus, collaborative nature, and interaction with our clinical colleagues provide an excellent postdoctoral training environment. Postd...

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Looking for a highly motivated experienced individual to work on applying the power of Next Generation DNA sequencing technology towards two key projects. (1) Identifying rare mutations from complex mixtures; and (2) Developing genomic profiles of large numbers of cancer specimens. Molecular biolgy experience, plus familiarity with this new and powerful technology. Possibility of a more senior level position for a more experienced individual....

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Postdoctoral Position; Research Fellow or Associate based on experience; Academic appointment based on experience. Ph.D. level scientists at the post-doctoral or research associate level are sought to participate in research on complex traits affecting the eye with an emphasis on age-related macular degeneration (AMD). Expertise in either (i) molecular genetics of complex traits or (ii) pathogenesis of disease using biochemical and animal studies of the eye is desired. Applicants would join...

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NIH-funded postdoctoral position is available immediately to study genetic basis of atherosclerotic vascular disease and intermediate phenotypes (include circulating levels of lipids and novel risk markers), using linkage and association methods. The candidate should be familiar with conventional linkage and association analyses using various genetics software packages as well as the analyses of genome-wide association studies of cardiovascular phenotypes. The (MD or PhD) candidate should be...

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I invite you to apply for one of two postdoctoral positions, which are available immediately. The projects of interest to the laboratory are relevant to (1) the molecular mechanism for genetic instability and CAG expansion, the mutations underlying Huntington's Disease, (2) protein purification and biochemistry of DNA repair enzymes, (3) the pathogenesis and cell biology of Huntington's Disease, and (4) drug discovery. The projects involve a range of techniques including gel electrophoresis, PCR...

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One position is open in my lab. We use Caenorhabditis elegans as a model to focus on understanding the molecular mechanisms of cilia biogenesis, cilia function, and human cilia-related diseases. A multidisciplinary approach that integrates genetics, molecular biology, biochemistry, behavior, and microscopy is used to address our research objectives. The postdoctoral fellow(s) will join several ongoing efforts to define polycystin functions, ciliary localization, and cilia biogenesis. A Ph.D. in ...

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Motivated postdoctoral scientists are invited to join the group of Jann Sarkaria to develop novel therapeutic strategies for the treatment of brain tumors. Current projects in the laboratory are focused on understanding the basis of resistance to chemotherapy and radiation, identifying methods to overcome therapy resistance, and integration of novel signal transduction and DNA repair inhibitors into chemo-radiotherapy for treatment of glioblastoma multiforme. Numerous in vitro and in vivo tumor ...

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Highly motivated individual will work with Next Generation DNA sequencing and develop technologies for the enrichment of specific DNA sequences from highly complex DNA mixtures. Will also work to detect very rare mutations from this enriched material on the Next Generation Sequencers. Possibility for more senior position for exceptionally qualified applicants....

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