Cholangiocytes - Nicholas F. LaRusso

Overview

The objectives of my laboratory are to apply the fundamental concepts and broad technologies of cell/molecular biology to understand hepatic epithelial cell function and dysfunction. Our focus is principally on cholangiocytes (epithelial cells that line intrahepatic bile ducts) because of their biologic and clinical importance, the new hypotheses and techniques we have developed for their study, and the role we have played in advancing cholangiocyte pathobiology — an underserved area of research. Currently, my lab has two major parallel programs focused on cholangiocyte pathobiology, each supported by an R01 grant from NIH.

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