Dr. LaRusso's Cholangiopathies Laboratory has two major parallel programs focused on cholangiocyte pathobiology, each supported by an R01 grant from the National Institute of Diabetes and Digestive and Kidney Diseases.
Cyst and cystic diseases
One program of the Cholangiopathies lab is cholangiociliopathies, a group of incurable genetic diseases manifesting as biliary cysts with or without fibrosis. Autosomal recessive and autosomal dominant polycystic kidney disease are two examples of cholangiociliopathies that the lab studies.
The Cholangiopathies lab has shown that:
The second program of the Cholangiopathies lab is the interaction between cholangiocytes and Cryptosporidium parvum (C. parvum), an emerging pathogen that causes intestinal and biliary cryptosporidiosis.
Recent evidence from the Cholangiopathies lab indicates that:
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