Selected Publications

View complete list

1. Cheng Z-J, Miller LJ. Agonist-dependent dissociation of oligomeric complexes of G protein-coupled cholecystokinin receptors demonstrated in living cells using bioluminescence resonance energy transfer. J Biol Chem 276:48040-48047, 2001.
2. Ding X-Q, Pinon DI, Furse KE, Lybrand TP, Miller LJ. Refinement of the conformation of a critical region of charge-charge interaction between cholecystokinin and its receptor. Mol Pharmacol 61:1041-1052, 2002.
3. Ding W-Q, Kuntz S, Böhmig M, Wiedenmann B, Miller LJ. Dominant negative action of an abnormal secretin receptor arising from mRNA missplicing in a gastrinoma. Gastroenterology 122:500-511, 2002.
4. Matsuura B, Dong M, Miller LJ. Differential determinants for peptide and non-peptide ligand binding to the motilin receptor. Critical role of second extracellular loop for peptide binding and action. J Biol Chem 277:9834-9839, 2002.
5. Harikumar KG, Pinon DI, Wessels WS, Prendergast FG, Miller LJ. Environment and mobility of a series of fluorescent reporters at the amino-terminus of structurally-related peptide agonists and antagonists bound to the cholecystokinin receptor. J Biol Chem 277:18552-18560, 2002.
6. Ding WQ, Cheng ZJ, McElhiney J, Kuntz SM, Miller LJ. Silencing of secretin receptor function by dimerization with a misspliced variant secretin receptor in ductal pancreatic adenocarcinoma. Cancer Res 62:5223-5229, 2002.
7. Zang M, Dong M, Pinon DI, Ding X-Q, Hadac EM, Miller LJ. Spatial approximation between a photolabile residue in position 13 of secretin and the amino terminus of the secretin receptor. Mol Pharmacol 63:993-1001, 2003.
8. Dong M, Li Z, Zang M, Pinon DI, Lybrand TP, Miller LJ. Spatial approximation between two residues in the mid-region of secretin and the amino terminus of its receptor. Incorporation of seven sets of such constraints into a three-dimensional model of the agonist-bound secretin receptor. J Biol Chem 278:48300-48312, 2003.
9. Cheng Z-J, Harikumar KG, Holicky EL, Miller LJ. Heterodimerization of type A and B cholecystokinin receptors enhance signaling and promote cell growth. J Biol Chem 278:52972-52979, 2003.
10. Harikumar KG, Pinon DI, Wessels WS, Dawson ES, Lybrand TP, Prendergast FG, Miller LJ. Measurement of intermolecular distances for the natural agonist peptide docked at the cholecystokinin receptor expressed in situ using fluorescence resonance energy transfer. Mol Pharmacol 65:28-35, 2004.
11. Dong M, Li Z, Pinon DI, Lybrand TP, Miller LJ. Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor. J Biol Chem 279:2894-2903, 2004.
12. Dong M, Pinon DI, Cox RF, Miller LJ. Molecular approximation between a residue in the amino-terminal region of calcitonin and the third extracellular loop of the class B G protein-coupled calcitonin receptor. J Biol Chem 279:31177-31182, 2004.
13. Arlander SJH, Dong M, Ding X-Q, Pinon DI, Miller LJ. Key differences in molecular complexes of the cholecystokinin receptor with structurally-related peptide agonist, partial agonist, and antagonist. Focus on importance of sulfation of tyrosine in peptide position 27. Mol Pharmacol 66:545-552, 2004.
14. Dong M, Pinon DI, Cox RF, Miller LJ. Importance of the amino terminus in secretin family G protein-coupled receptors. Intrinsic photoaffinity labeling establishes initial docking constraints for the calcitonin receptor. J Biol Chem 279:1167-1175, 2004.
15. Harikumar KG, Puri V, Singh R, Hanada K, Pagano RE, Miller LJ. Differential effects of modification of membrane cholesterol and sphingolipids on the conformation, function, and trafficking of the G protein-coupled cholecystokinin receptor. J Biol Chem 280:2176-2185, 2005.
16. Lisenbee CS, Dong M, Miller LJ. Paired cysteine mutagenesis to establish the pattern of disulfide bonds in the functional intact secretin receptor. J Biol Chem 280:12330-12338, 2005.
17. Dong M, Liu G, Pinon DI, Miller LJ. Differential docking of high affinity peptide ligands to type A and B cholecystokinin receptors demonstrated by photoaffinity labeling. Biochemistry 44:6693-6700, 2005.
18. Dong M, Hadac EM, Pinon DI, Miller LJ. Differential spatial approximation between cholecystokinin residue 30 and receptor residues in active and inactive conformations. Mol Pharmacol 67:1892-1900, 2005.
19. Harikumar KG, Morfis MM, Lisenbee CS, Sexton PM, Miller LJ. Constitutive formation of oligomeric complexes between Family B G protein-coupled vasoactive intestinal polypeptide and secretin receptors. Mol Pharmacol 69:363-373, 2006.
20. Harikumar KG, Hosohata K, Pinon DI, Miller LJ. Use of probes with fluorescence indicator distributed throughout the pharmacophore to examine the peptide agonist-binding environment of the Family B G protein-coupled secretin receptor. J Biol Chem 281:2543-2550, 2006.
21. Hadac EM, Dawson ES, Darrow JW, Sugg EE, Lybrand TP, Miller LJ. Novel benzodiazepine photoaffinity probe stereoselectively labels a site deep within the membrane-spanning domain of the cholecystokinin receptor. J Med Chem 49:850-863, 2006.
22. Dong M, Pinon DI, Asmann Y, Miller LJ. Possible endogenous agonist mechanism for activation of secretin family G protein-coupled receptors. Mol Pharmacol 70:206-213, 2006.
23. Harikumar KG, Pinon Di, Miller LJ. Fluorescent indicators distributed throughout the pharmacophore of cholecystokinin provide insights into distinct modes of binding and activation of type A and B cholecystokinin receptors. J Biol Chem 281:27072-27080, 2006.
24. Harikumar KG, Dong M, Cheng Z, Pinon DI, Lybrand TP, Miller LJ. Transmembrane segment peptides can disrupt cholecystokinin receptor oligomerization without affecting receptor function. Biochemistry 45:14706-14716, 2006.
25. Dong M, Ding X-Q, Thomas SE, Gao F, Lam PCH, Abagyan R, Miller LJ. Role of lysine187 within the second extracellular loop of the type A cholecystokinin receptor in agonist-induced activation. Use of complementary charge-reversal mutagenesis to define a functionally-important interdomain interaction. Biochemistry 46:4522-4531, 2007.
26. Dong M, Lam PCH, Gao F, Hosohata K, Pinon DI, Sexton P, Abagyan R, Miller LJ. Molecular approximations between residues 21 and 23 of secretin and its receptor. Use in developing a model for peptide docking with the amino terminus of the secretin receptor. Mol Pharmacol 72:280-290, 2007.
27. Hayes GM, Carrigan PE, Dong M, Reubi J-C, Miller LJ. A novel secretin receptor splice variant potentially useful for the early diagnosis of pancreatic carcinoma. Gastroenterology 133:853-861, 2007.
28. Harikumar KG, Pinon DI, Miller LJ. Transmembrane segment IV contributes a functionally important interface for oligomerization of the Class II G protein-coupled secretin receptor. J Biol Chem 282:30363-30372, 2007.
29. Harikumar KG, Dong M, Lam PCH, Sexton P, Abagyan R, Miller LJ. Fluorescence resonance energy transfer analysis of secretin docking to its receptor. Mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues. J Biol Chem 282:32834-32843, 2007.
30. Carrigan PE, Hentz JG, Gordon G, Morgan JL, Raimondo M, Anbar AD, Miller LJ. Distinctive heavy metal composition of pancreatic juice in patients with pancreatic carcinoma. Cancer Epidemiol Biomarkers Prev 16:2656-2663, 2007.