Areas of Research

• Pharmacogenomics (molecular basis of individual variation in response to drugs)
• Cause and effects of DNA instability in human disease
• Supercomputer-based approaches to rational drug design
• Spectroscopic studies of protein folding and host-ligand interactions
• Interaction of drugs and hormones with the genome, biology, and toxicology of the cholinergic synapse
• Cell signaling in G-protein and tyrosine kinase receptor systems
• Mechanisms of novel cancer chemotherapeutics
• Molecular biology of alcohol metabolism
• Cellular and molecular biology of cardioprotection