PROJECT LIST

1. Responsive Brain Stimulation Clinical Trials
   Funding Source: NeuroPace Inc.
   
   1. Responsive Neurostimulator (RNS™) System Long-Term Treatment Clinical Investigation (9/2006-9/2008) — Primary Investigator: Gregory A. Worrell, MD, Ph.D.
   The goal of this research is to demonstrate that the NeuroPace Responsive Neurostimulator can safely deliver responsive electrical stimulation to reduce seizures.
2. Seizure Advisory System
   Funding Source: NeuroVista Inc.
   
   1. Preclinical development stage
   2. Goal of clinical trial commencement before the end of 2009
   The goal of this research is to demonstrate that a continuous metric of intracranial EEG activity can be used to provide seizure likelihood information to patients, so that they adjust their activities accordingly.
3. High Spatiotemporal Resolution EEG
   Funding Source: NIH
   
   1. High & low frequency field potential signatures of epileptogenic brain are quantitated and analyzed for their ability to spatially localize seizure onset zones in partial epilepsy
   2. The same signatures of epileptogenic brain are quantitated and analyzed for to their ability to temporally localize seizure onset times
   3. Extracellular action potential (unit) firing rates are quantitated relative to human clinical seizure onsets
4. Large-scale Electrophysiology Database and Informatics
   In collaboration with Brian Litt at University of Pennsylvania we are creating a database of intracranial EEG that will be made available to the international community of researchers working in the field of seizure prediction.
5. Field Potential Correlates of Memory
   
   1. Time/frequency analyses of laptop-based memory tasks synced to intracranial EEG
6. Statistical Parametric Mapping of Paired Ictal/interictal SPECT Images for Anatomic Localization in Epilepsy & Movement disorders