Polycystic Kidneys and Other Inherited Renal Diseases
Achievements by Mayo researchers in polycystic kidney disease have had direct impact on patient care. These include the identification of the major gene for the most common genetic disease of the kidney, autosomal dominant polycystic kidney disease (ADPKD), and the gene responsible for the devastating infantile form of the disease, autosomal recessive polycystic kidney disease (ARPKD). Mayo researchers have also played a leading role in the development of large multicenter clinical trials for ADPKD (CRISP, HALT PKD) and the identification of a potentially safe and effective treatment for this disorder (vasopressin V2 receptor antagonist). Clinical trials with this drug are currently under development.
The pathogenesis and genetics of Polycystic Kidney and Liver Disease, and the mechanisms of cyst formation
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Mayo scientists and nephrologists are conducting basic research to investigate the molecular genetics of familial forms of glomerulonephritis including focal and segmental glomerulosclerosis (FSGS).
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