| ||||
NEWS, PUBLICATIONS, AND RELATED STORIES Discovery's Edge - Mayo's Research Publication What causes brain tumors? Using statistics from Mayo’s enormous patient databases, genetics researchers are learning how genetic mutations and environmental triggers increase the risk of developing brain cancer. View Related  PCNSL most often affects the elderly, people who are immunosuppressed because of illness or transplant, and patients with AIDS. Though uncommon, this tumor is increasing in incidence, even in patients without known risk factors. View Abstract  Offering cancer patients in Florida and the Southeast access to investigational therapies through rigorously monitored clinical trials "The cancer field is rapidly moving to use of these new agents as a way to improve upon the success we have seen with more traditional therapies, such as chemotherapy and radiation," says says Michael Menefee, M.D., who heads the Phase I Clinical Trial Program in Oncology at Mayo Clinic, Jacksonville. View Related  Mayo Clinic Cancer Center receives an additional five years of National Cancer Institute (NCI) funding and re-designation as a comprehensive cancer center. Mayo Clinic researchers and colleagues at the University of California San Francisco (UCSF) have found a connection between DNA alterations on human chromosome 9 and aggressive brain cancer known as glioblastoma. The findings are reported in the current online issue of Nature Genetics. View Abstract  Patient Story -- Kathy Crandall Successful brain tumor treatment at Mayo Clinic starts Kathy Crandall on a new path in life. View Related  Patients who had aggressive surgeries were free of tumor recurrence an average of 15 years after diagnosis If safely removing the entire tumor was not possible, patients survived significantly longer when surgery was followed by radiation therapy. This study is available online in Neuro-Oncology. View Abstract  Patient Story -- Andy Walch Surgery and an investigational drug give brain tumor patient much more than anyone expected. View Related  William C. Rupp, M.D., has been appointed CEO for the Florida campus effective Nov. 21, Mayo Clinic announced today. Rupp currently leads quality projects for Luther Midelfort, part of Mayo Health System, as well as Mayo Clinic.  Patient Story -- Grace Phillips Brain tumor surgery at Mayo Clinic in 1932 helped Grace Phillips live an extraordinary life. View Related  Patient Story -- Cynthia Amendt Artist and teacher Cynthia Amendt sees her teaching — and her health — reach new levels through participation in a clinical trial. View Related  Patient Story -- Nelda Metz Nelda Metz had been healthy all of her 49 years. Imagine her surprise, when she learned she had a malignant brain tumor. View Related  Patient Story -- Margie Hartmann and Jessica Nastrom Shopping, going to lunch, seeing a movie — just a few things mothers and daughters do together. Add having Gamma Knife™ surgery to the list for Margie Hartmann and her daughter, Jessica Nastrom. View Related  Patient Story -- Emily Crawford Emily Crawford's summer vacation included an unexpected event — brain tumor surgery at Mayo Clinic. View Related  Patient Story -- Emmy Holliday Clinical trials have given hope and time to Emmy Holliday. View Related   Patient Story -- Jackson Hoeger After fighting cancer for four years, Jackson Hoeger and his family finally feel like they've graduated from the school of hard knocks. View Related  Patient Story -- Jayden Aldona Gonzalez When a brain tumor unexpectedly appeared in 20-month-old Jayden Gonzalez, Mayo Clinic doctors responded quickly to remove the tumor and restore his health. View Related  Mayo Clinic is collaborating with the University of Minnesota to identify tell-tale genes that would reveal cancerous tumors in the brain. "Already, we have identified almost two dozen primary brain tumors that appear to have been induced by a gene mutation that we introduced into our mouse models," said Robert Jenkins, M.D., Ph.D., of Mayo Clinic. While that is a remarkable discovery, he said, the tumors must be more fully studied to determine precise, genetically relevant information. View Related  Patient Story -- Carolyn Lengh Carolyn Lengh, a principal at a private school in Milwaukee, knows the wear and tear countless hours in a demanding job can cause. View Related Agreement strengthens relationship and spawns new scientific collaborations "TGen takes seriously our commitment to work toward helping patients with cancer and other disorders. This announcement is another mechanism allowing TGen and Mayo faculty to work bi-directionally in a more seamless fashion," said Jeffrey Trent, Ph.D., TGen's president and scientific director. View Related  Patient Story -- Laurie Beach A rare brain tumor couldn't stop Laurie Beach from enjoying the life she dreamed of. View Related  News from Rochester, Minn. Stereotactic radiosurgery uses precisely focused radiation to treat tumors and other abnormal growths in the brain. View Related  Presented at the annual meeting of the American Society for Therapeutic Radiation and Oncology (ASTRO) "Most of these patients don't have other effective treatment options, because surgery is not possible if there are multiple tumors in their liver," says the study's lead investigator, Laura Vallow, M.D. "But with this radiotherapy, no new tumors developed in patients who responded and we find this to be very encouraging." View Related  New vaccine for glioblastoma multiforme, an aggressive brain cancer, is now being offered through a clinical trial at Mayo Clinic in Jacksonville. The vaccine represents a fresh and fairly simple approach to treating this cancer, says neurosurgeon Kent New, M.D., Ph.D., who will be leading the study at Mayo. About 40 percent of these tumors display a particular protein on their surface and the vaccine is designed to trick the patient's immune system into thinking the protein is "foreign" in order to mount a killing response. View Related        Jacksonville, Fla. This technology, an intraoperative Magnetic Resonance Imaging (MRI) system known as the IMRIS Neuro system, allows surgeons to use real-time imaging as they operate and uses a unique ceiling-mounted track that moves the MRI system to the patient rather than the patient having to be moved to the magnet. View Related    Mayo Clinic Cancer Center had researchers from many disciplines presenting more than 60 oral abstracts and dozens of posters, also educational sessions and other special events throughout the 2007 ASCO program, June 1-5. View Related  The National Institutes of Health chose Mayo Clinic as one of the first 12 institutions to receive Clinical and Translational Science Awards (CTSA) in October 2006. "There are two objects in medical education: to heal the sick and advance the science." - Dr. Charles H. Mayo  Yuan-Ping Pang, Ph.D. established the Computer-Aided Molecular Design Laboratory (CAMDL) to learn more about how biological systems function and to establish models that could lead to new treatments for infectious diseases and cancer. View Related  Special Event: June 3, 2007 -- Rochester, Minn. "This celebration of life is for everyone," says Janine Kokal, local planning committee chair and a Mayo Clinic nurse educator. This is a free event, but reservations are required by May 28, 2007. To register, call the American Cancer Society at 507-424-4602 or 1-888-535-4227 (toll free). View Related  "This new technology allows a multidisciplinary approach to be performed safely in these rare tumors that were once considered unresectable." View Abstract  Intent on incorporating the patient's voice into cancer research and care, Mayo Clinic Cancer Center investigators have sought out the best practices, promising techniques and novel applications for quality of life (QOL) assessment. "We expect that QOL assessments will someday become as routine as having your blood pressure checked," says Dr. Jeff Sloan. "After all, if the best interests of the patient are what we seek, incorporating their needs into regular care is imperative." View Abstract  Publication: Journal of Clinical Oncology -- Dec. 1, 2006 North Central Cancer Treatment Group View Related  Seeking a cure for glioblastoma multiforme, other deadly cancers Mayo Clinic is unique in its pursuit of oncolytic measles vaccine strains for cancer treatment, and the research has grown from the most basic laboratory science to the sophisticated therapy being tested today in several tumor types, including glioblastoma multiforme, recurrent ovarian cancer and multiple myeloma. View Related  The Magnetic Resonance (MR) lab at Mayo Clinic has invented new MR technologies that have been incorporated into every MR scanner in the world. Their inventions help millions of people. And MR investigators work closely with their clinical colleagues to bring state-of-the-art biotechnology to patient care in record time. It's a dynamic lab that has earned an international reputation for continually finding novel ways to use imaging. This article describes some of those novel technologies, the MR lab's past achievements, current projects and an enticing look into what we can expect from this dynamic lab in the future. View Related  More than 200 clinicians and researchers attended the 2nd Mayo Clinic Angiogenesis Symposium, Oct. 27-29, 2006. Angiogenesis is the specific growth of new blood vessels to accommodate tumor growth and the spread of many cancers. View Related  Publication: Cancer Research -- Oct. 15, 2006 Combined deletion of chromosomes 1p and 19q is associated with improved prognosis and responsiveness to therapy in patients with anaplastic oligodendroglioma. Jenkins et al. used stem cell culture techniques to recover a t(1;19)(q10;p10) from an oligodendroglioma, suggesting that the translocation likely mediates the combined 1p and 19q deletions. The authors then developed an interphase fluorescence in situ hybridization (FISH) strategy to detect the t(1;19) in paraffin-embedded tumors. Using gliomas from patients enrolled on NCCTG trials, the FISH test demonstrated that the translocation is highly prevalent in oligodendrogliomas and is associated with superior survival. View Related Mayo Awarded $72 Million for Clinical and Translational Research "The Mayo Clinic Center for Clinical and Translational Research will coordinate the efforts of our outstanding clinical research education and training programs, our world-class scientists and clinical research investigators, and the vast resources of Mayo Clinic to speed the process of turning our research discoveries into the medications and treatments our patients need and expect," says Robert Rizza, M.D., Mayo Clinic's director for research and the director of the new center. View Related  The Clinical Research Training Program provides a formal education in all aspects of clinical research, including grant-writing, legal and ethical issues, statistics, epidemiology and study design and protocols. "I realized how exciting research can be, and how exciting it is to advance the science." Jon Ebbert, M.D. View Related  Publication: Journal of Clinical Oncology -- Aug. 20, 2006 North Central Cancer Treatment Group along with Southwest Oncology Group View Related  "This collaboration will enable us to work with the Indian Health Service to address health care-related needs specific to Native Americans, ranging from developing research initiatives to address unique problems, to finding ways to improve access to medi View Related In helping young investigators, Mayo Clinic again is connecting all the dots -- leading back to the same point, the same mission, ongoing and yet unchanged for over a century: the needs of the patient come first. New, young investigators are critical to biomedical research. Their fresh ideas, innovativeness, and enthusiasm are necessary for scientific progress. Yet the steps from a junior research position toward a self-sufficient laboratory can be difficult. Mayo Clinic is dedicated to fostering future, investigators. Here we look at two of them and what Mayo is doing to help. View Related  Robert B. Diasio, M.D., has been appointed Mayo Clinic Cancer Center Director, succeeding Franklyn Prendergast, M.D., Ph.D. Dr. Diasio, who will be based at Mayo Clinic in Rochester, will also direct cancer center activities at Mayo Clinic in Arizona and Mayo Clinic in Jacksonville, Fla. View Related State and regional cancer survivors, their families and friends will come together to celebrate life during the upcoming 19th annual National Cancer Survivors Day Celebration, Sunday, June 4, 2006. "This celebration of life is for everyone," says Janine Kokal, Mayo Clinic nurse educator and local planning committee chair. "Whether you're a cancer survivor, a family member, a friend or a medical professional, National Cancer Survivors Day provides an opportunity for cancer survivors to connect with other survivors, and reunite with medical staff and families they've met along the way." View Related  Medical Edge Newspaper First, a cancer diagnosis. Then, worries about possible side effects from the treatment -- the nausea and vomiting you've heard about from others who have been treated for cancer. This article explores some of the options available for dealing with the side effects of treatment. View Related The first radiation therapy and respiratory care baccalaureate classes of Mayo School of Health Sciences and the University of Minnesota will be conferred on Friday, May 12, 2006, at Mayo Clinic. View Related Now that this signal has been identified, new strategies can be generated for enhancing the ability of the immune system to kill tumor cells in patients with cancer. "Because NK cells can communicate different messages -- one that serves health by clearing tumors and viruses and one that serves disease by blocking the response to cancer -- understanding which signals result in effective tumor clearance is a high priority for those of us fighting cancer," explains Paul Leibson, M.D., Ph.D., the Mayo Clinic immunologist and pediatrician who led the study. View Abstract Mayo Clinic researchers have discovered clues about new molecular partnerships involving a key protein that naturally guards against cancer because it promotes repair of damaged DNA. Research shows that loss of p53 is directly related to cancer. People born without enough p53 function get spontaneous cancers. In about half of all cancers, the two genes that give the instructions for making p53 (each person gets one gene from each parent) are missing or shut off. This suggests that loss of p53 function is a common event in the origin of many different kinds of cancer. Therefore, an appealing research strategy is to devise ways to restore or protect p53 function. Discovering all the ways p53 gets turned on is an important first step toward doing that. View Abstract Mayo Clinic researchers have uncovered a new cellular secret that may explain how certain cancers move and spread -- a feature of cancers that makes treatment especially difficult. "These findings have broad implications toward the general understanding of how specific processes in the wave may affect such things as cell growth, cell movement and metastasis," explains Mark McNiven, Ph.D., the lead researcher on the Mayo Clinic team. "Our work provides new insights into a novel mechanism by which cells can internalize growth factor information. Understanding this process is the first step toward one day halting it, preventing it or reversing it therapeutically." View Related  Mayo Clinic broke ground this morning for a new building to house advanced imaging research. Mayo received a gift of $7 million from The Opus Group to support construction of the facility. "Much of medicine in the future will depend heavily on noninvasive imaging techniques," says Denis Cortese, M.D., CEO of Mayo Clinic. "We are grateful for this generous gift from Opus, which will help us expand both our diagnostic and treatment capabilities through the findings of this research. Applying basic science research findings to patient care is what we do best, and we look for this activity to keep Mayo Clinic on the cutting edge of imaging." View Related  Mayo Clinic’s Molecular Medicine Program has three gene therapy clinical trials open in which the entire preclinical cycle—concept, discovery of agent, vector manufacture, toxicology and efficacy studies, and new drug application—was conducted at Mayo The projects engineered strains of the measles virus, MV-CEA and MV-NIS, which kill multiple cancer cells, and can be monitored easily. The open trials are in ovarian cancer, glioblastoma multiforme (brain cancer), and multiple myeloma. This article discusses the general research and the first trial which opened -- ovarian cancer. The projects are a fine example of a clear translational effort from bedside to bench and back to the bedside. View Related In terms of a medical diagnosis, nothing is more devastating than hearing the "C" word - cancer. But now, ASU and Mayo Clinic are hoping that five different C's will become the best arsenal against the big C. The organizations have teamed up to introduce a new research entity called MAC5. MAC5 is short for the Mayo Clinic - ASU Center for Cancer-related Convergence, Cooperation and Collaboration. View Related  Medical Edge Television He's a world-class martial arts champion. But his strength could not fend off a deadly cancer. A cancer that causes debilitating pain. It took some intense detective work by doctors at Mayo Clinic to make the diagnosis and find a treatment that would keep this athlete alive. Read Script  Publication: Journal of Clinical Oncology -- Aug. 10, 2005 A North Central Cancer Treatment Group Study View Related     Publication: Journal of Clinical Oncology -- June 15, 2004 North Central Cancer Treatment Group with National Cancer Institute of Canada View Related  |
Legal restrictions and terms of use applicable to this site
Use of this site signifies your agreement to the terms of use
Copyright © 2009 Mayo Foundation for Medical Education and Research.