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News, Publications, and Related Stories
Cancer Research -- May 1, 2010 
Discovery's Edge - Mayo's Research Publication What causes brain tumors? Using statistics from Mayo’s enormous patient databases, genetics researchers are learning how genetic mutations and environmental triggers increase the risk of developing brain cancer. View Related 
PCNSL most often affects the elderly, people who are immunosuppressed because of illness or transplant, and patients with AIDS. Though uncommon, this tumor is increasing in incidence, even in patients without known risk factors. View Abstract
Offering cancer patients in Florida and the Southeast access to investigational therapies through rigorously monitored clinical trials "The cancer field is rapidly moving to use of these new agents as a way to improve upon the success we have seen with more traditional therapies, such as chemotherapy and radiation," says says Michael Menefee, M.D., who heads the Phase I Clinical Trial Program in Oncology at Mayo Clinic, Jacksonville. View Related 
Mayo Clinic Cancer Center receives an additional five years of National Cancer Institute (NCI) funding and re-designation as a comprehensive cancer center.
Mayo Clinic researchers and colleagues at the University of California San Francisco (UCSF) have found a connection between DNA alterations on human chromosome 9 and aggressive brain cancer known as glioblastoma. The findings are reported in the current online issue of Nature Genetics. View Abstract 
Patients who had aggressive surgeries were free of tumor recurrence an average of 15 years after diagnosis If safely removing the entire tumor was not possible, patients survived significantly longer when surgery was followed by radiation therapy. This study is available online in Neuro-Oncology. 
Patient Story -- Andy Walch Surgery and an investigational drug give brain tumor patient much more than anyone expected. View Related
Publication: The Journal of Cell Biology -- Nov. 17, 2008 
William C. Rupp, M.D., has been appointed CEO for the Florida campus effective Nov. 21, Mayo Clinic announced today. Rupp currently leads quality projects for Luther Midelfort, part of Mayo Health System, as well as Mayo Clinic. 
Patient Story -- Cynthia Amendt Artist and teacher Cynthia Amendt sees her teaching — and her health — reach new levels through participation in a clinical trial. View Related 
Patient Story -- Margie Hartmann and Jessica Nastrom Shopping, going to lunch, seeing a movie — just a few things mothers and daughters do together. Add having Gamma Knife™ surgery to the list for Margie Hartmann and her daughter, Jessica Nastrom. View Related 
Patient Story -- Emily Crawford Emily Crawford's summer vacation included an unexpected event — brain tumor surgery at Mayo Clinic. View Related
Patient Story -- Jackson Hoeger After fighting cancer for four years, Jackson Hoeger and his family finally feel like they've graduated from the school of hard knocks. View Related 
Patient Story -- Jayden Aldona Gonzalez When a brain tumor unexpectedly appeared in 20-month-old Jayden Gonzalez, Mayo Clinic doctors responded quickly to remove the tumor and restore his health. View Related 
Mayo Clinic is collaborating with the University of Minnesota to identify tell-tale genes that would reveal cancerous tumors in the brain. "Already, we have identified almost two dozen primary brain tumors that appear to have been induced by a gene mutation that we introduced into our mouse models," said Robert Jenkins, M.D., Ph.D., of Mayo Clinic. While that is a remarkable discovery, he said, the tumors must be more fully studied to determine precise, genetically relevant information. View Related
Agreement strengthens relationship and spawns new scientific collaborations "TGen takes seriously our commitment to work toward helping patients with cancer and other disorders. This announcement is another mechanism allowing TGen and Mayo faculty to work bi-directionally in a more seamless fashion," said Jeffrey Trent, Ph.D., TGen's president and scientific director. View Related 
Patient Story -- Laurie Beach A rare brain tumor couldn't stop Laurie Beach from enjoying the life she dreamed of. View Related 
News from Rochester, Minn. Stereotactic radiosurgery uses precisely focused radiation to treat tumors and other abnormal growths in the brain. View Related
Mayo Clinic Cancer Center had researchers from many disciplines presenting more than 60 oral abstracts and dozens of posters, also educational sessions and other special events throughout the 2007 ASCO program, June 1-5. View Related 
The National Institutes of Health chose Mayo Clinic as one of the first 12 institutions to receive Clinical and Translational Science Awards (CTSA) in October 2006. "There are two objects in medical education: to heal the sick and advance the science." - Dr. Charles H. Mayo 
Yuan-Ping Pang, Ph.D. established the Computer-Aided Molecular Design Laboratory (CAMDL) to learn more about how biological systems function and to establish models that could lead to new treatments for infectious diseases and cancer. View Related
Publication: Journal of Clinical Oncology -- Dec. 1, 2006 North Central Cancer Treatment Group View Related
The Magnetic Resonance (MR) lab at Mayo Clinic has invented new MR technologies that have been incorporated into every MR scanner in the world. Their inventions help millions of people. And MR investigators work closely with their clinical colleagues to bring state-of-the-art biotechnology to patient care in record time. It's a dynamic lab that has earned an international reputation for continually finding novel ways to use imaging. This article describes some of those novel technologies, the MR lab's past achievements, current projects and an enticing look into what we can expect from this dynamic lab in the future. View Related 
Publication: Cancer Research -- Oct. 15, 2006 Combined deletion of chromosomes 1p and 19q is associated with improved prognosis and responsiveness to therapy in patients with anaplastic oligodendroglioma. Jenkins et al. used stem cell culture techniques to recover a t(1;19)(q10;p10) from an oligodendroglioma, suggesting that the translocation likely mediates the combined 1p and 19q deletions. The authors then developed an interphase fluorescence in situ hybridization (FISH) strategy to detect the t(1;19) in paraffin-embedded tumors. Using gliomas from patients enrolled on NCCTG trials, the FISH test demonstrated that the translocation is highly prevalent in oligodendrogliomas and is associated with superior survival. View Related
The Clinical Research Training Program provides a formal education in all aspects of clinical research, including grant-writing, legal and ethical issues, statistics, epidemiology and study design and protocols. "I realized how exciting research can be, and how exciting it is to advance the science." Jon Ebbert, M.D. View Related 
Publication: Journal of Clinical Oncology -- Aug. 20, 2006 North Central Cancer Treatment Group along with Southwest Oncology Group View Related
In helping young investigators, Mayo Clinic again is connecting all the dots -- leading back to the same point, the same mission, ongoing and yet unchanged for over a century: the needs of the patient come first. New, young investigators are critical to biomedical research. Their fresh ideas, innovativeness, and enthusiasm are necessary for scientific progress. Yet the steps from a junior research position toward a self-sufficient laboratory can be difficult. Mayo Clinic is dedicated to fostering future, investigators. Here we look at two of them and what Mayo is doing to help. View Related
Mayo Clinic’s Molecular Medicine Program has three gene therapy clinical trials open in which the entire preclinical cycle—concept, discovery of agent, vector manufacture, toxicology and efficacy studies, and new drug application—was conducted at Mayo The projects engineered strains of the measles virus, MV-CEA and MV-NIS, which kill multiple cancer cells, and can be monitored easily. The open trials are in ovarian cancer, glioblastoma multiforme (brain cancer), and multiple myeloma. This article discusses the general research and the first trial which opened -- ovarian cancer. The projects are a fine example of a clear translational effort from bedside to bench and back to the bedside. 
Medical Edge Television He's a world-class martial arts champion. But his strength could not fend off a deadly cancer. A cancer that causes debilitating pain. It took some intense detective work by doctors at Mayo Clinic to make the diagnosis and find a treatment that would keep this athlete alive.
Publication: Journal of Clinical Oncology -- Aug. 10, 2005 A North Central Cancer Treatment Group Study View Related
Publication: Journal of Clinical Oncology -- June 15, 2004 North Central Cancer Treatment Group with National Cancer Institute of Canada View Related
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