The NMR Facility at Mayo currently supports three main fields of NMR biomedical application: Study of the structure of biomacromolecules in solution by high field, high resolution NMR spectroscopy:
For example, we are currently investigating how the drug levamisole helps the drug 5-FU extend the life of some patients who have undergone surgery for colon cancer. For those studies, we use nuclear magnetic resonance spectroscopy and follow the behavior of the drugs in human colon cancers growing in mice. We are monitoring the nuclear magnetic resonance signal of phosphorous and fluorine nuclei in tumor xenografts in mice. Phosphorous is a natural part of living systems. Fluorine is a major component of the drug 5-FU. By phosphorous NMR, we follow the viability of tumor cells and by fluorine NMR, the concentration and metabolism of the added drug 5-FU. The results of these studies will help determine how the two drugs interact in the body and may eventually lead to further improvements in therapy.
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