C. Elegans PKD-targeted Services
As it is extremely difficult to study cilia biology and the connections among cilia formation, sensory function and disease in mammalian model organisms, alternative experimental systems such as C. elegans are necessary. C. elegans — with its evolutionarily conserved PKD genes, polycystin ciliary localization and polycystin sensory function — is a powerful model for characterizing the physiological roles of PKD genes in their native cellular environment.
The Model Systems Core offers five C. elegans PKD-targeted services:
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