Pharmacogenomics Bioinformatics Fellowship. The Pharmacogenomics Laboratory at the Mayo Clinic College of Medicine is seeking a postdoctoral fellow with a Ph.D., M.D. or M.D.-Ph.D. degree for a position as a 'Pharmacogenomics Bioinformatics' fellow. This laboratory is part of the NIH-sponsored Pharmacogenomics Research Network (PGRN) and our studies involve very large datasets that include genomic, transcriptomic and metabolomic data, as well as both cell line-based and clinical drug response ...

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A two-year research associate position is available in the Epidemiology and Genetics of Lung Cancer Research Program, Division of Epidemiology, Mayo Clinic Rochester. This program utilizes various modern techniques and approaches in the framework of classic clinical epidemiology, with a broad range of research directions and resources, from genetic and molecular epidemiology, pharmacogenetic epidemiology, clinical outcomes and quality of life research, and bioinformatics. NIH funded-ongoing stu...

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The insulin/IGF pathway is a central regulator of health and longevity in diverse organisms from C. elegans and Drosophila to mice and humans. We have discovered that the IGF-1 receptor is controlled by an embryonic isoform of the tumor suppressor p53. We have ARRA funds to support at least one new postdoc to work out the molecular mechanism by which p53 controls IGF-1 receptor expression and signaling. Mouse experience necessary. Additional knowledge of at least the rudiments of mouse embry...

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Postdoctoral positions are available immediately in the Departments of Medicine and Biochemistry/Molecular Biology to investigate the action of transforming growth factor beta (TGF-β). Research topics include (i) characterizing the cellular machinery and receptor elements mediating TGF-βR downregulation, recycling, and polarized epithelial cell trafficking; (ii) delineating the function of Erbin and the NF2 tumor suppressor Merlin in controlling cell type-specific TGF-β signali...

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We have an opening for a self-motivated post-doctoral fellow to start in 2010 in an NIH-funded (new R01) position to examine the role of the transcriptional repressor NKAP in T cell development. This work will focus on extending our recently published work (Pajerowski, A.G., Nguyen, C.T., Shapiro, M.J., and Shapiro, V.S. (2009) NKAP is a transcriptional repressor of Notch signaling and is required for T cell development. Immunity. 30(5): 696-707.) These studies will focus on epigenetic alt...

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Loss of brain function is arguably the most dreaded consequence of getting old. We propose to test the hypothesis that restoration of youthful levels of mechano growth factor (MGF) will arrest the decline in adult neurogenesis that is linked to loss of brain function in old individuals. We will take advantage of an inducible gene expression system that utilizes control elements from the lac operon of E. coli to induce or repress transgene expression in the mouse. We will ask two questions: 1)...

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A postdoctoral position is available immediately in the Division of Hematology Research, Mayo Clinic Rochester. The fellow will join a highly interactive and collaborative research team that focuses on translational research in B cell malignancies. Current studies are specifically focused on (i) the role of TNF family members on the survival and progression of B cell lymphomas, (ii) the study of signaling pathways involved in B cell transformation, and (iii) characterization of genetic alterati...

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The Pulmonary Cell Biology laboratory has an opening for a full time Post Doctoral Research Fellow in lung cellular physiology. The laboratory is generally focused on the mechanisms underlying normal function of the airway and pulmonary vasculature, and the pathophysiological mechanisms of disease (e.g. asthma, bronchopulmonary dysplasia, pulmonary hypertension). The research is conducted by a multidisciplinary group of scientists and physicians with strong emphasis on cellular imaging (fluo...

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The Cardiovascular Molecular Imaging laboratory has an opening for a full time Post Doctoral Research Fellow. The main objective of the study is to elucidate the mechanism that regulates stem cell engraftment and survival in the myocardium, using state-of-the-art molecular imaging. We are seeking candidates who are interested in conducting and leading experimental studies that will cross the bridge from cell to rodent animal models. The successful candidate should be independent and creative, ...

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The Vaccine Research Group at Mayo Clinic Rochester seeks a postdoctoral fellow to join a highly successful research team to study the genetics of immune responses to vaccines and research related to Biodefense vaccines. Projects include studies on smallpox, measles, rubella, influenza and other viral vaccines. Requirements for the position include 1) a Ph.D. and/or M.D. degree with significant past laboratory research experience, 2) a keen interest in vaccine and Biodefense research. Individ...

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A postdoctoral position is available to study the neurobiology of alcohol use disorders and addictive behaviors. The successful applicant will investigate adenosine and glutamate signaling in neuron-glial interactions and/or neruobehavioral pharmacology of alcoholism using rodent models. Qualifications for the position include a Ph.D. degree with 0-3 years postdoctoral experience in molecular biology, neurobiology, rodent behaviors, or molecular pharmacology. Candidates who are highly self-mo...

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The Division of Biomedical Statistics and Informatics (BSI) in the Department of Health Sciences Research, Mayo Clinic (http://www.mayo.edu) in Rochester, Minnesota (www.macc-rochester.com) is seeking a bioinformatics Research Associate (RA) with a Ph.D. in bioinformatics or biology/biochemistry with significant bioinformatics experience. The RA in this position will collaborate with Mayo researchers in studies conducted using genomics/proteomics/metabolomics as well as high throughput sequencin...

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A newly funded R01 grant, located at Mayo Clinic Arizona ("Molecular Pathogenesis of Multiple Myeloma") requires a motivated postdoctoral scientist to study the functional consequences of the activation of critical pathways we have identified frequently mutated (e.g., NFKB, histone methylation) in human and murine myeloma. Relevant studies from the Bergsagel lab include Keats et al, Cancer Cell 2007 12(2) 131-44 and Chesi et al, Cancer Cell 2008 13(2) 167-80....

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