Pharmacogenomics - Richard M. Weinshilboum

What is Pharmacogenomics?

Pharmacogenomics is the study of the role of inheritance in variation in drug response phenotypes—phenotypes that can range from life-threatening adverse drug reactions to lack of the desired therapeutic effect of a drug. Reactions involved in the metabolism of drugs are classified as either "phase I" or "phase II".

Phase II drug metabolism includes conjugation reactions, and for over 20 years the Mayo pharmacogenetics research program has contributed to the understanding of biochemical, molecular and genomic basis for inherited variations in phase II pathways of drug metabolism.