Receptor Biology - Steven M. Sine

Fan Gao

Email: gao.fan@mayo.edu

Education

• Ph.D. candidate in Biomedical Engineering Program (2000 - Present)
  Mayo Clinic College of Medicine, Mayo Graduate School
• B.S. in Chemical Physics (2000)
  Univ. of Science & Technology of China

Objective

A PhD candidate with broad interests in structural biology, scientific computing, biochemistry, biophysics and molecular biology with extensive experience in protein homology modeling, prediction of protein-small molecule recognition, protein conformational change and structure-based drug design.

Projects

• Homology modeling of LBD domain of nicotinic acetylcholine receptor and different ligands docking.
• Long MD simulation of acetylcholine binding protein and its conformational change analysis.
• Design of structure-based virtual compound screening platform and potential lead testing.
• Homology modeling of NBD2 domain in the K_ATP channel regulatory SUR2A subunits.

Research experience

• Unix/Linux system, Parallel computing, C Programming, Perl Programming, Python Programming, Matlab
• Application of different software including: QUANTA, INSIGHT II, SYBYL, AMBER7, AUTODOCK3, MODELLER6, JACKAL, AMSOL, MOPAC, GAUSSIAN98, and GROMACS3.
• Basic skills in biochemistry.