WON YONG LEE, D.V.M., M.S.

Email: lee.wonyong@mayo.edu

Education

Mar 1988 - Feb 1992 Major: Veterinary Medicine

School of Veterinary Medicine, Kon-Kuk University Mojin-dong, Kwangjin-ku, Seoul, Korea

Graduate studies 1:

Mar 1992 - Feb 1994 Toxicology Program

School of Veterinary Medicine, Kon-Kuk University, (Master's)

Graduate studies 2:

Jun 1999 - Molecular Neuroscience Program

Mayo Graduate School, Mayo Clinic and Foundation, (Ph.D)

Scholarships: College Fellowship (1988)

Degrees:

Master of Science (M.S.) , Kon-Kuk University (Feb 1994)

Thesis: Studies of Neurotoxicological Alterations Induced by N-butyl benzenesulfonamide in Wistar Rats.

Doctor of Veterinary Medicine (D.V.M.), Kon-Kuk University (Feb 1992)

Licenses:

Doctor of Veterinary Medicine (D.V.M., Mar 1992)

Ministry of Agriculture, Forestry and Fishery, Korea

SCUBA Diver (Jun 1999)

National Association of Underwater Instructors (SD-990564), NAUI Korea

Professional Background:

Apr 1995 - May 1999 Toxicologist and Senior Research Scientist

Dec 1993 - Mar 1995 Toxicologist and Research Scientist

Pharmacology and Toxicology Lab

Central Research Labs, Dong Wha Pharm. Ind. Co., Ltd. Anyang-dong 189, Anyang, Kyunggi-do 430-010, Korea.

Sep 1992-Dec 1993 Research Assistant

Department of Toxicology

*National Institute of Safety Research (NISR)

Nokbundong 5, Eunpyung-ku, Seoul, Korea

*Currently, Toxicological Research Institute, Korea FDA (equivalent to National Center for Toxicological Research (NCTR) of US FDA)

Publications:

Peer reviewed articles

Steven M. Sine, Hai-Long Wang, Kinji Ohno, Xin-Ming Shen, Won Yong Lee, and Andrew G. Engel (2003), Mechanistic diversity underlying fast channel congenital myasthenic syndromes, Annals of the New York Academy of Sciences, 998:128-138.

Steven M. Sine, Xing-Ming Shen, Hai-Long Wang, Kinji Ohno, Won-Yong Lee, Akira Tsujino, Joan Brengmann, Nina Bren, Jiri Vajsar, and Andrew G. Engel (2002), Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating, Journal of General Physiology, 120:483-496.

Won Yong Lee, Eun Yi Moon, Jin Lee, Chung Ha Choi, Soon Chul Nam, Kyung Bae Park, Jei Man Ryu, Yong Ho Chung, Sung June Yoon, Dug Keun Lee (1998), Toxicities of 166Holmium-chitosan in Mice, Arzneimittel-Forschung, 48:300-304.

Sung June Yoon, Yong Ho Chung, Chi Woo Lee, Yoon Seok Oh, Dong Rack Choi, Nam Doo Kim, Jae Kyung Lim, Yoon Ho Jin, Dug Keun Lee, and Won Yong Lee (1997), Synthesis, pharmacokinetics, and biological activity of a series of new pyridonecarboxylic acid antibacterial agents bearing a 5-fluoro-2-pyridyl group or a 3-fluoro-4-pyridyl group at N-1, Journal of Heterocyclic Chemistry, 34:1021-1027.

Won Yong Lee, Jin Lee, Eun Yi Moon, Dug Keun Lee (1997), Acute toxicity of DW-166HC (Holmium-165-chitosan) in mice, Journal of Applied Pharmacology (Korea), 5:100-105.

Won Yong Lee, Se Jin Hwang, Dae Hyun Cho, Jin Suk Kim (1995), Behavioral changes with alterations of choline acetyltransferase immunoreactivities induced by N-butyl benzenesulfonamide, Veterinary and Human Toxicology, 37:537-542.

Dae Hyun Cho, Yong Jeong, Jun Gyou Kim, Bong Hun Lee, Se Jin Hwang, Won Yong Lee, Jeong Goo Kim, Tai Soon Cho, Jin Suk Kim and Hwa Hwey Moon (1995), The neurotoxicological alterations induced by narcotic drugs and industrial chemicals in the rat are associated with quantitative changes in glial fibrillary acidic protein, Korean Journal of Toxicology, 11:315-327.

Dae Hyun Cho, Se Jin Hwang, Won Yong Lee, Byeongwoo Ahn, Kang Chin and Tai Soon Cho (1994), Effects of methamphetamine on motor activities, immunoreactivities of tyrosine hydroxylase and morphological changes of dopaminergic neurons in the rat, Korean Journal of Toxicology, 10:59-71.

Dae Hyun Cho, Se Jin Hwang, Won Yong Lee, Joo Young Lee, Hyung Jung Yoon and Byung Woo Moon (1993), Acute oral toxicity studies of WHS-1 and WHS-2 in rats, Journal of Applied Pharmacology (Korea), 2:275-279.

Dae Hyun Cho, Se Jin Hwang, Won Yong Lee, Joo Young Lee, Hyung Jung Yoon and Byung Woo Moon (1993), Acute subcutaneous toxicity studies of banaron cream in rats, Journal of Applied Pharmacology (Korea), 2:280-283.

Presentation and Posters

Oral presentation:

Nov 26, 1993 (Seoul National University, Seoul, Korea)

* The 3rd Korea-Japan Toxicology Symposium and Conference on Recent Trends in Toxicological

Research and Activities:

Organizer: Korean Society of Toxicology, Korean Environmental Mutagen

Society, and Japanese Society of Toxicological Science

Topic: The Neurotoxicological Alterations Induced by N-butyl Benzenesulfonamide in Wistar rats

Posters:

Won Yong Lee and Steven M. Sine (2002), Network of hydrophobic side chains contribute to agonist binding in the nicotinic acetylcholine receptor. Society for Neuroscience 32nd Annual Meeting (Orlando, FL).

Won Yong Lee, Nina Bren and Steven M. Sine (2002), Contribution of branched hydrophobic side-chains to acetylcholine binding affinity of the muscle nAChR. Biophysical Society 46th Annual Meeting (San Francisco, CA).

Yunha Hwang, Kyungoh Han, Won Yong Lee, Yongho Chung, Sungjune Yoon and Dugkeun Lee (1995), Efficacy of DW-116, A novel synthesized quinolone, for treatment of respiratory tract infection and urinary tract infection, 35th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) (San Francisco, USA), F194 (p. 147), Annual Meeting of the American Society for Microbiology.

Yunha Hwang, Kyungoh Han, Won Yong Lee, Yongho Chung, Sungjune Yoon and Dugkeun Lee (1995), Efficacy of DW-116, A new fluoroquinolone, for therapy of experimental thigh infection, 35th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) (San Francisco, USA), F195 (p. 147), Annual Meeting of the American Society for Microbiology.

Won Yong Lee, Yunha Hwang, Seungkyu Sung, Eunyi Moon, Yongho Chung, Sungjune Yoon and Dugkeun Lee (1995), The pharmacokinetic studies of DW-116, 35th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) (San Francisco, USA), F196 (p. 147), Annual Meeting of the American Society for Microbiology.

Jin Suk Kim, Won Yong Lee, Sang Mok Lee, and Won Chang Lee (1992), The effects of thiamin on fetal growth and development in CD-1 mice exposed with mercury for the gestation period, Proceeding of Korea Society of Toxicology (Korea), P12.

Dae Hyun Cho, Se Jin Hwang, Won Yong Lee, Jung Sik Park and Kang Chin (1992), The neurotoxic effects of single and repeated dose of methamphetamine on tyrosine hydroxylase immuno-reactivity in rat brain, Proceeding of Korea Society of Toxicology (Korea), P16.