Richard J. Caselli, M.D.

My research program focuses on cognitive aging; and the changes that can be detected before the symptomatic onset of memory loss and related symptoms of Alzheimer's disease.

We have capitalized on the discovery of prevalent genetic risk factors (particularly APOE e4) to identify and quantify an individual's risk for developing Alzheimer's disease, and unlike most programs that focus only on elderly cohorts, ours encompassess the entire adult age range.

In addition, I serve as clinical core director of the Alzheimer's Disease Center at Mayo Clinic in Arizona, which focuses more on symptomatic patients with mild cognitive impairment and dementia.

Between these two programs, my research encompasses the entire adult age and symptomatic spectrum from young and healthy to elderly and impaired with our key questions aimed at the transition points and factors that might delay or prevent that transition.

My personal focus is on the neuropsychological and related behavioral changes that can be detected; but through a close series of collaborations, I am also involved in brain imaging (FDG-PET, PIB-PET, MRI), neuropathology, genomics, and epigenetic factors that influence Alzheimer's disease risk and age of onset.