David Dingli, M.D., Ph.D.

Location: Minnesota

Primary Appointment
Hematology
Academic Rank
Professor of Medicine

Summary

The purpose of my research is to develop and optimize the use of replicating viruses for cancer therapy. I am interested in understanding the dynamic interactions between tumors cells, therapeutic viruses and the immune system and how these interactions determine the outcome of therapy. Our approach enables us to develop novel viruses with altered dynamic properties that may lead to better tumor control. The laboratory lives at the interface between theory and experiment. We develop mathematical models to understand the outcomes of in vivo experiments and explore in silico therapeutic scenarios based on validated models. The models generate hypothesis that we utilize to design novel viruses that are then tested experimentally.

We also study clonal evolution in hematopoiesis with special reference to hematopoietic neoplasms. Starting from normal hematopoiesis, we model tumor development and its response to therapy. In addition, we study the evolution of 'benign' clonal disorders such as paroxysmal nocturnal hemoglobinuria and non-malignant processes such as cyclic hematopoiesis and hematopoietic recovery after stem cell transplantation.

Recent publications

See a listing of my publications

Education

Visiting Scientist
Max Planck Institute for Evolutionary Biology, Plon, Germany

Visiting Scientist – Program for Evolutionary Dynamics
Harvard University

Visiting Scientist – Complexo Interdisciplinar, Department of Physics
University of Lisbon

Fellowship
Hematology/Oncology Fellowship Program, Mayo School of Graduate Medical Education, College of Medicine, Mayo Clinic

Ph.D.
Molecular Biology, Biochemistry and Molecular Biology Track, Mayo Graduate School, College of Medicine, Mayo Clinic

Ph.D. – Molecular Biology
Mayo Graduate School, College of Medicine, Mayo Clinic

Residency
Mayo School of Graduate Medical Education, College of Medicine, Mayo Clinic

Senior House Officer
Department of Hematology, West Glasgow University Hospitals, NHS Trust, University of Glasgow, Scotland

Senior House Officer
Department of Internal Medicine, St. Luke's University Hospital, Guardamangia

Internship
St. Luke's University Hospital, Guardamangia

M.D.
University of Malta Medical School, Guardamangia, Malta

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