Lawrence J. Mandarino, Ph.D.

The overriding goal of research in our laboratory is to define the molecular mechanisms responsible for the pathogenesis of insulin resistance in human skeletal muscle. Specifically, research focuses on abnormalities in insulin signaling pathways, particularly related to abnormal patterns of protein phosphorylation, and second, on muscle remodeling and regeneration as it relates to mitochondrial function and fuel utilization.

Techniques combine clinical research using the glucose clamp technique, coupled with muscle biopsies, while analytical techniques range from proteomics-based protein phosphorylation and abundance studies to microarray based studies of gene expression.

Dr. Mandarino currently holds appointments at Mayo Clinic in Arizona and Arizona State University, and directs the ASU/Mayo Center for Metabolic and Vascular Biology.