Researcher Profile: Ackerman, Michael J, M.D., Ph.D.

Michael J. Ackerman, M.D., Ph.D.

Location: Minnesota

Primary Appointment
Cardiovascular Diseases
Joint Appointment
Pediatric Cardiology
Molecular Pharmacology and Experimental Therapeutics
Academic Rank
Professor of Medicine
Professor of Pediatrics
Professor of Pharmacology

Clinical Profile

Summary

Genomics and Genotype-Phenotype Relationships in Heritable Cardiovascular Diseases Predisposing to Sudden Death

In our Sudden Death Genomics Laboratory, research interests include genomics, mutational analysis, and novel gene discovery related to the cardiac channelopathies like long QT syndrome, catecholaminergic polymorphic ventricular tachycardia, and sudden unexplained death including sudden infant death syndrome and inherited sarcomere diseases like hypertrophic cardiomyopathy. In addition, as Director of the Long QT Syndrome Clinic, there are active clinical translational research efforts devoted to identifying individuals at greatest risk for sudden death. These projects include autonomic nervous system studies and overnight sleep studies.

Current studies include:

Genotype-phenotype correlations and novel gene discovery in congenital long QT syndrome
Mutational analysis in catecholaminergic polymorphic ventricular tachycardia
Genotype-phenotype correlations and novel gene discovery in hypertrophic cardiomyopathy
Drownings as a genetic disorder
Cardiac channelopathies in the sudden infant death syndrome (SIDS)
Molecular autopsy of sudden unexplained death in the young
Catecholamine provocation testing in the evaluation of congenital long QT syndrome
Sleep and neuralcirculatory control in long QT syndrome

Recent publications

See my publications on PubMed

Education

Fellowship – Pediatric Cardiology
Mayo Graduate School of Medicine

Post-Doc – Postdoctoral Research - Molecular and Functional Basis of the Inherited Long QT Syndrome. Mentor: Stephen N. Thibodeau, PhD.
Mayo Graduate School of Medicine

Residency – Pediatric And Adolescent Medicine
Mayo Graduate School of Medicine

Ph.D. – Thesis: Molecular and Electrophysical Characterization of the Swelling-Induced Chloride Conductance Pathway in Xenopus Oocytes. Mentor: David E. Clapham, M.D., Ph.D.
Mayo Medical School

M.D.
Mayo Medical School

B.A. – Chemistry and Mathematics
Luther College

Areas of Research
Windland Smith Rice Sudden Death Genomics Laboratory
Zebrafish Core Facility

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