Researcher Profile: Ansell, Stephen M, M.D., Ph.D.

Stephen M. Ansell, M.D., Ph.D.

Joint Appointment
Hematology
Academic Rank
Associate Professor of Medicine

Summary

B-cell non-Hodgkin's lymphoma involves the neoplastic transformation of B-lymphocytes. In the areas of B-cell lymphoma, however, intratumoral T-lymphocytes are also seen and we have shown that the presence of increased numbers of intratumoral CD4+ T-cells predicts a better clinical outcome. Our lab is currently investigating the phenotype and activity of these intratumoral T-cells and developing strategies to modulate the T-cell infiltration in areas of B-cell lymphoma.

Further areas of research interest include the development of biologic therapies for non-Hodgkin's lymphoma. The current strategies being developed include the use of novel antibodies and cytokines, the use of antisense oligonucleotides, and the development of strategies to inhibit signaling through receptors that promote the survival of malignant B-cells.

The utility of these strategies is being tested in early phase clinical trials. These studies are being conducted within the Division of Hematology at the Mayo Clinic, the Mayo Clinic Cancer Center, and the North Central Cancer Treatment Group.

Recent publications

See my publications on PubMed

Education

Fellowship – Hematology/Oncology
Mayo Medical School

Residency – Internal Medicine
Mayo Medical School

Registrar – Internal Medicine
University of the Witwatersrand, South Africa

Fellowship – Medical Oncology
University of Pretoria, South Africa

Ph.D. – Medical Sciences
University of Pretoria, South Africa

Residency – Internal Medicine
University of Pretoria, South Africa

DTM&H
University of the Witwatersrand, South Africa

Internship – Internal Medicine/Surgery
South Africa

MB ChB – Medicine and Surgery
University of Pretoria, South Africa

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