James D. Hannon, M.D.

Location: Minnesota

Primary Appointment
Anesthesiology
Academic Rank
Assistant Professor of Anesthesiology

Summary

Volatile anesthetic agents are widely used to anesthetize patients during surgery and imaging procedures, but they can have potentially hazardous effects on cardiac performance via calcium homeostasis. In addition, abnormal calcium homeostasis has been implicated in heart failure and cardiac arrhythmias.

We are interested in the basic mechanisms involved in the regulation of contraction in cardiac muscle under normal and pathologic conditions. Currently we are studying the effects of several anesthetics on myocardial contractility and calcium sensitivity using an animal model of right ventricular hypertrophy and heart failure. To accomplish this, we routinely use isolated cardiac muscle and dissociated single myocytes to make measurements of mechanical properties and intracellular ions. Additional projects involve techniques such as cell culture and gene transfer to alter the level expression of various proteins in the heart. Projects are also underway to investigate the mechanisms involved in myocardial preconditioning by intravenous and volatile anesthetics.

Recent publications

See my publications

Education

Residency
Department of Anesthesiology, Mayo Graduate School of Medicine

Chief Resident
Department of Anesthesiology, Mayo Graduate School of Medicine

Research Fellowship
Department of Physiology and Biophysics, University of Washington

Research Fellowship
Department of Pharmacology, Mayo Graduate School, College of Medicine, Mayo Clinic

Residency
Department of Internal Medicine, Mayo Graduate School, College of Medicine, Mayo Clinic

M.D.
Mayo Medical School

B.A. – Chemistry
Columbia University

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