Jin Jen, M.D., Ph.D.
The primary focus of the Jen Laboratory is to study the molecular basis of and identify novel molecular markers for Non-Small Cell Lung Cancer (NSCLC). Taking advantage of the large tissue resources at Mayo, our laboratory focuses on genetic analysis of early age onset and nonsmoker lung cancers. We recently identified a candidate gene that is frequently inactivated in lung cancers via promoter DNA methylation. Functionally, the gene suppresses telomerase expression in vitro and affects telomere length in vivo. We are currently investigating the mechanism of telomerase regulation by this novel gene and its role in lung cancer onset and risk. We are also examining its involvement in lung cancers from non-smokers. Our work on lung cancer from never smokers focuses on examining the genetic alterations and how they affect miRNA expression for to identify lung cancer prognostic markers and therapeutic targets.
In addition, my laboratory has constructed a lung tissue microarray (TMA) containing 300 NSCLC samples and 175 neuroendocrine tumors. We seek to utilize these TMAs and our expertise in this area to evaluate and identify novel protein markers for lung cancer.
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