John C. Lieske, M.D.
The earliest events in kidney stone formation remain poorly understood. It is known that fluid within renal tubules is often supersaturated, favoring the formation of crystals.
However, calculations based on the known rates of tubular fluid flow and crystal growth suggest that newly formed crystals could never become large enough to block an individual tubule lumen. Therefore, crystals that develop in the nephron should be excreted in tubular fluid and kidney stones should not form.
Since many individuals do form stones, other unknown factors must — in certain circumstances — permit retention of crystals in the kidney.
John C. Lieske, M.D., is working to identify those factors that mediate adhesion of crystals to tubule lining cells and understand how subsequent cellular processing of retained crystals results in renal stone formation.
Focus areasSpecific research topics include:
Significance to patient care
Kidney stones cause significant pain, loss of productivity and medical expense. In rarer cases, they can cause kidney damage and kidney failure.
Dr. Lieske's research is identifying underlying causes of kidney stones and improving treatment strategies to prevent these complications.
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