Current Studies:

• Multicentered, Randomized Trial of High-dose URSO in PSC.
• Pilot Study: Therapeutic Effect of Alanine Supplement in Patients with Nonalcoholic Steatohepatitis.
• Open label Pilot Study Evaluating Minocycline in Patients with Primary Sclerosing Cholangitis (PSC).
• Open-label Pilot Study of Moexipril for the Treatment of NASH.
• A Randomized, Placebo-Controlled Trial of Betaine in NASH.
• Open-label Pilot Study of Folic Acid in Patients with Nonalcoholic Fatty Liver Disease.
• A Pilot Study of Combivir Therapy for PBC.

Significance of Research

The research has been important in helping to find therapies for patients with primary biliary cirrhosis, primary sclerosing cholangitis, and nonalcoholic steatohepatitis. One of our studies led to FDA approval for ursodeoxycholic acid for primary biliary cirrhosis.

Research Interests

Optimizing management strategies for patients with primary biliary cirrhosis, primary sclerosing cholangitis, and nonalcoholic steatohepatitis.

Studies evaluating primary therapies as well as management of complications have been ongoing for over a decade

Pilot studies evaluating innovative therapies as well full-scale randomized trials to confirm results from pilot studies are ongoing.