Carlos B. Mantilla, M.D., Ph.D.
Carlos B. Mantilla, M.D., Ph.D. studies the control of breathing in humans. The long-term goal of Dr. Mantilla's research team is to develop rational and effective therapies for the treatment of diseases that impair the ability to breathe effectively and their associated complications.
Dr. Mantilla's team makes extensive use of cutting-edge and state-of-the-art techniques to evaluate the function of motor neurons and muscle fibers that include multi-color, 3-D confocal imaging, laser capture microdissection and quantitative transcriptional analyses in single cells, high-fidelity electrophysiological recordings and mathematical models of motor control.
Dr. Mantilla and his team also use whole-body plethysmography, lung mechanics and wireless telemetry of respiratory function to assess the impact of physiologic changes in motor neurons, muscle fibers and neuromuscular junctions in diseases and conditions that limit the ability to sustain breathing and perform expulsive maneuvers such as coughing and sneezing that are necessary to maintain airways clear.
Dr. Mantilla's research has been funded by the National Institutes of Health and the Paralyzed Veterans of America Research Foundation, among other organizations.
Significance to patient care
Dr. Mantilla's research into the control of breathing will help prevent and improve quality-of-life for patients across the full spectrum of age, as well as those with spinal cord injury and neuromuscular disorders.
Anesthesiology & Pain Management
Preliminary Internal Medicine
© 2013 Mayo Foundation for Medical Education and Research. All rights reserved.