Dr. McCollough's research interests revolve around the technology of CT imaging, and its many clinical applications. Recent work has focused on state of the art multi-slice CT imaging of the heart. As Director of the multi-disciplinary CT Clinical Innovation Center, she is working with numerous co-investogators on projects seeking to detect and /or quantify disease using CT imaging. These projects include perfusion imaging of the heart, brain and abdominal organs, measurement of aortic distensibility or vessel pulsation, isotropic resolution imaging of sub-mm structures in the inner ear, and renal stone composition analysis. Dr. McCollough is active in numerous national and international organizations in the areas of CT imaging and radiation dose assessment and reduction. She is additionally focused on the implementation of automated exposure control systems for CT which appropriately increase or decrease radation dose based on individual body characteristics, thus optimizing image quality and dose on a patient by patient basis. She remains active in the field of CT performance testing and accreditation.