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Publications - Philippe R . Housmans, M.D., Ph.D.

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  1. Hannon JD, Housmans PR. Ca2+: is there something new for the cardiovascular anesthesiologist? Curr Opin Anaesthesiol 2009 Feb; 22(1):114-20.
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  2. Hannon JD, Housmans PR. Ca2+: is there something new for the cardiovascular anesthesiologist? Current Opinion in Anesthesiology 2009; 22(1):114-120.
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  3. Breukelmann D, Housmans PR. Halothane, isoflurane, and sevoflurane increase the kinetics of Ca2+-induced conformational change of recombinant human cardiac troponin C. Anesth Analg 2007 Feb; 104(2):332-7.
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  4. Hannon JD, Cody MJ, Sun DX, Housmans PR. Effects of isoflurane and sevoflurane on intracellular calcium and contractility in pressure-overload hypertrophy. Anesthesiology 2004 Sep; 101(3):675-86.
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  5. Breukelmann D, Housmans PR. Equilibrium titration of protein-ligand binding affinity in the presence of volatile reagents: A semiautomated approach. Anal Biochem 2003 Feb 1; 313(1):86-8.
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  6. Bartunek AE, Claes VA, Housmans PR. Effects of volatile anesthetics on elastic stiffness in isometrically contracting ferret ventricular myocardium. J Appl Physiol 2002 Jun; 92(6):2491-500.
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  7. Lang R, Gomes AV, Zhao JJ, Housmans PR, Miller T, Potter JD. Functional analysis of a troponin I (R145G) mutation associated with familial hypertrophic cardiomyopathy. J Biol Chem 2002 Apr 5; 277(14):11670-8.
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  8. Bartunek AE, Claes VA, Housmans PR. Effects of volatile anesthetics on stiffness of mammalian ventricular muscle. J Appl Physiol 2001 Oct; 91(4):1563-73.
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  9. Housmans PR, Bartunek AE. Effects of volatile anesthetics on ryanodine-treated ferret cardiac muscle. J Cardiovasc Pharmacol 2001 Aug; 38(2):211-8.
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  10. Hart CY, Meyer DM, Tazelaar HD, Grande JP, Burnett JC Jr, Housmans PR, Redfield MM. Load versus humoral activation in the genesis of early hypertensive heart disease. Circulation 2001 Jul 10; 104(2):215-20.
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  11. Hannon JD, Cody MJ, Housmans PR. Effects of isoflurane on intracellular calcium and myocardial crossbridge kinetics in tetanized papillary muscles. Anesthesiology 2001 May; 94(5):856-61.
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  12. Knollmann BC, Blatt SA, Horton K, de Freitas F, Miller T, Bell M, Housmans PR, Weissman NJ, Morad M, Potter JD. Inotropic stimulation induces cardiac dysfunction in transgenic mice expressing a troponin T (I79N) mutation linked to familial hypertrophic cardiomyopathy. J Biol Chem 2001 Mar 30; 276(13):10039-48.
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  13. Hernandez OM, Housmans PR, Potter JD. Plasticity in skeletal cardiac, and smooth muscle - invited review: pathophysiology of cardiac muscle contraction and relaxation as a result of alterations in thin filament regulation. J Appl Physiol 2001 Mar; 90(3):1125-36.
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  14. Miller T, Szczesna D, Housmans PR, Zhao JJ, de Freitas F, Gomes AV, Culbreath L, McCue J, Wang Y, Xu YY, Glenn W, Kerrick L, Potter JD. Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation. J Biol Chem 2001 Feb 9; 276(6):3743-3755.
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  15. Bartunek AE, Housmans PR. Effects of sevoflurane on the intracellular Ca2+ transient in ferret cardiac muscle. Anesthesiology 2000 Dec; 93(6):1500-8.
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  16. Bartunek AE, Housmans PR. Effects of sevoflurane on the contractility of ferret ventricular myocardium. J Appl Physiol 2000 Nov; 89(5):1778-86.
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  17. Housmans PR, Wanek LA. Effects of halothane, enflurane, and isoflurane on measurements of Ca2+ by calcium electrode and aequorin luminescence. Anal Biochem 2000 Aug 15; 284(1):60-64.
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  18. Housmans PR, Wanek LA, Carton EG, Bartunek AE. Effects of halothane and isoflurane on the intracellular Ca2+ transient in ferret cardiac muscle. Anesthesiology 2000 Jul; 93(1):189-201.
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  19. Prakash YS, Cody MJ, Hannon JD, Housmans PR, Sieck GC. Comparison of volatile anesthetic effects on actin-myosin cross-bridge cycling in neonatal versus adult cardiac muscle. Anesthesiology 2000 Apr; 92(4):1114-25.
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  20. Prakash YS, Cody MJ, Housmans PR, Hannon JD, Sieck GC. Comparison of cross-bridge cycling kinetics in neonatal vs. adult rat ventricular muscle. J Muscle Res Cell Motil 1999 Oct; 20(7):717-23.
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  21. Pan BS, Hannon JD, Wiedmann R, Potter JD, Kranias EG, Shen YT, Johnson RG Jr, Housmans PR. Effects of isoproterenol on twitch contraction of wild type and phospholamban-deficient murine ventricular myocardium. J Mol Cell Cardiol 1999 Jan; 31(1):159-66.
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  22. De Witte J, Deloof T, De Veylder J, Housmans PR. Tramadol in the treatment of postanesthetic shivering. Acta Anaesthesiol Scand 1997; 41:506-10.
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  23. Housmans PR, Rietman GW, Wellens F, Verbeke J, Nollet G. Ventricular dysrhythmia in the native heart after heterotopic heart transplantation: diagnosis with selective electrocardiography. Anesthesiology 1996 Oct; 85(4):936-9.
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  24. Housmans PR, Kudsioglu ST, Bingham J. Mechanism of the negative inotropic effect of thiopental in isolated ferret ventricular myocardium. Anesthesiology 1995 Feb; 82(2):436-50.
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  25. Cook DJ, Housmans PR. Mechanism of the negative inotropic effect of propofol in isolated ferret ventricular myocardium. Anesthesiology 1994 Apr; 80(4):859-71.
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  26. Mattheussen M, Housmans PR. Mechanism of the direct, negative inotropic effect of etomidate in isolated ferret ventricular myocardium. Anesthesiology 1993 Dec; 79(6):1284-95.
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  27. Kongsayreepong S, Cook DJ, Housmans PR. Mechanism of the direct, negative intotropic effect of ketamine in isolated ferret and frog ventricular myocardium. Anesthesiology 1993 Aug; 79:313-22.
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  28. Jones KA, Housmans PR, Warner DO, Lorenz RR, Rehder K. Halothane alters cytosolic calcium transient in tracheal smooth muscle. Am J Physiol 1993 Jul; 265(1 Pt 1):L80-6.
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  29. Cook DJ, Housmans PR, Rorie DK. Effect of ketamine HCl on norepinephrine disposition in isolated ferret ventricular myocardium. J Pharmacol Exp Ther 1992 Apr; 261(1):101-7.
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  30. Carton EG, Housmans PR. Role of transsarcolemmal Ca2+ entry in the negative inotropic effect of nitrous oxide in isolated ferret myocardium. Anesth Analg 1992 Apr; 74(4):575-9.
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  31. Cook DJ, Carton EG, Housmans PR. Mechanism of the positive inotropic effect of ketamine in isolated ferret ventricular papillary muscle. Anesthesiology 1991 May; 74(5):880-8.
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  32. Carton EG, Wanek LA, Housmans PR. Effects of nitrous oxide on contractility, relaxation and the intracellular calcium transient of isolated mammalian ventricular myocardium. J Pharmacol Exp Ther 1991 May; 257(2):843-9.
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  33. Baele P, Housmans PR. The effects of halothane, enflurane, and isoflurane on the length-tension relation of the isolated ventricular papillary muscle of the ferret. Anesthesiology 1991 Feb; 74(2):281-91.
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  34. Housmans PR. Effects of dexmedetomidine on contractility, relaxation, and intracellular calcium transients of isolated ventricular myocardium. Anesthesiology 1990 Nov; 73(5):919-22.
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  35. Housmans PR. Negative inotropy of halogenated anesthetics in ferret ventricular myocardium. Am J Physiol 1990 Sep; 259(3 Pt 2):H827-34.
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  36. Nishimura RA, Abel MD, Hatle LK, Holmes DR Jr, Housmans PR, Ritman EL, Tajik AJ. Significance of Doppler indices of diastolic filling of the left ventricle: comparison with invasive hemodynamics in a canine model. Am Heart J 1989 Dec; 118(6):1248-58.
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  37. Nishimura RA, Abel MD, Housmans PR, Warnes CA, Tajik AJ. Mitral flow velocity curves as a function of different loading conditions: evaluation by intraoperative transesophageal Doppler echocardiography. J Am Soc Echocardiogr 1989 Mar-Apr; 2(2):79-87.
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  38. Nishimura RA, Housmans PR, Hatle LK, Tajik AJ. Assessment of diastolic function of the heart: background and current applications of Doppler echocardiography. Part I. Physiologic and pathophysiologic features. Mayo Clin Proc 1989 Jan; 64(1):71-81.
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  39. Housmans PR, Murat I. Comparative effects of halothane, enflurane, and isoflurane at equipotent anesthetic concentrations on isolated ventricular myocardium of the ferret. I. Contractility. Anesthesiology 1988 Oct; 69(4):451-63.
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  40. Housmans PR, Murat I. Comparative effects of halothane, enflurane, and isoflurane at equipotent anesthetic concentrations on isolated ventricular myocardium of the ferret. II. Relaxation. Anesthesiology 1988 Oct; 69(4):464-71.
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  41. Murat I, Housmans PR. Minimum alveolar concentrations (MAC) of halothane, enflurane, and isoflurane in ferrets. Anesthesiology 1988 May; 68(5):783-6.
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  42. Brutsaert DL, Rademakers FE, Sys SU, Gillebert TC, Housmans PR. Analysis of relaxation in the evaluation of ventricular function of the heart. Prog Cardiovasc Dis 1985 Sep-Oct; 28(2):143-63.
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  43. Sys SU, Housmans PR, Van Ocken ER, Brutsaert DL. Mechanisms of hypoxia-induced decrease of load dependence of relaxation in cat papillary muscle. Pflugers Arch 1984 Aug; 401(4):368-73.
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  44. Brutsaert DL, Rademakers FE, Sys SU, Gillebert TC, Housmans PR. The heart as an integrated muscle and pump system: triple control and subdivision of cardiac cycle. Acta Cardiol 1984; 39:89-95.
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  45. Housmans PR, Lee NK, Blinks JR. Active shortening retards the decline of the intracellular calcium transient in mammalian heart muscle. Science 1983 Jul 8; 221(4606):159-61.
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  46. Brutsaert DL, De Clerck NM, Housmans PR, Van Ocken ER. Effects of AR-L 115 on contraction and relaxation of isolated mammalian cardiac muscle. J Cardiovasc Pharmacol 1982 May-Jun; 4(3):333-43.
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  47. Goethals MA, Housmans PR, Brutsaert DL. Loading determinants of relaxation in cat papillary muscle. Am J Physiol 1982 Mar; 242(3):H303-9.
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  48. Brutsaert DL, Housmans PR, Goethals MA. Dual control of relaxation. Its role in the ventricular function in the mammalian heart. Circ Res 1980 Nov; 47(5):637-52.
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  49. Lewis MJ, Housmans PR, Claes VA, Brutsaert DL, Henderson AH. Myocardial stiffness during hypoxic and reoxygenation contracture. Cardiovasc Res 1980 Jun; 14(6):339-44.
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  50. Goethals MA, Housmans PR, Brutsaert DL. Load-dependence of physiologically relaxing cardiac muscle. Eur Heart J 1980; (Suppl A):81-7.
  51. Housmans PR, Goethals MA, Brutsaert DL. Double controle de la relaxation du coeur. Arch Mal Coeur Vaiss 1980; 73:609-616.
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  52. Lecarpentier YC, Chuck LH, Housmans PR, De Clerck NM, Brutsaert DL. Nature of load dependence of relaxation in cardiac muscle. Am J Physiol 1979 Oct; 237(4):H455-60.
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  53. Brutsaert DL, de Clerck NM, Goethals MA, Housmans PR. Relaxation of ventricular cardiac muscle. J Physiol (Lond) 1978 Oct; 283:469-80.
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  54. Brutsaert DL, De Clerck NM, Goethals MA, Housmans PR. Mechanisms of relaxation in the heart as a muscle and pump. Eur J Cardiol 1978 Jun; 7(Suppl):71-8.
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  55. Brutsaert DL, Housmans PR. Load clamp analysis of maximal force potential of mammalian cardiac muscle. J Physiol (Lond) 1977 Oct; 271(3):587-603.
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  56. Housmans PR, Brutsaert DL. Three-step yielding of load-clamped mammalian cardiac muscle. Nature 1976 Jul 1; 262(5563):56-8.
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  57. Housmans PR, Brutsaert DL. Length transients in load clamped cat papillary muscle. Arch Int Physiol Biochim 1976; 84(3):568-9.
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