Publications - Philippe R. Housmans, M.D., Ph.D.

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1. Hannon JD, Housmans PR. Ca2+: is there something new for the cardiovascular anesthesiologist? Curr Opin Anaesthesiol. 2009 Feb; 22(1):114-20.
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2. Breukelmann D, Housmans PR. Halothane, isoflurane, and sevoflurane increase the kinetics of Ca2+-induced conformational change of recombinant human cardiac troponin C. Anesth Analg. 2007 Feb; 104(2):332-7.
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3. Hannon JD, Cody MJ, Sun DX, Housmans PR. Effects of isoflurane and sevoflurane on intracellular calcium and contractility in pressure-overload hypertrophy. Anesthesiology. 2004 Sep; 101(3):675-86.
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4. Breukelmann D, Housmans PR. Equilibrium titration of protein-ligand binding affinity in the presence of volatile reagents: A semiautomated approach. Anal Biochem. 2003 Feb 1; 313(1):86-8.
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5. Bartunek AE, Claes VA, Housmans PR. Effects of volatile anesthetics on elastic stiffness in isometrically contracting ferret ventricular myocardium. J Appl Physiol. 2002 Jun; 92(6):2491-500.
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6. Lang R, Gomes AV, Zhao JJ, Housmans PR, Miller T, Potter JD. Functional analysis of a troponin I (R145G) mutation associated with familial hypertrophic cardiomyopathy. J Biol Chem. 2002 Apr 5; 277(14):11670-8.
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7. Bartunek AE, Claes VA, Housmans PR. Effects of volatile anesthetics on stiffness of mammalian ventricular muscle. J Appl Physiol. 2001 Oct; 91(4):1563-73.
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8. Housmans PR, Bartunek AE. Effects of volatile anesthetics on ryanodine-treated ferret cardiac muscle. J Cardiovasc Pharmacol. 2001 Aug; 38(2):211-8.
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9. Hart CY, Meyer DM, Tazelaar HD, Grande JP, Burnett JC Jr, Housmans PR, Redfield MM. Load versus humoral activation in the genesis of early hypertensive heart disease. Circulation. 2001 Jul 10; 104(2):215-20.
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10. Hannon JD, Cody MJ, Housmans PR. Effects of isoflurane on intracellular calcium and myocardial crossbridge kinetics in tetanized papillary muscles. Anesthesiology. 2001 May; 94(5):856-61.
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11. Knollmann BC, Blatt SA, Horton K, de Freitas F, Miller T, Bell M, Housmans PR, Weissman NJ, Morad M, Potter JD. Inotropic stimulation induces cardiac dysfunction in transgenic mice expressing a troponin T (I79N) mutation linked to familial hypertrophic cardiomyopathy. J Biol Chem. 2001 Mar 30; 276(13):10039-48.
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12. Hernandez OM, Housmans PR, Potter JD. Invited Review: pathophysiology of cardiac muscle contraction and relaxation as a result of alterations in thin filament regulation. J Appl Physiol. 2001 Mar; 90(3):1125-36.
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13. Miller T, Szczesna D, Housmans PR, Zhao J, de Freitas F, Gomes AV, Culbreath L, McCue J, Wang Y, Xu Y, Kerrick WG, Potter JD. Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation. J Biol Chem. 2001 Feb 9; 276(6):3743-55. Epub 2000 Nov 01.
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14. Bartunek AE, Housmans PR. Effects of sevoflurane on the intracellular Ca2+ transient in ferret cardiac muscle. Anesthesiology. 2000 Dec; 93(6):1500-8.
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15. Bartunek AE, Housmans PR. Effects of sevoflurane on the contractility of ferret ventricular myocardium. J Appl Physiol. 2000 Nov; 89(5):1778-86.
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16. Housmans PR, Wanek LA. Effects of halothane, enflurane, and isoflurane on measurements of Ca2+ by calcium electrode and aequorin luminescence. Anal Biochem. 2000 Aug 15; 284(1):60-64.
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17. Housmans PR, Wanek LA, Carton EG, Bartunek AE. Effects of halothane and isoflurane on the intracellular Ca2+ transient in ferret cardiac muscle. Anesthesiology. 2000 Jul; 93(1):189-201.
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18. Prakash YS, Cody MJ, Hannon JD, Housmans PR, Sieck GC. Comparison of volatile anesthetic effects on actin-myosin cross-bridge cycling in neonatal versus adult cardiac muscle. Anesthesiology. 2000 Apr; 92(4):1114-25.
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19. Prakash YS, Cody MJ, Housmans PR, Hannon JD, Sieck GC. Comparison of cross-bridge cycling kinetics in neonatal vs. adult rat ventricular muscle. J Muscle Res Cell Motil. 1999 Oct; 20(7):717-23.
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20. Pan BS, Hannon JD, Wiedmann R, Potter JD, Kranias EG, Shen YT, Johnson RG Jr, Housmans PR. Effects of isoproterenol on twitch contraction of wild type and phospholamban-deficient murine ventricular myocardium. J Mol Cell Cardiol. 1999 Jan; 31(1):159-66.
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21. De Witte J, Deloof T, De Veylder J, Housmans PR. Tramadol in the treatment of postanesthetic shivering. Acta Anaesthesiol Scand. 1997; 41:506-10.
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22. Housmans PR, Rietman GW, Wellens F, Verbeke J, Nollet G. Ventricular dysrhythmia in the native heart after heterotopic heart transplantation: diagnosis with selective electrocardiography. Anesthesiology. 1996 Oct; 85(4):936-9.
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23. Housmans PR, Kudsioglu ST, Bingham J. Mechanism of the negative inotropic effect of thiopental in isolated ferret ventricular myocardium. Anesthesiology. 1995 Feb; 82(2):436-50.
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24. Cook DJ, Housmans PR. Mechanism of the negative inotropic effect of propofol in isolated ferret ventricular myocardium. Anesthesiology. 1994 Apr; 80(4):859-71.
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25. Mattheussen M, Housmans PR. Mechanism of the direct, negative inotropic effect of etomidate in isolated ferret ventricular myocardium. Anesthesiology. 1993 Dec; 79(6):1284-95.
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26. Kongsayreepong S, Cook DJ, Housmans PR. Mechanism of the direct, negative intotropic effect of ketamine in isolated ferret and frog ventricular myocardium. Anesthesiology. 1993 Aug; 79:313-22.
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27. Jones KA, Housmans PR, Warner DO, Lorenz RR, Rehder K. Halothane alters cytosolic calcium transient in tracheal smooth muscle. Am J Physiol. 1993 Jul; 265(1 Pt 1):L80-6.
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28. Cook DJ, Housmans PR, Rorie DK. Effect of ketamine HCl on norepinephrine disposition in isolated ferret ventricular myocardium. J Pharmacol Exp Ther. 1992 Apr; 261(1):101-7.
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29. Carton EG, Housmans PR. Role of transsarcolemmal Ca2+ entry in the negative inotropic effect of nitrous oxide in isolated ferret myocardium. Anesth Analg. 1992 Apr; 74(4):575-9.
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30. Cook DJ, Carton EG, Housmans PR. Mechanism of the positive inotropic effect of ketamine in isolated ferret ventricular papillary muscle. Anesthesiology. 1991 May; 74(5):880-8.
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31. Carton EG, Wanek LA, Housmans PR. Effects of nitrous oxide on contractility, relaxation and the intracellular calcium transient of isolated mammalian ventricular myocardium. J Pharmacol Exp Ther. 1991 May; 257(2):843-9.
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32. Baele P, Housmans PR. The effects of halothane, enflurane, and isoflurane on the length-tension relation of the isolated ventricular papillary muscle of the ferret. Anesthesiology. 1991 Feb; 74(2):281-91.
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33. Housmans PR. Effects of dexmedetomidine on contractility, relaxation, and intracellular calcium transients of isolated ventricular myocardium. Anesthesiology. 1990 Nov; 73(5):919-22.
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34. Housmans PR. Negative inotropy of halogenated anesthetics in ferret ventricular myocardium. Am J Physiol. 1990 Sep; 259(3 Pt 2):H827-34.
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35. Nishimura RA, Abel MD, Hatle LK, Holmes DR Jr, Housmans PR, Ritman EL, Tajik AJ. Significance of Doppler indices of diastolic filling of the left ventricle: comparison with invasive hemodynamics in a canine model. Am Heart J. 1989 Dec; 118(6):1248-58.
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36. Nishimura RA, Abel MD, Housmans PR, Warnes CA, Tajik AJ. Mitral flow velocity curves as a function of different loading conditions: evaluation by intraoperative transesophageal Doppler echocardiography. J Am Soc Echocardiogr. 1989 Mar-Apr; 2(2):79-87.
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37. Nishimura RA, Housmans PR, Hatle LK, Tajik AJ. Assessment of diastolic function of the heart: background and current applications of Doppler echocardiography. Part I. Physiologic and pathophysiologic features. Mayo Clin Proc. 1989 Jan; 64(1):71-81.
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