Publications - Peter C. O Brien, Ph.D.

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  1. Dyck PJ, Albers JW, Andersen H, Arezzo JC, Biessels GJ, Bril V, Feldman EL, Litchy WJ, O'Brien PC, Russell JW, on behalf of the Toronto Expert Panel on Diabetic Neuropathy*. Diabetic Polyneuropathies: Update on Research Definition, Diagnostic Criteria and Estimation of Severity. Diabetes Metab Res Rev. 2011 Jun 21. [Epub ahead of print]
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  2. Jayasinghe Y, Cha R, Horn-Ommen J, O'Brien P, Simmons PS. Establishment of normative data for the amount of breast tissue present in healthy children up to two years of age. J Pediatr Adolesc Gynecol. 2010 Oct; 23(5):305-11. Epub 2010 May 21.
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  3. Hennekens CH, Hebert PR, Schneider WR, O'Brien P, Demets D, Borer JS. Academic perspectives on the United States Food and Drug Administration's guidance for industry on diabetes mellitus. Contemp Clin Trials. 2010 Sep; 31(5):411-3. Epub 2010 Jun 19.
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  4. Dyck PJ, Overland CJ, Low PA, Litchy WJ, Davies JL, Dyck PJ, O'Brien PC, Cl vs. NPhys Trial Investigators, Albers JW, Andersen H, Bolton CF, England JD, Klein CJ, Llewelyn JG, Mauermann ML, Russell JW, Singer W, Smith AG, Tesfaye S, Vella A. Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: Cl vs. NPhys trial. Muscle Nerve. 2010 Aug; 42(2):157-64.
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  5. Srinivasan M, Irving BA, Frye RL, O'Brien P, Hartman SJ, McConnell JP, Nair KS. Effects on lipoprotein particles of long-term dehydroepiandrosterone in elderly men and women and testosterone in elderly men. J Clin Endocrinol Metab. 2010 Apr; 95(4):1617-25. Epub 2010 Feb 05.
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  6. Karakelides H, Irving BA, Short KR, O'Brien P, Nair KS. Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function. Diabetes. 2010 Jan; 59(1):89-97. Epub 2009 Oct 15.
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  7. Mundi MS, Karpyak MV, Koutsari C, Votruba SB, O'Brien PC, Jensen MD. Body fat distribution, adipocyte size, and metabolic characteristics of nondiabetic adults. J Clin Endocrinol Metab. 2010 Jan; 95(1):67-73. Epub 2009 Nov 04.
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  8. Koutsari C, Ali AH, Nair KS, Rizza RA, O'Brien P, Khosla S, Jensen MD. Fatty acid metabolism in the elderly: effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women. J Clin Endocrinol Metab. 2009 Sep; 94(9):3414-23. Epub 2009 Jun 30.
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  9. Kantarci K, Weigand SD, Przybelski SA, Shiung MM, Whitwell JL, Negash S, Knopman DS, Boeve BF, O'Brien PC, Petersen RC, Jack CR Jr. Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS. Neurology. 2009 Apr 28; 72(17):1519-25.
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  10. Henderson GC, Dhatariya K, Ford GC, Klaus KA, Basu R, Rizza RA, Jensen MD, Khosla S, O'Brien P, Nair KS. Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements. FASEB J. 2009 Feb; 23(2):631-41. Epub 2008 Sep 30.
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  11. Huang P, Woolson RF, O'Brien PC. A rank-based sample size method for multiple outcomes in clinical trials. Stat Med. 2008 Jul 20; 27(16):3084-104.
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  12. Jack CR Jr, Weigand SD, Shiung MM, Przybelski SA, O'Brien PC, Gunter JL, Knopman DS, Boeve BF, Smith GE, Petersen RC. Atrophy rates accelerate in amnestic mild cognitive impairment. Neurology. 2008 May 6; 70(19 Pt 2):1740-52. Epub 2007 Nov 21.
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  13. O'Brien PC. Discussion on "Second-Guessing Clinical Trial Designs" by Jonathan J Shuster and Myron N Chang. Sequential Analysis. 2008; 27:26-9.
  14. Huang P, Woolsen AF, O'Brien PC. A rank-based sample size method for multiple outcomes in clinical trials. Statistics in Medicine. 2007 Oct.
  15. Dyck PJ, Norell JE, Tritschler H, Schuette K, Samigullin R, Ziegler D, Bastyr EJ 3rd, Litchy WJ, O'Brien PC. Challenges in design of multicenter trials: end points assessed longitudinally for change and monotonicity. Diabetes Care. 2007 Oct; 30(10):2619-25. Epub 2007 May 18
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  16. Kantarci K, Weigand SD, Petersen RC, Boeve BF, Knopman DS, Gunter J, Reyes D, Shiung M, O'Brien PC, Smith GE, Ivnik RJ, Tangalos EG, Jack CR Jr. Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Neurobiol Aging. 2007 Sep; 28(9):1330-9. Epub 2006 Jul 24.
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  17. Service FJ, O'Brien PC. Influence of glycemic variables on hemoglobin A1c. Endocr Pract. 2007 Jul-Aug; 13(4):350-4.
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  18. Gandhi GY, Nuttall GA, Abel MD, Mullany CJ, Schaff HV, O'Brien PC, Johnson MG, Williams AR, Cutshall SM, Mundy LM, Rizza RA, McMahon MM. Intensive intraoperative insulin therapy versus conventional glucose management during cardiac surgery: a randomized trial. Ann Intern Med. 2007 Feb 20; 146(4):233-43.
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  19. Leibson CL, Long KH, Maraganore DM, Bower JH, Ransom JE, O'Brien PC, Rocca WA. Direct medical costs associated with Parkinson's disease: a population-based study. Mov Disord. 2006 Nov; 21(11):1864-71.
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  20. Nair KS, Rizza RA, O'Brien P, Dhatariya K, Short KR, Nehra A, Vittone JL, Klee GG, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall DJ, Melton LJ 3rd, Smith GE, Khosla S, Jensen MD. DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med. 2006 Oct 19; 355(16):1647-59.
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  21. Dyck PJ, Davies JL, Clark VM, Litchy WJ, Dyck PJ, Klein CJ, Rizza RA, Pach JM, Klein R, Larson TS, Melton LJ 3rd, O'Brien PC. Modeling chronic glycemic exposure variables as correlates and predictors of microvascular complications of diabetes. Diabetes Care. 2006 Oct; 29(10):2282-8.
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  22. Singer W, Sandroni P, Opfer-Gehrking TL, Suarez GA, Klein CM, Hines S, O'Brien PC, Slezak J, Low PA. Pyridostigmine treatment trial in neurogenic orthostatic hypotension. Arch Neurol. 2006 Apr; 63(4):513-8. Epub 2006 Feb 13.
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  23. Leibson CL, Maraganore DM, Bower JH, Ransom JE, O'brien PC, Rocca WA. Comorbid conditions associated with Parkinson's disease: a population-based study. Mov Disord. 2006 Apr; 21(4):446-55.
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  24. Jack CR Jr, Shiung MM, Weigand SD, O'Brien PC, Gunter JL, Boeve BF, Knopman DS, Smith GE, Ivnik RJ, Tangalos EG, Petersen RC. Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI. Neurology. 2005 Oct 25; 65(8):1227-31.
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  25. Dyck PJ, O'Brien PC, Litchy WJ, Harper CM, Klein CJ, Dyck PJ. Monotonicity of nerve tests in diabetes: subclinical nerve dysfunction precedes diagnosis of polyneuropathy. Diabetes Care. 2005 Sep; 28(9):2192-200.
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  26. Service FJ, O'Brien PC. Increasing serum betahydroxybutyrate concentrations during the 72-hour fast: evidence against hyperinsulinemic hypoglycemia. J Clin Endocrinol Metab. 2005 Aug; 90(8):4555-8.
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  27. Wingerchuk DM, Benarroch EE, O'Brien PC, Keegan BM, Lucchinetti CF, Noseworthy JH, Weinshenker BG, Rodriguez M. A randomized controlled crossover trial of aspirin for fatigue in multiple sclerosis. Neurology. 2005 Apr 12; 64(7):1267-9.
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  28. Kantarci K, Petersen RC, Boeve BF, Knopman DS, Weigand SD, O'Brien PC, Shiung MM, Smith GE, Ivnik RJ, Tangalos EG, Jack CR Jr. DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment. Neurology. 2005 Mar 8; 64(5):902-4.
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  29. O'Brien PC, Zhang D, Bailey KR. Semi-parametric and non-parametric methods for clinical trials with incomplete data. Stat Med. 2005 Feb 15; 24(3):341-58.
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  30. Suarez GA, Clark VM, Norell JE, Kottke TE, Callahan MJ, O'Brien PC, Low PA, Dyck PJ. Sudden cardiac death in diabetes mellitus: risk factors in the Rochester diabetic neuropathy study. J Neurol Neurosurg Psychiatry. 2005 Feb; 76(2):240-5.
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  31. Low PA, Benrud-Larson LM, Sletten DM, Opfer-Gehrking TL, Weigand SD, O'Brien PC, Suarez GA, Dyck PJ. Autonomic symptoms and diabetic neuropathy - A population-based study. Diabetes Care. 2004 Dec; 27(12):2942-7.
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  32. Lawn ND, Bamlet WR, Radhakrishnan K, O'Brien PC, So EL. Injuries due to seizures in persons with epilepsy - A population-based study. Neurology. 2004 Nov 9; 63(9):1565-70.
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  33. Kantarci K, Petersen RC, Boeve BF, Knopman DS, Tang-Wai DF, O'Brien PC, Weigand SD, Edland SD, Smith GE, Ivnik RJ, Ferman TJ, Tangalos EG, Jack CR Jr. 1H MR spectroscopy in common dementias. Neurology. 2004 Oct 26; 63(8):1393-8.
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  34. Kantarci K, Petersen RC, Boeve BF, Knopman DS, Tang-Wai DF, O'Brien PC, Weigand SD, Edland SD, Smith GE, Ivnik RJ, Ferman TJ, Tangalos EG, Jack CR. H-1 MR spectroscopy in common dementias. Neurology. 2004 Oct 26; 63(8):1393-8.
  35. Windebank AJ, Sorenson EJ, Civil R, O'Brien PC. Role of insulin-like growth factor-I in the treatment of painful small fiber predominant neuropathy. J Peripher Nerv Syst. 2004 Sep; 9(3):183-9.
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  36. Buskirk SJ, Pinkstaff DM, Petrou SP, Wehle MJ, Broderick GA, Young PR, Weigand SD, O'Brien PC, Igel TC. Acute urinary retention after transperineal template-guided prostate biopsy. Int J Radiat Oncol Biol Phys. 2004 Aug 1; 59(5):1360-6.
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  37. Jack CR Jr, Shiung MM, Gunter JL, O'Brien PC, Weigand SD, Knopman DS, Boeve BF, Ivnik RJ, Smith GE, Cha RH, Tangalos EG, Petersen RC. Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD. Neurology. 2004 Feb 24; 62(4):591-600.
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  38. Janson J, Laedtke T, Parisi JE, O'Brien P, Petersen RC, Butler PC. Increased risk of type 2 diabetes in Alzheimer disease. Diabetes. 2004 Feb; 53(2):474-81.
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  39. Karrison TG, O'Brien PC. A rank-sum-type test for paired data with multiple endpoints. J Applied Stat. 2004; 31:1-10.
  40. Meschia JF, Lojacono MA, Miller MJ, Brott TG, Atkinson EJ, O'Brien PC. Reliability of the questionnaire for verifying stroke-free status. Cerebrovasc Dis. 2004; 17(2-3):218-23. Epub 2003 Dec 29.
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  41. Machulda MM, Ward HA, Borowski B, Gunter JL, Cha RH, O'Brien PC, Petersen RC, Boeve BF, Knopman D, Tang-Wai DF, Ivnik RJ, Smith GE, Tangalos EG, Jack CR Jr. Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients. Neurology. 2003 Aug 26; 61(4):500-6.
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  42. Meschia JF, Atkinson EJ, O'Brien PC, Brott TG, Brown RD Jr, Hardy J. Familial clustering of stroke according to proband age at onset of presenting ischemic stroke. Stroke. 2003 Jul; 34(7):e89-91. Epub 2003 Jun 19.
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  43. Kornick CA, Santiago-Palma J, Schulman G, O'Brien PC, Weigand S, Payne R, Manfredi PL. A safe and effective method for converting patients from transdermal to intravenous fentanyl for the treatment of acute cancer-related pain. Cancer. 2003 Jun 15; 97(12):3121-4.
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  44. Nielsen S, Guo Z, Albu JB, Klein S, O'Brien PC, Jensen MD. Energy expenditure, sex, and endogenous fuel availability in humans. J Clin Invest. 2003 Apr; 111(7):981-8.
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  45. Ametov AS, Barinov A, Dyck PJ, Hermann R, Kozlova N, Litchy WJ, Low PA, Nehrdich D, Novosadova M, O'Brien PC, Reljanovic M, Samigullin R, Schuette K, Strokov I, Tritschler H, Wessel K, Yakhno N, Ziegler D. The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid - The SYDNEY trial. Diabetes Care. 2003 Mar; 26(3):770-6.
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  46. Vella A, Service FJ, O'Brien PC. Glucose counterregulatory hormones in the 72-hour fast. Endocr Pract. 2003 Mar-Apr; 9(2):115-8.
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  47. Thomas RJ, Palumbo PJ, Melton LJ, Roger VL, Ransom J, O'Brien PC, Leibson CL. Trends in the mortality burden associated with diabetes mellitus - A population-based study in Rochester, Minn, 1970-1994. Arch Intern Med. 2003 Feb 24; 163(4):445-51.
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  48. Gerber TC, O'Brien PC, Pastor K, Kuzo RS, Blackshear JL, Morin RL. Evaluation of reconstruction windows for multislice computed tomography in quantification of coronary calcium. Invest Radiol. 2003 Feb; 38(2):108-18.
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  49. Dyck PJ, Litchy WJ, Daube JR, Harper CM, Dyck PJB, Davies J, O'Brien PC. Individual attributes versus composite scores of nerve conduction abnormality: Sensitivity, reproducibility, and concordance with impairment. Muscle & Nerve. 2003 Feb; 27(2):202-10.
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  50. Jack CR Jr, Slomkowski M, Gracon S, Hoover TM, Felmlee JP, Stewart K, Xu Y, Shiung M, O'Brien PC, Cha R, Knopman D, Petersen RC. MRI as a biomarker of disease progression in a therapeutic trial of milameline for AD. Neurology. 2003 Jan 28; 60(2):253-60.
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  51. Willis F, Graff-Radford N, Pinto M, Lawson L, Adamson J, Epstein D, Parfitt F, Hutton M, O'Brien PC. Apolipoprotein epsilon4 allele frequency in young Africans of Ugandan descent versus African Americans. J Natl Med Assoc. 2003 Jan; 95(1):71-6.
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  52. Gerber TC, Kuzo RS, Lane GE, O'Brien PC, Karstaedt N, Morin RL, Safford RE, Blackshear JL, Pietan JH. Image quality in a standardized algorithm for minimally invasive coronary angiography with multislice spiral computed tomography. J Comput Assist Tomogr. 2003 Jan-Feb; 27(1):62-9.
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  53. Radhakrishnan K, So EL, Silbert PL, Cascino GD, Marsh WR, Cha RH, O'Brien PC. Prognostic implications of seizure recurrence in the first year after anterior temporal lobectomy. Epilepsia. 2003 Jan; 44(1):77-80.
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  54. Ukleja A, Scolapio JS, McConnell JP, Dickson RC, Nguyen JH, O'Brien PC. Serum and hepatic vitamin E assessment in cirrhotics before transplantation. JPEN J Parenter Enteral Nutr. 2003 Jan-Feb; 27(1):71-3.
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  55. Bratton RL, Montero DP, Adams KS, Novas MA, McKay TC, Hall LJ, Foust JG, Mueller MB, O'Brien PC, Atkinson EJ, Maurer MS. Effect of "ionized" wrist bracelets on musculoskeletal pain: a randomized, double-blind, placebo-controlled trial. Mayo Clin Proc. 2002 Nov; 77(11):1164-8.
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  56. Parashos SA, Maraganore DM, O'Brien PC, Rocca WA. Medical services utilization and prognosis in Parkinson disease: A population-based study. Mayo Clin Proc. 2002 Sep; 77(9):918-25.
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  57. Dyck PJ, Turner DW, Davies JL, O'Brien PC, Dyck PJB, Rask CA, rhNGF Group. Electronic case-report forms of symptoms and impairments of peripheral neuropathy. Can J Neurol Sci. 2002 Aug; 29(3):258-66.
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  58. Edland SD, Xu Y, Plevak M, O'Brien P, Tangalos EG, Petersen RC, Jack CR. Total intracranial volume: Normative values and lack of association with Alzheimer's disease. Neurology. 2002 Jul 23; 59(2):272-4.
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  59. Hellinger WC, Yao JD, Alvarez S, Blair JE, Cawley JJ, Paya CV, O'Brien PC, Spivey JR, Dickson RC, Harnois DM, Douglas DD, Hughes CB, Nguyen JH, Mulligan DC, Steers JL. A randomized, prospective, double-blinded evaluation of selective bowel decontamination in liver transplantation. Transplantation. 2002 Jun 27; 73(12):1904-9.
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  60. Burns TM, Taly A, O'Brien PC, Dyck PJ. Clinical versus quantitative vibration assessment: improving clinical performance. J Peripher Nerv Syst. 2002 Jun; 7(2):112-7.
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  61. Burke JP, O'Brien P, Ransom J, Palumbo PJ, Lydick E, Yawn BP, Melton LJ, Leibson CL. Impact of case ascertainment on recent trends in diabetes incidence in Rochester, Minnesota. Am J Epidemiol. 2002 May 1; 155(9):859-65.
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  62. Ukleja A, Scolapio JS, McConnell JP, Spivey JR, Dickson RC, Nguyen JH, O'Brien PC. Nutritional assessment of serum and hepatic vitamin A levels in patients with cirrhosis. JPEN J Parenter Enteral Nutr. 2002 May-Jun; 26(3):184-8.
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  63. Jack CR Jr, Dickson DW, Parisi JE, Xu YC, Cha RH, O'Brien PC, Edland SD, Smith GE, Boeve BF, Tangalos EG, Kokmen E, Petersen RC. Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. Neurology. 2002 Mar 12; 58(5):750-7.
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  64. Scolapio JS, Ukleja A, McGreevy K, Burnett OL, O'Brien PC. Nutritional problems in end-stage liver disease - Contribution of impaired gastric emptying and ascites. J Clin Gastroenterol. 2002 Jan; 34(1):89-93.
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  65. Kantarci K, Xu Y, Shiung MM, O'Brien PC, Cha RH, Smith GE, Ivnik RJ, Boeve BF, Edland SD, Kokmen E, Tangalos EG, Petersen RC, Jack CR Jr. Comparative diagnostic utility of different MR modalities in mild cognitive impairment and Alzheimer's disease. Dement Geriatr Cogn Disord. 2002; 14(4):198-207.
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  66. Meschia JF, Brown RD Jr, Brott TG, Hardy J, Atkinson EJ, O'Brien PC. Feasibility of an affected sibling pair study in ischemic stroke: results of a 2-center family history registry. Stroke. 2001 Dec 1; 32(12):2939-41.
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  67. Jack CR Jr, O'Brien PC, Rettman DW, Shiung MM, Xu Y, Muthupillai R, Manduca A, Avula R, Erickson BJ. FLAIR histogram segmentation for measurement of leukoaraiosis volume. J Magn Reson Imaging. 2001 Dec; 14(6):668-76.
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  68. Machulda MM, Ward HA, Cha R, O'Brien P, Jack CR Jr. Functional inferences vary with the method of analysis in fMRI. Neuroimage. 2001 Nov; 14(5):1122-7.
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  69. Dyck PJ, Velosa JA, Pach JM, Sterioff S, Larson TS, Norell JE, O'Brien PC, Dyck PJ. Increased weakness after pancreas and kidney transplantation. Transplantation. 2001 Oct 27; 72(8):1403-8.
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  70. Smith GE, O'Brien PC, Ivnik RJ, Kokmen E, Tangalos EG. Prospective analysis of risk factors for nursing home placement of dementia patients. Neurology. 2001 Oct 23; 57(8):1467-73.
  71. Service FJ, O'Brien PC. The relation of glycaemia to the risk of development and progression of retinopathy in the Diabetic Control and Complications Trial. Diabetologia. 2001 Oct; 44(10):1215-20.
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  72. Sencakova D, Graff-Radford NR, Willis FB, Lucas JA, Parfitt F, Cha RH, O'Brien PC, Petersen RC, Jack CR Jr. Hippocampal atrophy correlates with clinical features of Alzheimer disease in African Americans. Arch Neurol. 2001 Oct; 58(10):1593-7.
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  73. Suarez GA, Chalk CH, Russell JW, Kim SM, O'Brien PC, Dyck PJ. Diagnostic accuracy and certainty from sequential evaluations in peripheral neuropathy. Neurology. 2001 Sep 25; 57(6):1118-20.
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  74. Short RA, Bowen RL, O'Brien PC, Graff-Radford NR. Elevated gonadotropin levels in patients with Alzheimer disease. Mayo Clin Proc. 2001 Sep; 76(9):906-9.
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  75. Apfel SC, Asbury AK, Bril V, Burns TM, Campbell JN, Chalk CH, Dyck PJ, Dyck PJ, Feldman EL, Fields HL, Grant IA, Griffin JW, Klein CJ, Lindblom U, Litchy WJ, Low PA, Melanson M, Mendell JR, Merren MD, O'Brien PC, Rendell M, Rizza RA, Service FJ, Thomas Positive neuropathic sensory symptoms as endpoints in diabetic neuropathy trials. J Neurol Sci. 2001 Aug 15; 189(1-2):3-5.
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  76. Buskirk SJ, Pisansky TM, Atkinson EJ, Schild SE, O'Brien PC, Wolfe JT, Zincke H. Lymph node-positive prostate cancer: evaluation of the results of the combination of androgen deprivation therapy and radiation therapy. Mayo Clin Proc. 2001 Jul; 76(7):702-6.
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  77. Noseworthy JH, O'Brien PC, Petterson TM, Weis J, Stevens L, Peterson WK, Sneve D, Cross SA, Leavitt JA, Auger RG, Weinshenker BG, Dodick DW, Wingerchuk DM, Rodriguez M. A randomized trial of intravenous immunoglobulin in inflammatory demyelinating optic neuritis. Neurology. 2001 Jun 12; 56(11):1514-22.
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  78. Ahlman B, Charlton M, Fu A, Berg C, O'Brien P, Nair KS. Insulin's effect on synthesis rates of liver proteins. A swine model comparing various precursors of protein synthesis. Diabetes. 2001 May; 50(5):947-54.
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  79. Kantarci K, Jack CR Jr, Xu YC, Campeau NG, O'Brien PC, Smith GE, Ivnik RJ, Boeve BF, Kokmen E, Tangalos EG, Petersen RC. Mild cognitive impairment and Alzheimer disease: regional diffusivity of water. Radiology. 2001 Apr; 219(1):101-7.
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  80. Leibson CL, Katusic SK, Barbaresi WJ, Ransom J, O'Brien PC. Use and costs of medical care for children and adolescents with and without attention-deficit/hyperactivity disorder. JAMA. 2001 Jan 3; 285(1):60-6.
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  81. Noseworthy JH, O'Brien PC, Weinshenker BG, Weis JA, Petterson TM, Erickson BJ, Windebank AJ, Whisnant JP, Stolp-Smith KA, Harper CM Jr, Low PA, Romme LJ, Johnson M, An KN, Rodriguez M. IV immunoglobulin does not reverse established weakness in MS. Neurology. 2000 Oct 24; 55(8):1135-43.
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  82. Jack CR Jr, Petersen RC, Xu Y, O'Brien PC, Smith GE, Ivnik RJ, Boeve BF, Tangalos EG, Kokmen E. Rates of hippocampal atrophy correlate with change in clinical status in aging and AD. Neurology. 2000 Aug 22; 55(4):484-89.
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  83. Kimura K, Hunter SF, Thollander MS, Loftus EV Jr, Melton LJ 3rd, O'Brien PC, Rodriguez M, Phillips SF. Concurrence of inflammatory bowel disease and multiple sclerosis. Mayo Clin Proc. 2000 Aug; 75(8):802-6.
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  84. Kantarci K, Jack CR Jr, Xu YC, Campeau NG, O'Brien PC, Smith GE, Ivnik RJ, Boeve BF, Kokmen E, Tangalos EG, Petersen RC. Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS study. Neurology. 2000 Jul 25; 55(2):210-7.
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  85. Mosewich RK, So EL, O'Brien TJ, Cascino GD, Sharbrough FW, Marsh WR, Meyer FB, Jack CR, O'Brien PC. Factors predictive of the outcome of frontal lobe epilepsy surgery. Epilepsia. 2000 Jul; 41(7):843-9.
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  86. Weinshenker BG, Hebrink DD, Klein C, Atkinson EJ, O'Brien PC, McMurray CT. Genetic variation in the B7-1 gene in patients with multiple sclerosis. J Neuroimmunol. 2000 Jun 26; 105(2):184-8.
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  87. Xu Y, Jack CR Jr, O'Brien PC, Kokmen E, Smith GE, Ivnik RJ, Boeve BF, Tangalos RG, Petersen RC. Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD. Neurology. 2000 May 9; 54(9):1760-7.
  88. Smith GE, Kokmen E, O'Brien PC. Risk factors for nursing home placement in a population-based dementia cohort. J Am Geriatr Soc. 2000 May; 48(5):519-25.
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  89. Meschia JF, Brott TG, Chukwudelunzu FE, Hardy J, Brown RD Jr, Meissner I, Hall LJ, Atkinson EJ, O'Brien PC. Verifying the stroke-free phenotype by structured telephone interview. Stroke. 2000 May; 31(5):1076-80.
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  90. Klingler PJ, Hinder RA, Wetscher GJ, Davis DM, Achem SR, Seelig MH, O'Brien P, DeVault KR. Accurate placement of the esophageal pH electrode for 24-hour pH monitoring using a combined pH/manometry probe. Am J Gastroenterol. 2000 Apr; 95(4):906-9.
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  91. Dyck PJ, Dyck PJB, Velosa JA, Larson TS, O'Brien PC. Patterns of quantitative sensation testing of hypoesthesia and hyperalgesia are predictive of diabetic polyneuropathy - a study of three cohorts. Diabetes Care. 2000 Apr; 23(4):510-517.
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  92. Petersen RC, Jack CR Jr, Xu YC, Waring SC, O'Brien PC, Smith GE, Ivnik RJ, Tangalos EG, Boeve BF, Kokmen E. Memory and MRI-based hippocampal volumes in aging and AD. Neurology. 2000 Feb 8; 54(3):581-7.
  93. Beard CM, Hartmann LC, Keeney GL, Crowson CS, Malkasian GD, O'Brien PC, Melton LJ 3rd. Endometrial cancer in Olmsted County, MN: trends in incidence, risk factors and survival. Ann Epidemiol. 2000 Feb; 10(2):97-105.
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  94. Beard CM, Hartmann LC, Atkinson EJ, O'Brien PC, Malkasian GD, Keeney GL, Melton LJ 3rd. The epidemiology of ovarian cancer: a population-based study in Olmsted County, Minnesota, 1935-1991. Ann Epidemiol. 2000 Jan; 10(1):14-23.
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  95. Larson TS, Santanello N, Shahinfar S, O'Brien PC, Palumbo PJ, Melton LJ 3rd, Leibson CL. Trends in persistent proteinuria in adult-onset diabetes: a population-based study. Diabetes Care. 2000 Jan; 23(1):51-6.
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  96. Waring SC, Rocca WA, Petersen RC, O'Brien PC, Tangalos EG, Kokmen E. Postmenopausal estrogen replacement therapy and risk of Alzheimer's disease: a population based study. Menopause Dig. 2000; 12:6-7.
  97. Weinshenker BG, O'Brien PC, Petterson TM, Noseworthy JH, Lucchinetti CF, Dodick DW, Pineda AA, Stevens LN, Rodriguez M. A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease. Ann Neurol. 1999 Dec; 46(6):878-86.
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  98. Wingerchuk DM, Hogancamp WF, O'Brien PC, Weinshenker BG. The clinical course of neuromyelitis optica (Devic's syndrome). Neurology. 1999 Sep 22; 53(5):1107-14.
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  99. Proctor DN, O'Brien PC, Atkinson EJ, Nair KS. Comparison of techniques to estimate total body skeletal muscle mass in people of different age groups. Am J Physiol. 1999 Sep; 277(3 Pt 1):E489-95.
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  100. Myllykangas L, Polvikoski T, Sulkava R, Verkkoniemi A, Crook R, Tienari PJ, Pusa AK, Niinisto L, O'Brien P, Kontula K, Hardy J, Haltia M, Perez-Tur J. Genetic association of alpha(2)-macroglobulin with Alzheimer's disease in a Finnish elderly population. Ann Neurol. 1999 Sep; 46(3):382-90.
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  101. Dyck PJ, Davies JL, Wilson DM, Service FJ, Melton LJ 3rd, O'Brien PC. Risk factors for severity of diabetic polyneuropathy: intensive longitudinal assessment of the Rochester Diabetic Neuropathy Study cohort. Diabetes Care. 1999 Sep; 22(9):1479-86.
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  102. Leibson C, Owens T, O'Brien P, Waring S, Tangalos E, Hanson V, Plevak M, Kokmen E. Use of physician and acute care services by persons with and without Alzheimer's disease: a population-based comparison. J Am Geriatr Soc. 1999 Jul; 47(7):864-9.
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  103. Jensen MD, Hensrud D, O'Brien PC, Nielsen S. Collection and interpretation of plasma leptin concentration data in humans. Obes Res. 1999 May; 7(3):241-5.
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  104. Weinshenker BG, Hebrink D, Wingerchuk DM, Klein CJ, Atkinson E, O'Brien PC, McMurray CT. Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS. Neurology. 1999 Apr 22; 52(7):1500-3.
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  105. Jack CR Jr, Petersen RC, Xu YC, O'Brien PC, Smith GE, Ivnik RJ, Boeve BF, Waring SC, Tangalos EG, Kokmen E. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology. 1999 Apr 22; 52(7):1397-403.
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  106. Waring SC, Rocca WA, Petersen RC, O'Brien PC, Tangalos EG, Kokmen E. Postmenopausal estrogen replacement therapy and risk of AD: a population-based study. Neurology. 1999 Mar 23; 52(5):965-70.
  107. Suarez GA, Opfer-Gehrking TL, Offord KP, Atkinson EJ, O'Brien PC, Low PA. The Autonomic Symptom Profile: a new instrument to assess autonomic symptoms. Neurology. 1999 Feb; 52(3):523-8.
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  108. Ahlskog JE, Waring SC, Petersen RC, Esteban-Santillan C, Craig UK, O'Brien PC, Plevak MF, Kurland LT. Olfactory dysfunction in Guamanian ALS, parkinsonism, and dementia. Neurology. 1998 Dec; 51(6):1672-7.
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  109. Novak V, Novak P, Opfer-Gehrking TL, O'Brien PC, Low PA. Clinical and laboratory indices that enhance the diagnosis of postural tachycardia syndrome. Mayo Clin Proc. 1998 Dec; 73(12):1141-50.
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  110. Wu CL, Denq JC, Harper CM, O'Brien PC, Low PA. Clinical and electrophysiologic attributes as predictors of results of autonomic function tests. Clin Auton Res. 1998 Dec; 8(6):347-51.
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  111. Ficker DM, So EL, Shen WK, Annegers JF, O'Brien PC, Cascino GD, Belau PG. Population-based study of the incidence of sudden unexplained death in epilepsy. Neurology. 1998 Nov; 51(5):1270-4.
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  112. Noseworthy JH, O'Brien P, Erickson BJ, Lee D, Sneve D, Ebers GC, Rice GP, Auty A, Hader WJ, Kirk A, Duquette P, Carter J, Francis G, Metz L, Shuster E, Mayo Clinic-Canadian Cooperative MS Study Group. The Mayo Clinic-Canadian Cooperative trial of sulfasalazine in active multiple sclerosis. Neurology. 1998 Nov; 51(5):1342-52.
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  113. Denq JC, O'Brien PC, Low PA. Normative data on phases of the Valsalva maneuver. J Clin Neurophysiol. 1998 Nov; 15(6):535-40.
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  114. Jack CR Jr, Petersen RC, Xu Y, O'Brien PC, Smith GE, Ivnik RJ, Tangalos EG, Kokmen E. Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease. Neurology. 1998 Oct; 51(4):993-9.
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  115. Beard CM, Waring SC, O'Brien PC, Kurland LT, Kokmen E. Nonsteroidal anti-inflammatory drug use and Alzheimer's disease: a case-control study in Rochester, Minnesota, 1980 through 1984. Mayo Clin Proc. 1998 Oct; 73(10):951-5.
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  116. Chabolla DR, Maraganore DM, Ahlskog JE, O'Brien PC, Rocca WA. Drug-induced parkinsonism as a risk factor for Parkinson's disease: a historical cohort study in Olmsted County, Minnesota. Mayo Clin Proc. 1998 Aug; 73(8):724-7.
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  117. Radhakrishnan K, So EL, Silbert PL, Jack CR Jr, Cascino GD, Sharbrough FW, O'Brien PC. Predictors of outcome of anterior temporal lobectomy for intractable epilepsy: a multivariate study. Neurology. 1998 Aug; 51(2):465-71.
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  118. Stolp-Smith KA, Atkinson EJ, Campion ME, O'Brien PC, Rodriguez M. Health care utilization in multiple sclerosis: a population-based study in Olmsted County, MN. Neurology. 1998 Jun; 50(6):1594-600.
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  119. Dyck PJ, Dyck PJB, Kennedy WR, Kesserwani H, Melanson M, Ochoa J, Shy M, Stevens JC, Suarez GA, O'Brien PC. Limitations of quantitative sensory testing when patients are biased toward a bad outcome. Neurology. 1998 May; 50(5):1213.
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  120. Moller N, O'Brien P, Nair KS. Disruption of the relationship between fat content and leptin levels with aging in humans. J Clin Endocrinol Metab. 1998 Mar; 83(3):931-4.
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  121. Jack CR Jr, Petersen RC, Xu YC, O'Brien PC, Waring SC, Tangalos EG, Smith GE, Ivnik RJ, Thibodeau SN, Kokmen E. Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease. Ann Neurol. 1998 Mar; 43(3):303-10.
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  122. Wijdicks EF, Kokmen E, O'Brien PC. Measurement of impaired consciousness in the neurological intensive care unit: a new test. Journal of Neurology, Neurosurgery & Psychiatry. 1998 Jan; 64(1):117-9.
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  123. Kokmen E, Ozekmekci FS, Cha RH, Obrien PJ. Testing for apraxia in neurological patients - a descriptive study in two diverse cultures. Eur J Neurol. 1998; 5(2):175-180.
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  124. Schrock E, Veldman T, Padilla-Nash H, Ning Y, Spurbeck J, Jalal S, Shaffer LG, Papenhausen P, Kozma C, Phelan MC, Kjeldsen E, Schonberg SA, O'Brien P, Biesecker L, du Manoir S, Ried T. Spectral karyotyping refines cytogenetic diagnostics of constitutional chromosomal abnormalities. Hum Genet. 1997 Dec; 101(3):255-62.
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  125. Low PA, Denq JC, Opfer-Gehrking TL, Dyck PJ, O'Brien PC, Slezak JM. Effect of age and gender on sudomotor and cardiovagal function and blood pressure response to tilt in normal subjects. Muscle & Nerve. 1997 Dec; 20(12):1561-8.
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  126. Lucchinetti CF, Kiers L, O'Duffy A, Gomez MR, Cross S, Leavitt JA, O'Brien P, Rodriguez M. Risk factors for developing multiple sclerosis after childhood optic neuritis. Neurology. 1997 Nov; 49(5):1413-8.
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  127. Campeau NG, Petersen RC, Felmlee JP, O'Brien PC, Jack CR Jr. Hippocampal transverse relaxation times in patients with Alzheimer disease. Radiology. 1997 Oct; 205(1):197-201.
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  128. Leibson CL, Rocca WA, Hanson VA, Cha R, Kokmen E, O'Brien PC, Palumbo PJ. The risk of dementia among persons with diabetes mellitus: a population-based cohort study. Ann N Y Acad Sci. 1997 Sep 26(826):422-7.
  129. Jack CR Jr, Petersen RC, Xu YC, Waring SC, O'Brien PC, Tangalos EG, Smith GE, Ivnik RJ, Kokmen E. Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease. Neurology. 1997 Sep; 49(3):786-94.
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  130. Service FJ, O'Brien PC, Wise SD, Ness S, LeBlanc SM. Dermal interstitial glucose as an indicator of ambient glycemia. Diabetes Care. 1997 Sep; 20(9):1426-9.
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  131. Dyck PJ, Melton LJ, Obrien PC, Service FJ. Approaches to improve epidemiological studies of diabetic neuropathy - insights from the Rochester Diabetic Neuropathy Study. Diabetes. 1997 Sep; 46(Suppl 2):S 5-S 8.
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  132. Leibson CL, O'Brien PC, Atkinson E, Palumbo PJ, Melton LJ 3rd. Relative contributions of incidence and survival to increasing prevalence of adult-onset diabetes mellitus: a population-based study. Am J Epidemiol. 1997 Jul 1; 146(1):12-22.
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  133. Dyck PJ, Davies JL, Litchy WJ, O'Brien PC. Longitudinal assessment of diabetic polyneuropathy using a composite score in the Rochester Diabetic Neuropathy Study cohort. Neurology. 1997 Jul; 49(1):229-39.
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  134. Reeves AL, So EL, Evans RW, Cascino GD, Sharbrough FW, O'Brien PC, Trenerry MR. Factors associated with work outcome after anterior temporal lobectomy for intractable epilepsy. Epilepsia. 1997 Jun; 38(6):689-95.
  135. Graff-Radford NR, Lin SC, Brazis PW, Bolling JP, Liesegang TJ, Lucas JA, Uitti RJ, O'Brien PC. Tropicamide eyedrops cannot be used for reliable diagnosis of Alzheimer's disease. Mayo Clin Proc. 1997 Jun; 72(6):495-504.
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  136. O'Brien PC, Geller NL. Interpreting tests for efficacy in clinical trials with multiple endpoints. Control Clin Trials. 1997 Jun; 18(3):222-7.
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  137. So EL, Radhakrishnan K, Silbert PL, Cascino GD, Sharbrough FW, O'Brien PC. Assessing changes over time in temporal lobectomy: outcome by scoring seizure frequency. Epilepsy Res. 1997 May; 27(2):119-25.
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  138. Low PA, Opfer-Gehrking TL, Zimmerman IR, O'Brien PC. Evaluation of heart rate changes: electrocardiographic versus photoplethysmographic methods. Clin Auton Res. 1997 Apr; 7(2):65-8.
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  139. Beard CM, Kokmen E, O'Brien PC, Ania BJ, Melton LJ 3rd. Risk of Alzheimer's disease among elderly patients with anemia: population-based investigations in Olmsted County, Minnesota. Ann Epidemiol. 1997 Apr; 7(3):219-24.
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  140. Engelstad JK, Davies JL, Giannini C, O'Brien PC, Dyck PJ. No evidence for axonal atrophy in human diabetic polyneuropathy. Journal of Neuropathology & Experimental Neurology. 1997 Mar; 56(3):255-62.
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  141. Leibson CL, Rocca WA, Hanson VA, Cha R, Kokmen E, O'Brien PC, Palumbo PJ. Risk of dementia among persons with diabetes mellitus: a population-based cohort study. Am J Epidemiol. 1997 Feb 15; 145(4):301-8.
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  142. Dyck PJ, Peroutka S, Rask C, Burton E, Baker MK, Lehman KA, Gillen DA, Hokanson JL, O'Brien PC. Intradermal recombinant human nerve growth factor induces pressure allodynia and lowered heat-pain threshold in humans. Neurology. 1997 Feb; 48(2):501-5.
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  143. Service FJ, Rizza RA, Zimmerman BR, Dyck PJ, O'Brien PC, Melton LJ 3rd. The classification of diabetes by clinical and C-peptide criteria. A prospective population-based study. Diabetes Care. 1997 Feb; 20(2):198-201.
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  144. Beard CM, Kokmen E, Sigler C, Smith GE, Petterson T, O'Brien PC. Cause of death in Alzheimer's disease. Ann Epidemiol. 1996 May; 6(3):195-200.
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  145. Dyck PJ, Zimmerman IR, Johnson DM, Gillen D, Hokanson JL, Karnes JL, Gruener G, O'Brien PC. A standard test of heat-pain responses using CASE IV. J Neurol Sci. 1996 Mar; 136(1-2):54-63.
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  146. Kokmen E, Beard CM, O'Brien PC, Kurland LT. Epidemiology of dementia in Rochester, Minnesota. Mayo Clin Proc. 1996 Mar; 71(3):275-82.
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  147. So EL, Annegers JF, Hauser WA, O'Brien PC, Whisnant JP. Population-based study of seizure disorders after cerebral infarction. Neurology. 1996 Feb; 46(2):350-5.
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  148. Kokmen E, Ozsarfati Y, Beard CM, O'Brien PC, Rocca WA. Impact of referral bias on clinical and epidemiological studies of Alzheimer's disease. J Clin Epidemiol. 1996 Jan; 49(1):79-83.
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  149. Kane LA, Service FJ, O'Brien PC, et al. Correlations of plasma concentrations of beta-cell polypeptides with pathological features of insulinomas Endocrine Practice. 1996; 2:1-3.
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  150. Safford RE, The Program Committee Florida Chapter American College of Cardiology. Coronary revascularization in the elderly: Florida multicenter consecutive case experience with coronary revascularization in patients age 75 years and older. Compr Ther. 1996; 22(8):477-484.
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  151. Chelimsky TC, Low PA, Naessens JM, Wilson PR, Amadio PC, O'Brien PC. Value of autonomic testing in reflex sympathetic dystrophy. Mayo Clin Proc. 1995 Nov; 70(11):1029-40.
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  152. Albers JW, Anderson H, Arezzo JC, Asbury A, Bolton C, Boulton AJM, Bril V, Brown M, Brownlee M, Canal N, Chalk C, Donaghy M, Dyck PJ, Feasby T, Giannini C, Goto Y, Grant I, Greene D, Griffin J, et al. Diabetic polyneuropathy in controlled clinical trials - consensus report of the Peripheral Nerve Society. Ann Neurol. 1995 Sep; 38:478-482.
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  153. Low PA, Opfer-Gehrking TL, Dyck PJ, Litchy WJ, O'Brien PC. Double-blind, placebo-controlled study of the application of capsaicin cream in chronic distal painful polyneuropathy. Pain. 1995 Aug; 62(2):163-8.
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  154. Butkiewicz EK, Leibson CL, O'Brien PC, Palumbo PJ, Rizza RA. Insulin therapy for diabetic ketoacidosis. Bolus insulin injection versus continuous insulin infusion. Diabetes Care. 1995 Aug; 18(8):1187-90.
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  155. Jack CR Jr, Trenerry MR, Cascino GD, Sharbrough FW, So EL, O'Brien PC. Bilaterally symmetric hippocampi and surgical outcome. Neurology. 1995 Jul; 45(7):1353-8.
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  156. Ahlskog JE, Waring SC, Kurland LT, Petersen RC, Moyer TP, Harmsen WS, Maraganore DM, O'Brien PC, Esteban-Santillan C, Bush V. Guamanian neurodegenerative disease - investigation of the calcium metabolism heavy metal hypothesis. Neurology. 1995 Jul; 45:1340-4.
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  157. Dyck PJ, Litchy WJ, Lehman KA, Hokanson JL, Low PA, O'Brien PC. Variables influencing neuropathic endpoints: the Rochester Diabetic Neuropathy Study of Healthy Subjects. Neurology. 1995 Jun; 45(6):1115-21.
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  158. Rodriguez M, Siva A, Cross SA, O'Brien PC, Kurland LT. Optic neuritis: a population-based study in Olmsted County, Minnesota. Neurology. 1995 Feb; 45(2):244-50.
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  159. Beard CM, Kokmen E, O'Brien PC, Kurland LT. The prevalence of dementia is changing over time in Rochester, Minnesota. Neurology. 1995 Jan; 45(1):75-9.
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  160. O'Brien PC, Dyck PJ. Procedures for setting normal values. Neurology. 1995 Jan; 45(1):17-23.
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  161. Dyck PJ, Litchy WJ, Kratz KM, Suarez GA, Low PA, Pineda AA, Windebank AJ, Karnes JL, O'Brien PC. A plasma exchange versus immune globulin infusion trial in chronic inflammatory demyelinating polyradiculoneuropathy. Ann Neurol. 1994 Dec; 36(6):838-45.
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  162. Noseworthy JH, O'Brien PC, van Engelen BG, Rodriguez M. Intravenous immunoglobulin therapy in multiple sclerosis: progress from remyelination in the Theiler's virus model to a randomised, double-blind, placebo-controlled clinical trial. J Neurol Neurosurg Psychiatry. 1994 Nov; 57 Suppl:11-4.
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  163. Beard CM, Kokmen E, O'Brien PC, Kurland LT. Are patients with Alzheimer's disease surviving longer in recent years? Neurology. 1994 Oct; 44(10):1869-71.
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  164. Jack CR, Krecke KN, Luetmer PH, Cascino GD, Sharbrough FW, O'Brien PC, Parisi JE. Diagnosis of mesial temporal sclerosis with conventional versus fast spin-echo MR imaging. Radiology. 1994 Jul; 192(1):123-7.
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  165. Kokmen E, Ozekmekci FS, Beard CM, O'Brien PC, Kurland LT. Incidence and prevalence of Huntington's disease in Olmsted County, Minnesota (1950 through 1989). Arch Neurol. 1994 Jul; 51(7):696-8.
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  166. Jack CR Jr, Mullan BP, Sharbrough FW, Cascino GD, Hauser MF, Krecke KN, Luetmer PH, Trenerry MR, O'Brien PC, Parisi JE. Intractable nonlesional epilepsy of temporal lobe origin: lateralization by interictal SPECT versus MRI. Neurology. 1994 May; 44(5):829-36.
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  167. Waring SC, O'Brien PC, Kurland LT, Thibodeau SN, Tsai MS, Petersen RC, Estebansantillan CE. Apolipoprotein E allele in Chamorros with amyotrophic lateral sclerosis Parkinsonism-dementia complex. Lancet. 1994 Mar 5; 343:611.
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  168. Ballard DJ, Bryant SC, O'Brien PC, Smith SC, Pine MB, Cortese DA. Referral selection bias in the medicare hospital mortality prediction model: are centers of referral for medicare beneficiaries necessarily centers of excellence? Health Serv Res. 1994 Feb; 28:6.
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  169. Gough DB, Donohue JH, Schutt AJ, Gonchoroff N, Goellner JR, Wilson TO, Naessens JM, O'Brien PC, van Heerden JA. Pseudomyxoma peritonei. Long-term patient survival with an aggressive regional approach. Ann Surg. 1994 Feb; 219(2):112-9.
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  170. Dinneen SF, Silverberg JD, Batts KP, O'Brien PC, Ballard DJ, Rizza RA. Liver iron stores in patients with non-insulin-dependent diabetes mellitus. Mayo Clin Proc. 1994 Jan; 69(1):13-5.
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  171. Rodriguez M, Siva A, Ward J, Stolp-Smith K, O'Brien P, Kurland L. Impairment, disability, and handicap in multiple sclerosis: a population-based study in Olmsted County, Minnesota. Neurology. 1994 Jan; 44(1):28-33.
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  172. O'Brien PC. Discussion in: Deconstructing statistical questions by DJ Hand. J Royal Statistical Soc Series. 1994; A 35(157):350.
  173. O'Brien PC. Discussion. Stat Med. 1993 Dec 15; 12:2245-2246.
  174. Thompson GB, Service FJ, van Heerden JA, Carney JA, Charboneau JW, O'Brien PC, Grant CS. Reoperative insulinomas, 1927 to 1992: an institutional experience. Surgery. 1993 Dec; 114(6):1196-204; discussion 1205-6.
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  175. Gough DB, Donohue JH, Evans MM, Pernicone PJ, Wold LE, Naessens JM, O'Brien PC. A 50-year experience of male breast cancer: is outcome changing? Surg Oncol. 1993 Dec; 2(6):325-33.
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  176. Siva A, Radhakrishnan K, Kurland LT, O'Brien PC, Swanson JW, Rodriguez M. Trauma and multiple sclerosis: a population-based cohort study from Olmsted County, Minnesota. Neurology. 1993 Oct; 43(10):1878-82.
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  177. Kokmen E, Beard CM, O'Brien PC, Offord K, Kurland LT. Is the incidence of dementing illness changing? Neurology. 1993 Oct; 43:1887-1892.
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  178. Uitti RJ, Ahlskog JE, Maraganore DM, Muenter MD, Atkinson EJ, Cha RH, O'Brien PC. Levodopa therapy and survival in idiopathic Parkinson's disease: Olmsted County project. Neurology. 1993 Oct; 43(10):1918-26.
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  179. Cascino GD, So EL, Sharbrough FW, Strelow D, Lagerlund TD, Milde LN, O'Brien PC. Alfentanil-induced epileptiform activity in patients with partial epilepsy. J Clin Neurophysiol. 1993 Oct; 10(4):520-5.
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  180. O'Brien T, Dinneen SF, O'Brien PC, Palumbo PJ. Hyperlipidemia in patients with primary and secondary hypothyroidism. Mayo Clin Proc. 1993 Sep; 68(9):860-6.
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  181. Jensen MD, Kanaley JA, Roust LR, O'Brien PC, Braun JS, Dunn WL, Wahner HW. Assessment of body composition with use of dual-energy absorptiometry: evaluation and comparison with other methods. Mayo Clin Proc. 1993 Sep; 68:867-873.
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  182. Dyck PJ, Zimmerman I, Gillen DA, Johnson D, Karnes JL, O'Brien PC. Cool, warm, and heat-pain detection thresholds: testing methods and inferences about anatomic distribution of receptors. Neurology. 1993 Aug; 43(8):1500-8.
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  183. Dyck PJ, O'Brien PC, Kosanke JL, Gillen DA, Karnes JL. A 4, 2, and 1 stepping algorithm for quick and accurate estimation of cutaneous sensation threshold. Neurology. 1993 Aug; 43(8):1508-12.
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  184. O'Brien T, O'Brien PC, Service FJ. Insulin surrogates in insulinoma. J Clin Endocrinol Metab. 1993 Aug; 77(2):448-51.
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  185. Butler PC, Caumo A, Zerman A, O'Brien PC, Cobelli C, Rizza RA. Methods for assessment of the rate of onset and offset of insulin action during nonsteady state in humans. Am J Physiol. 1993 Apr; 264(4 Pt 1):E548-60.
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  186. Dyck PJ, Kratz KM, Karnes JL, Litchy WJ, Klein R, Pach JM, Wilson DM, O'Brien PC, Melton LJ 3rd, Service FJ. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology. 1993 Apr; 43(4):817-24.
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  187. Melton LJ 3rd, Dyck PJ, Karnes JL, O'Brien PC, Service FJ. Non-response bias in studies of diabetic complications: the Rochester Diabetic Neuropathy Study. J Clin Epidemiol. 1993 Apr; 46(4):341-8.
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  188. Douglas DD, Rakela J, Lin HJ, Hollinger FB, Taswell HF, Czaja AJ, Gross JB, Anderson ML, Parent K, Fleming CR, et al. Randomized controlled trial of recombinant alpha-2a-interferon for chronic hepatitis C. Comparison of alanine aminotransferase normalization versus loss of HCV RNA and anti-HCV IgM. Dig Dis Sci. 1993 Apr; 38(4):601-7.
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  189. Service FJ, O'Brien PC, McMahon MM, Kao PC. C-peptide during the prolonged fast in insulinoma. J Clin Endocrinol Metab. 1993 Mar; 76(3):655-9.
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  190. O'Brien T, Young WF Jr, Palumbo PJ, O'Brien PC, Service FJ. Hypertension and dyslipidemia in patients with insulinoma. Mayo Clin Proc. 1993 Feb; 68(2):141-6.
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  191. Kaplan J, Fredrickson PA, Renaux SA, O'Brien PC. Theophylline effect on sleep in normal subjects. Chest. 1993 Jan; 103(1):193-5.
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  192. Ory SJ, Nnadi E, Hermann RC Jr, O'Brien PC, Melton LJ. Fertility following ectopic pregnancy. Fertil Steril. 1993; 60:231-235.
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  193. O'Brien PC. A multivariate extension of von Neumann's ratio Communications in Statistics Theory and Methods. 1993; 23:239-48.
  194. O'Brien PC. Discussion on: Comparison of two tests useful in situations where treatment is expected to increase variability relative to controls, by Blair and Sawilowsky. Statistics in Medicine , 1993; 12:2245-6.
  195. Dyck PJ, Karnes JL, O'Brien PC, Litchy WJ, Low PA, Melton LJ 3rd. The Rochester Diabetic Neuropathy Study: reassessment of tests and criteria for diagnosis and staged severity. Neurology. 1992 Jun; 42(6):1164-70.
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  196. Jack CR, Sharbrough FW, Cascino GD, Hirschorn KA, O'Brien PC, Marsh WR. Magnetic resonance image-based hippocampal volumetry: correlation with outcome after temporal lobectomy. Ann Neurol. 1992 Feb; 31(2):138-46.
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  197. Fairbanks VF, Ziesmer SC, O'Brien PC. Methods for measuring plasma hemoglobin in micromolar concentration compared. Clin Chem. 1992 Jan; 38(1):132-40.
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  198. Service FJ, O'Brien PC, Kao PC, Young WF Jr. C-peptide suppression test: effects of gender, age, and body mass index; implications for the diagnosis of insulinoma. J Clin Endocrinol Metab. 1992 Jan; 74(1):204-10.
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  199. O'Brien PC. Robust procedures for testing equality of covariance matrices Biometrics. 1992; 48:819-27.
  200. Jack CR, Petersen RC, O'Brien PC, Tangalos EG. MR-Based Hippocampal Volumetry in the Diagnosis of Alzheimer's Disease Neurology. 1992; 42(1):183-8.
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  201. O'Brien PC. Commentary in: A clinical trial endpoint based on subjective rankings, by Follman D, Wittes J, Cutler JA. Statistics in Medicine , 1992; 11:447-9.
  202. O'Brien PC. Commentary in: On the use of the generalized t and generalized rank-sum statistics in medical research, by Blair RC and Morel, JG. Statistics in Medicine , 1992; 11:503-5.
  203. Cascino GD, Sharbrough FW, Jack CR Jr, Parisi JE, O'Brien PC. Acute depth electrode investigations in temporal lobe epilepsy: correlation with magnetic-resonance-imaging-based volume studies and pathology. J Epilepsy. 1992; 5(1):49-54.
  204. Armon C, Daube JR, O'Brien PC, Kurland LT, Mulder DW. When is an apparent excess of neurologic cases epidemiologically significant? Neurology. 1991 Nov; 41(11):1713-8.
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  205. Williams DB, Annegers JF, Kokmen E, O'Brien PC, Kurland LT. Brain injury and neurologic sequelae: a cohort study of dementia, parkinsonism, and amyotrophic lateral sclerosis. Neurology. 1991 Oct; 41(10):1554-7.
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  206. Patick AK, Thiemann RL, O'Brien PC, Rodriguez M. Persistence of Theiler's virus infection following promotion of central nervous system remyelination. Journal of Neuropathology & Experimental Neurology. 1991 Sep; 50(5):523-37.
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  207. Service FJ, McMahon MM, O'Brien PC, Ballard DJ. Functioning insulinoma--incidence, recurrence, and long-term survival of patients: a 60-year study. Mayo Clin Proc. 1991 Jul; 66(7):711-9.
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  208. Armon C, Kurland LT, Daube JR, O'Brien PC. Epidemiologic correlates of sporadic amyotrophic lateral sclerosis. Neurology. 1991 Jul; 41(7):1077-84.
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  209. Freeman WK, Schaff HV, O'Brien PC, Orszulak TA, Naessens JM, Tajik AJ. Cardiac surgery in the octogenarian: perioperative outcome and clinical follow-up. J Am Coll Cardiol. 1991 Jul; 18(1):29-35.
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  210. Cascino GD, Jack CR, Parisi JE, Sharbrough FW, Hirschorn KA, Meyer FB, Marsh WR, O'Brien PC. Magnetic resonance imaging-based volume studies in temporal lobe epilepsy: pathological correlations. Ann Neurol. 1991 Jul; 30(1):31-6.
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  211. Dyck PJ, Kratz KM, Lehman KA, Karnes JL, Melton LJ 3rd, O'Brien PC, Litchy WJ, Windebank AJ, Smith BE, Low PA. The Rochester Diabetic Neuropathy Study: design, criteria for types of neuropathy, selection bias, and reproducibility of neuropathic tests. Neurology. 1991 Jun; 41(6):799-807.
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  212. Stanhope CR, Wilson TO, Utz WJ, Smith LH, O'Brien PC. Suture entrapment and secondary ureteral obstruction. American Journal of Obstetrics & Gynecology. 1991 Jun; 164(6 Pt 1):1513-7; discussion 1517-9.
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  213. Gustavson CR, Gustavson JC, Noller KL, O'Brien PC, Melton LJ, Pumariega AJ, Kaufman RH, Colton T. Increased risk of profound weight loss among women exposed to diethylstilbestrol in utero. Behavioral & Neural Biology. 1991 May; 55(3):307-12.
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  214. Armon C, Kurland LT, O'Brien PC, Mulder DW. Antecedent medical diseases in patients with amyotrophic lateral sclerosis. Arch Neurol. 1991 Mar; 48:283-286.
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  215. Miller AR, van Heerden JA, Naessens JM, O'Brien PC. Simultaneous bilateral hernia repair. A case against conventional wisdom. Ann Surg. 1991 Mar; 213(3):272-6.
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  216. Lavine L, Steele JC, Wolfe N, Calne DB, O'Brien PC, Williams DB, Kurland LT, Schoenberg BS. Amyotrophic lateral sclerosis/parkinsonism-dementia complex in southern Guam: is it disappearing? Adv Neurol. 1991; 56:271-85.
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  217. O'Brien PC. Commentary in: Multiple comparisons in over-the-counter drug clinical trials with both positive and placebo controls, by D'Agostino and Herren Stat in Med. 1991; 10:9-12.
  218. Grambsch PM, O'Brien PC. The effects of preliminary tests for non-linearity in regression Stat in Med. 1991; 10:697-710.
  219. Freeman SL, O'Brien PC, Rizza RA. Use of human ultralente as the basal insulin component in treatment of patients with IDDM Diabetes Res and Clin Pracice. 1991; 12:187-92.
  220. Armon C, Kurland LT, Beard CM, O'Brien PC, et al Psychological and adaptational difficulties anteceding amyotrophic lateral sclerosis: Rochester, Minnesota, 1925-1987 Neuroepidemiology. 1991; 10:132-7.
  221. O'Brien PC, Tilley B, Meier P, et al. Selection bias in observational studies: An example from the Diethylstilbestrol Project Clin Practice of Gyn. 1991; 2:109-25.
  222. Davis KP, Stanhope CR, Garton GR, Atkinson EJ, O'Brien PC. Invasive vaginal carcinoma: Analysis of early-stage disease. Gynecol Oncol. 1991; 42:131-6.
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  223. Safranek TJ, Lawrence DN, Kurland LT, Culver DH, Wiederholt WC, Hayner NS, Osterholm MT, O'Brien P, Hughes JM. Measurement of the association between Guillian-Barré syndrome and receipt of swine influenza vaccine in 1976-1977: Results of a two-state study. American Journal of Epidemiology 133-***********.
  224. Khosla S, Johansen KL, Ory SJ, O'Brien PC, Kao PC. Parathyroid hormone-related peptide in lactation and in umbilical cord blood. Mayo Clin Proc. 1990 Nov; 65(11):1408-14.
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  225. Dyck PJ, Karnes JL, Gillen DA, O'Brien PC, Zimmerman IR, Johnson DM. Comparison of algorithms of testing for use in automated evaluation of sensation. Neurology. 1990 Oct; 40(10):1607-13.
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  226. Popescu NA, Beard CM, Treacy PJ, Winkelmann RK, O'Brien PC, Kurland LT. Cutaneous malignant melanoma in Rochester, Minnesota: trends in incidence and survivorship, 1950 through 1985. Mayo Clin Proc. 1990 Oct; 65(10):1293-302.
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  227. Rakela J, Wood JR, Czaja AJ, O'Brien PC, Taswell HF, Bowyer BA, Lange SM, Anderson ML, Parent K. Long-term versus short-term treatment with recombinant interferon alfa-2a in patients with chronic hepatitis B: a prospective, randomized treatment trial. Mayo Clin Proc. 1990 Oct; 65(10):1330-5.
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  228. Johnson WJ, Kyle RA, Pineda AA, O'Brien PC, Holley KE. Treatment of renal failure associated with multiple myeloma. Plasmapheresis, hemodialysis, and chemotherapy. Arch Intern Med. 1990 Apr; 150(4):863-9.
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  229. Wilson TO, Podratz KC, Gaffey TA, Malkasian GD, O'Brien PC, Naessens JM. Evaluation of unfavorable histologic subtypes in endometrial adenocarcinoma. American Journal of Obstetrics & Gynecology. 1990 Feb; 162(2):418-23; discussion 423-6.
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  230. Ingall TJ, McLeod JG, O'Brien PC. The effect of aging on autonomic nervous system function Aust NZ J Med. 1990; 20:570-7.
  231. McMahon MM, O'Brien PC, Service FJ. Diagnostic interpretation of the intravenous tolbutamide test for insulinoma. Mayo Clin Proc. 1989 Dec; 64(12):1481-8.
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  232. Dyck PJ, O'Brien PC. Meaningful degrees of prevention or improvement of nerve conduction in controlled clinical trials of diabetic neuropathy. Diabetes Care. 1989 Oct; 12(9):649-52.
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  233. Nielsen SN, Podratz KC, Scheithauer BW, O'Brien PC. Clinicopathologic analysis of uterine malignant mixed mullerian tumors. Gynecol Oncol. 1989 Sep; 34(3):372-8.
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  234. Davis LJ, de la Fuente JR, Morse RM, Landa E, O'Brien PC. Self-administered alcoholism screening test (SAAST): comparison of classificatory accuracy in two cultures. Alcoholism: Clinical & Experimental Research. 1989 Apr; 13(2):224-8.
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  235. O'Brien PC, Shampo MA, Dyck PJ. Statistical analysis in clinical laboratory medicine: fundamentals and common uses. Crit Rev Clin Lab Sci. 1989; 27(4):319-40.
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  236. Dyck PJ, Minnerath SR, O'Brien PC. Nerve glucose, sorbitol, fructose, and myo-inositol at various times after feeding in streptozotocin-induced diabetes in rats. Mayo Clin Proc. 1989; 64:905-910.
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  237. O'Brien PC. Discussion in: Interim analyses: The repeated confidence interval approach by Jennison and Turnbull. J Royal Statistical Soc. 1989; 51:349.


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