Publications - Stephen Brimijoin, Ph.D.

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  1. Anker JJ, Brimijoin S, Gao Y, Geng L, Zlebnik NE, Parks RJ, Carroll ME. Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months. Biol Psychiatry. 2012 Apr 15; 71(8):700-5. Epub 2011 Dec 30.
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  2. Seo S, Lomberk G, Mathison A, Buttar N, Podratz J, Calvo E, Iovanna J, Brimijoin S, Windebank A, Urrutia R. Kruppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells. J Biol Chem. 2012 Apr 13; 287(16):12723-35. Epub 2012 Feb 28.
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  3. Pang YP, Brimijoin S, Ragsdale DW, Zhu KY, Suranyi R. Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides. Curr Drug Targets. 2012 Apr; 13(4):471-82.
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  4. Brimijoin S, Gao Y. Cocaine hydrolase gene therapy for cocaine abuse. Future Med Chem. 2012 Feb; 4(2):151-62.
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  5. Brimijoin S. Interception of cocaine by enzyme or antibody delivered with viral gene transfer: a novel strategy for preventing relapse in recovering drug users. CNS Neurol Disord Drug Targets. 2011 Dec; 10(8):880-91.
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  6. Carroll ME, Gao Y, Brimijoin S, Anker JJ. Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats. Psychopharmacology (Berl). 2011 Feb; 213(4):817-29.
  7. Polsinelli GA, Singh SK, Mishra RK, Suranyi R, Ragsdale DW, Pang YP, Brimijoin S. Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle. Chem Biol Interact. 2010 Sep 6; 187(1-3):142-7. Epub 2010 Jan 28.
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  8. Gao Y, Orson FM, Kinsey B, Kosten T, Brimijoin S. The concept of pharmacologic cocaine interception as a treatment for drug abuse. Chem Biol Interact. 2010 Sep 6; 187(1-3):421-4. Epub 2010 Feb 26.
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  9. Gao Y, Brimijoin S. Lasting reduction of cocaine action in neostriatum--a hydrolase gene therapy approach. J Pharmacol Exp Ther. 2009 Aug; 330(2):449-57. Epub 2009 May 28.
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  10. Ray A, Liu J, Karanth S, Gao Y, Brimijoin S, Pope C. Cholinesterase inhibition and acetylcholine accumulation following intracerebral administration of paraoxon in rats. Toxicol Appl Pharmacol. 2009 May 1; 236(3):341-7. Epub 2009 Mar 06.
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  11. Tang H, Pavel J, Saavedra JM, Brimijoin S. Type-1 angiotensin receptors are expressed and transported in motor and sensory axons of rat sciatic nerves. Neuropeptides. 2009 Apr; 43(2):81-92. Epub 2009 Feb 23.
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  12. Pang YP, Singh SK, Gao Y, Lassiter TL, Mishra RK, Zhu KY, Brimijoin S. Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides. PLoS One. 2009; 4(2):e4349. Epub 2009 Feb 04.
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  13. Pang YP, Ekstrom F, Polsinelli GA, Gao Y, Rana S, Hua DH, Andersson B, Andersson PO, Peng L, Singh SK, Mishra RK, Zhu KY, Fallon AM, Ragsdale DW, Brimijoin S. Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases. PLoS One. 2009; 4(8):e6851. Epub 2009 Aug 28.
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  14. Hu W, Gray NW, Brimijoin S. Amyloid-beta alters trafficking of internalized acetylcholinesterase and dextran. International Journal of Physiology, Pathophysiology and Pharmacology. 2009; 1(1):15-24.
  15. Pavel J, Tang H, Brimijoin S, Moughamian A, Nishioku T, Benicky J, Saavedra JM. Expression and transport of Angiotensin II AT1 receptors in spinal cord, dorsal root ganglia and sciatic nerve of the rat. Brain Res. 2008 Dec 30; 1246:111-22. Epub 2008 Oct 17.
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  16. Brimijoin S, Gao Y, Anker JJ, Gliddon LA, Lafleur D, Shah R, Zhao Q, Singh M, Carroll ME. A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats. Neuropsychopharmacology. 2008 Oct; 33(11):2715-25. Epub 2008 Jan 16.
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  17. Gao Y, LaFleur D, Shah R, Zhao Q, Singh M, Brimijoin S. An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties. Chem Biol Interact. 2008 Sep 25; 175(1-3):83-7. Epub 2008 May 01.
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  18. Tang H, Pavel J, Saavedra JM, Brimijoin S. Angiotensin II type 1 receptors may not influence response of spinal autonomic neurons to axonal damage. Neurol Res. 2008 Sep; 30(7):751-60. Epub 2008 May 21.
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  19. Lassiter TL, Brimijoin S. Rats gain excess weight after developmental exposure to the organophosphorothionate pesticide, chlorpyrifos. Neurotoxicol Teratol. 2008 Mar-Apr; 30(2):125-30. Epub 2007 Nov 06.
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  20. Brimijoin S. Neuroscience in China. Cell Mol Neurobiol. 2008 Jan; 28(1):1-2. Epub 2007 Nov 14.
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  21. Garcia-Ayllon MS, Silveyra MX, Andreasen N, Brimijoin S, Blennow K, Saez-Valero J. Cerebrospinal fluid acetylcholinesterase changes after treatment with donepezil in patients with Alzheimer's disease. J Neurochem. 2007 Jun; 101(6):1701-11. Epub 2007 Feb 26.
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  22. Lassiter TL, Brimijoin S. A method to determine precise benchmark doses for carbamate anticholinesterases. Toxicol Sci. 2007 Mar; 96(1):154-61. Epub 2006 Dec 11.
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  23. Darreh-Shori T, Brimijoin S, Kadir A, Almkvist O, Nordberg A. Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism. Neurobiol Dis. 2006 Nov; 24(2):326-33. Epub 2006 Sep 14.
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  24. Gao Y, Brimijoin S. Viral transduction of cocaine hydrolase in brain reward centers. Cell Mol Neurobiol. 2006 Jul-Aug; 26(4-6):357-63. Epub 2006 May 18.
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  25. Gao Y, Brimijoin S. Visualizing viral transduction of a cocaine-hydrolyzing, human butyrylcholinesterase in rats. Chem Biol Interact. 2005 Dec 15; 157(Special Issue SI):97-103.
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  26. Rees TM, Berson A, Sklan EH, Younkin L, Younkin S, Brimijoin S, Soreq H. Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice. Curr Alzheimer Res. 2005 Jul; 2(3):291-300.
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  27. Brimijoin S. Can cholinesterase inhibitors affect neural development? Environ Toxicol Pharmacol. 2005 May; 19(3):429-32. Epub 2005 Feb 12.
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  28. Gao Y, Atanasova E, Sui N, Pancook JD, Watkins JD, Brimijoin S. Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats. Mol Pharmacol. 2005 Jan; 67(1):204-11.
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  29. Gao Y, Brimijoin S. An engineered cocaine hydrolase blunts and reverses cardiovascular responses to cocaine in rats. J Pharmacol Exp Ther. 2004 Sep; 310(3):1046-52.
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  30. Conti AM, Brimijoin S, Miller LJ, Windebank AJ. Suppression of neurite outgrowth by high-dose nerve growth factor is independent of functional p75NTR receptors. Neurobiol Dis. 2004 Feb; 15(1):106-14.
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  31. Hammond PI, Kern C, Hong F, Kollmeyer TM, Pang YP, Brimijoin S. Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design. J Pharmacol Exp Ther. 2003 Oct 1; 307(1):190-6.
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  32. Rees T, Hammond PI, Soreq H, Younkin S, Brimijoin S. Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex. Neurobiol Aging. 2003 Oct; 24(6):777-87.
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  33. Hu W, Gray NW, Brimijoin S. Amyloid-beta increases acetylcholinesterase expression in neuroblastoma cells by reducing enzyme degradation. J Neurochem. 2003 Jul; 86(2):470-8.
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  34. Pang YP, Kollmeyer TM, Hong F, Lee JC, Hammond PI, Haugabouk SP, Brimijoin S. Rational design of alkylene-linked bis-pyridiniumalidoximes as improved acetylcholinesterase reactivators. Chem Biol. 2003 Jun; 10(6):491-502.
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  35. Leelakusolvong S, Bharucha AE, Sarr MG, Hammond PI, Brimijoin S, Phillips SF. Effect of extrinsic denervation on muscarinic neurotransmission in the canine ileocolonic region. Neurogastroenterol Motil. 2003 Apr; 15(2):173-86.
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  36. Hammond PI, Craig TA, Kumar R, Brimijoin S. Regional and cellular distribution of DREAM in adult rat brain consistent with multiple sensory processing roles. Mol Brain Res. 2003 Mar 17; 111(1-2):104-10.
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  37. Rees TM, Brimijoin S. The role of acetylicholinesterase in the pathogenesis of Alzheimer's disease. Drugs of Today. 2003 Jan; 39(1):75-83.
  38. Zhang H, Brimijoin S, Tang X-C. Apoptosis by β-amyloid25-35 in acetylcholine-esterase-overexpressing neuroblastoma cells. Acta Pharmacol Sinica. 2003; 24:853-858.
  39. Brimijoin S, Shen ML, Sun H. Radiometric solvent-partitioning assay for screening cocaine hydrolases and measuring cocaine levels in milligram tissue samples. Anal Biochem. 2002 Oct 15; 309(2):200-5.
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  40. Tang H, Brimijoin S. Death of preganglionic sympathetic neurons after surgical or immunologic lesion of peripheral processes. Exp Neurol. 2002 Sep; 177(1):105-14.
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  41. Sun H, Pang YP, Lockridge O, Brimijoin S. Re-engineering butyrylcholinesterase as a cocaine hydrolase. Mol Pharmacol. 2002 Aug; 62(2):220-4.
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  42. Sun H, Shen ML, Pang YP, Lockridge O, Brimijoin S. Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase. J Pharmacol Exp Ther. 2002 Aug; 302(2):710-6.
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  43. Tang H, Brimijoin S. Complement regulatory proteins and selective vulnerability of neurons to lysis on exposure to acetylcholinesterase antibody. J Neuroimmunol. 2001 Apr 2; 115(1-2):53-63.
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  44. Sun H, El Yazal J, Lockridge O, Schopfer LM, Brimijoin S, Pang YP. Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication. J Biol Chem. 2001 Mar 23; 276(12):9330-6. Epub 2000 Dec 4
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  45. Sharma KV, Brimijoin S, Koenigsberger C, Bigbee J. Acetylcholinesterase modulates the adhesion of neuroblastoma cells. J Neurosci Res , 2001; 63:165-175.
  46. Li B, Stribley JA, Ticu A, Xie W, Schopfer LM, Hammond P, Brimijoin S, Hinrichs S, Lockridge O. Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse. J. Neurochem. 2001; 75:1320-1331.
  47. Atanasova E, Chiappa S, Wieben E, Brimijoin S. Novel messenger RNA and alternative promoter for murine acetylcholinesterase. J Biol Chem. 1999 Jul 23; 274(30):21078-84.
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  48. Tang H, Miller SM, Ermilov LG, Lennon VA, Brimijoin S. Complement-mediated lesion of sympathetic ganglia in vitro with acetylcholinesterase antibodies. J Neuroimmunol. 1999 Jun 1; 97(1-2):86-93.
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  49. Veenstra TD, Prufer K, Koenigsberger C, Brimijoin SW, Grande JP, Kumar R. 1,25-Dihydroxyvitamin D3 receptors in the central nervous system of the rat embryo. Brain Res. 1998 Sep 7; 804(2):193-205.
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  50. Pang YP, Brimijoin S. Supercomputing-based dimeric analog approach for drug optimization. Parallel Comput. 1998 Sep; 24(9-10):1557-1566.
  51. Tang H, Hammond P, Brimijoin S. Acetylcholinesterase immunolesioning: regional vulnerability of preganglionic sympathetic neurons in rat spinal cord. Exp Neurol. 1998 Aug; 152(2):167-76.
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  52. Koenigsberger C, Hammond P, Brimijoin S. Developmental expression of acetyl- and butyrylcholinesterase in the rat: enzyme and mRNA levels in embryonic dorsal root ganglia. Brain Res. 1998 Mar 23; 787(2):248-58.
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  53. Mortensen SR, Brimijoin S, Hooper MJ, Padilla S. Comparison of the in vitro sensitivity of rat acetylcholinesterase to chlorpyrifos-oxon: what do tissue IC50 values represent? Toxicol Appl Pharmacol. 1998 Jan; 148(1):46-9.
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  54. Miller SM, Ermilov LG, Szurszewski JH, Hammond PI, Brimijoin S. Selective disruption of neurotransmission by acetylcholinesterase antibodies in sympathetic ganglia examined with intracellular microelectrodes. J Auton Nerv Syst. 1997 Dec 11; 67(3):156-67.
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  55. Koenigsberger C, Chiappa S, Brimijoin S. Neurite differentiation is modulated in neuroblastoma cells engineered for altered acetylcholinesterase expression. J Neurochem. 1997 Oct; 69(4):1389-97.
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  56. Veenstra TD, Londowski JM, Windebank AJ, Brimijoin S, Kumar R. Effects of 1,25-dihydroxyvitamin D3 on growth of mouse neuroblastoma cells. Brain Res Dev Brain Res. 1997 Mar 17; 99(1):53-60.
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  57. Pang YP, Hong F, Quiram P, Jelacic T, Brimijoin S. Synthesis of alkylene linked bis-THA and alkylene linked benzyl-THA as highly potent and selective inhibitors and molecular probes of acetylcholinesterase. J Chem Soc Perkin Trans. 1997 Jan 21(2):171-6.
  58. Holgert H, Holmberg K, Hannibal J, Fahrenkrug J, Brimijoin S, Hartman BK, Hokfelt T. PACAP in the adrenal gland--relationship with choline acetyltransferase, enkephalin and chromaffin cells and effects of immunological sympathectomy. Neuroreport. 1996 Dec 20; 8(1):297-301.
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  59. Holgert H, Lagercrantz H, Dagerlind A, Hartman BK, Cozzari C, Brimijoin S, Hokfelt T. Effects of immunological sympathectomy on postnatal peptide expression in the rat adrenal medulla. Brain Res Dev Brain Res. 1996 Nov 22; 97(1):88-95.
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  60. Hammond PI, Jelacic T, Padilla S, Brimijoin S. Quantitative, video-based histochemistry to measure regional effects of anticholinesterase pesticides in rat brain. Anal Biochem. 1996 Oct 1; 241(1):82-92.
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  61. Pang YP, Quiram P, Jelacic T, Hong F, Brimijoin S. Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease. J Biol Chem. 1996 Sep 27; 271(39):23646-9.
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  62. Wilson BW, Padilla S, Henderson JD, Brimijoin S, Dass PD, Elliot G, Jaeger B, Lanz D, Pearson R, Spies R. Factors in standardizing automated cholinesterase assays. J Toxicol Environ Health. 1996 Jun 7; 48(2):187-95.
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  63. McKinzie S, Tyce GM, Brimijoin S. Lowered norepinephrine turnover as a sign of impaired ganglionic transmission after preganglionic lesioning by acetylcholinesterase antibodies. J Pharmacol Exp Ther. 1996 May; 277(2):817-22.
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  64. Carmichael SW, Brimijoin WS. Looking at slow axonal transport. Microscopy Today. 1996; 96(9):3.
  65. Brimijoin S, Hammond P. Transient expression of acetylcholinesterase mRNA and enzyme activity in developing rat thalamus studied by quantitative histochemistry and in situ hybridization. Neurosci. 1996; 71:555-565.
  66. Holgert H, Åman K, Cozzari C, Hartman BK, Brimijoin S, Emson P, Goldstein M, Hökfelt T. The cholinergic innervation of the adrenal gland and its relation to enkephalin and nitric oxide synthase. Neuroreport. 1995 Dec 15; 6(18):2576-80.
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  67. Brimijoin WS. Using antibodies to unwire the sympathetic nervous system. News Physiol Sci. 1995 Jun; 10:101-106.
  68. Bruss M, Hammermann R, Brimijoin S, Bonisch H. Antipeptide antibodies confirm the topology of the human norepinephrine transporter. J Biol Chem. 1995 Apr 21; 270(16):9197-201.
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  69. Russell JW, Windebank AJ, McNiven MA, Brat DJ, Brimijoin WS. Effect of cisplatin and ACTH (4-9) on neural transport in cisplatin induced neurotoxicity. Brain Res. 1995 Apr 10; 676:258-67.
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  70. Li W, Ochalski PA, Brimijoin S, Jordan LM, Nagy JI. C-terminals on motoneurons: electron microscope localization of cholinergic markers in adult rats and antibody-induced depletion in neonates. Neuroscience. 1995 Apr; 65(3):879-91.
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  71. Chiappa S, Padilla S, Koenigsberger C, Moser V, Brimijoin S. Slow accumulation of acetylcholinesterase in rat brain during enzyme inhibition by repeated dosing with chlorpyrifos. Biochem Pharmacol. 1995 Mar 30; 49(7):955-63.
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  72. Brimijoin S, Dagerlind A, Rao R, McKinzie S, Hammond P. Accumulation of enkephalin, proenkephalin mRNA, and neuropeptide Y in immunologically denervated rat adrenal glands: evidence for divergent peptide regulation. J Neurochem. 1995 Mar; 64(3):1281-7.
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  73. Rao R, Brimijoin S. Reverse transcriptase-polymerase chain reaction assay for acetylcholinesterase mRNA in rat brain. Neurochem Res. 1995 Feb; 20(2):129-35.
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  74. Hammond P, Rao R, Koenigsberger C, Brimijoin S. Regional variation in expression of acetylcholinesterase mRNA in adult rat brain analyzed by in situ hybridization. Proc Natl Acad Sci U S A. 1994 Nov 8; 91(23):10933-7.
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  75. Dagerlind A, Pelto-Huikko M, Lundberg JM, Ubink R, Verhofstad A, Brimijoin S, Hokfelt T. Immunologically induced sympathectomy of preganglionic nerves by antibodies against acetylcholinesterase: increased levels of peptides and their messenger RNAs in rat adrenal chromaffin cells. Neuroscience. 1994 Sep; 62(1):217-39.
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  76. Mesulam MM, Brimijoin S, Geula C. Neurofibrillary tangles have no obligatory predilection for acetylcholinesterase-rich neurons. Neurobiol Aging. 1994 Sep-Oct; 15(5):615-9.
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  77. Brimijoin S, Hammond P, Khraibi AA, Tyce GM. Catecholamine release and excretion in rats with immunologically induced preganglionic sympathectomy. J Neurochem. 1994 Jun; 62(6):2195-204.
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  78. Dagerlind A, Zhang X, Brimijoin S, Lindh B, Hokfelt T. Effects of preganglionic sympathectomy on peptides in the rat superior cervical ganglion. Neuroreport. 1994 Apr 14; 5(8):909-12.
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  79. Brat DJ, Brimijoin S. Acrylamide and glycidamide impair neurite outgrowth in differentiating N1E.115 neuroblastoma without disturbing rapid bidirectional transport of organelles observed by video microscopy. J Neurochem. 1993 Jun; 60(6):2145-52.
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  80. Oka N, Brimijoin S. Altered spectrum of retrogradely transported axonal proteins in P-bromophylacetylurea neuropathy. Neurochem Res. 1993 Jun; 18:675-680.
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  81. Dagerlind A, Brimijoin S, Goldstein M, Hokfelt T. Effects of antibodies against acetylcholinesterase on the expression of peptides and catecholamine synthesizing enzymes in the rat adrenal gland. Neuroscience. 1993 Jun; 54:1079-1090.
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  82. Brimijoin S, Moser V, Hammond P, Oka N, Lennon VA. Death of intermediolateral spinal cord neurons follows selective, complement-mediated destruction of peripheral preganglionic sympathetic terminals by acetylcholinesterase antibodies. Neuroscience. 1993 May; 54(1):201-23.
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  83. Rakonczay Z, Hammond P, Brimijoin S. Lesion of central cholinergic systems by systemically administered acetylcholinesterase antibodies in newborn rats. Neuroscience. 1993 May; 54(1):225-38.
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  84. Brat DJ, Brimijoin S. A paradigm for examining toxicant effects on viability, structure, and axonal transport of neurons in culture. Mol Neurobiol. 1992 Summer-Fall; 6(2-3):125-35.
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  85. Brat DJ, Windebank AJ, Brimijoin S. Emulsifier for intravenous cyclosporin inhibits neurite outgrowth, causes deficits in rapid axonal transport and leads to structural abnormalities in differentiating N1E.115 neuroblastoma. J Pharmacol Exp Ther. 1992 May; 261(2):803-10.
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  86. Oka N, Brimijoin WS. Tubulomembranous lesions in para-bromophenylacetylurea neuropathy reflect local stasis of fast axonal transport: evidence from electron microscopic autoradiography. Mayo Clin Proc. 1992 Apr; 67(4):341-8.
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  87. Padilla S, Moser VC, Pope CN, Brimijoin WS. Paraoxon toxicity is not potentiated by prior reduction in blood acetylcholinesterase. Toxicol Appl Pharmacol. 1992; 117:110-115.
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  88. Bean AJ, Xu Z, Chai SY, Brimijoin S, Hokfelt T. Effect of intracerebral injection of monoclonal acetylcholinesterase antibodies on cholinergic nerve terminals in the rat central nervous system. Neurosci Lett. 1991 Nov 25; 133(1):145-9.
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  89. Mesulam MM, Geula C, Cosgrove R, Mash D, Brimijoin S. Immunocytochemical demonstration of axonal and perikaryl in human cerebral cortex. Brain Res. 1991 Jan 25; 539:233-238.
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  90. Brimijoin S, Lennon VA. Selective destruction of preganglionic sympathetic nerves by antibodies to acetylcholinesterase. J Neural Transm Suppl. 1991; 34:139-45.
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  91. Brimijoin S, Lennon VA. Autoimmune preganglionic sympathectomy induced by acetylcholinesterase antibodies. Proc Natl Acad Sci U S A. 1990 Dec; 87(24):9630-4.
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  92. Oka N, Brimijoin S. Premature onset of fast axonal transport in bromophenylacetylurea neuropathy: an electrophoretic analysis of proteins exported into motor nerve. Brain Res. 1990 Feb 12; 509(1):107-10.
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  93. Brimijoin S, Balm M, Hammond P, Lennon VA. Selective complexing of acetylcholinesterase in brain by intravenously administered monoclonal antibody. J Neurochem. 1990 Jan; 54(1):236-41.
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  94. Studelska DR, Brimijoin S. Partial isolation of two classes of DBH-containing particles undergoing rapid axonal transport in rat sciatic nerve. J Neurochem. 1989; 53:622-631.
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