Publications - Harvinder S. Luthra, M.D.

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  1. Behrens M, Smart M, Luckey D, Luthra H, Taneja V. To B or not to B: role of B cells in pathogenesis of arthritis in HLA transgenic mice. J Autoimmun. 2011 Sep; 37(2):95-103. Epub 2011 Jun 12.
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  2. Behrens M, Papadopoulos GK, Moustakas A, Smart M, Luthra H, David CS, Taneja V. Trans heterodimer between two non-arthritis-associated HLA alleles can predispose to arthritis in humanized mice. Arthritis Rheum. 2011 Jun; 63(6):1552-61.
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  3. Kermani TA, Crowson CS, Achenbach SJ, Luthra HS. Idiopathic retroperitoneal fibrosis: a retrospective review of clinical presentation, treatment, and outcomes. Mayo Clin Proc. 2011 Apr; 86(4):297-303.
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  4. Akkara Veetil BM, Luthra H. Erdheim-Chester disease. Clin Rheumatol. 2011 Mar; 30(3):397-8. Epub 2010 Oct 15.
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  5. Behrens M, Trejo T, Luthra H, Griffiths M, David CS, Taneja V. Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice. J Autoimmun. 2010 Aug; 35(1):1-9. Epub 2010 Jan 12.
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  6. Kumar N, Sandroni P, Steensma DP, Luthra HS, Habermann TM. Polyradiculopathy due to methotrexate-induced ebv-associated lymphoproliferative disorder. Neurology. 2008 Nov 11; 71(20):1644-5.
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  7. Taneja V, Behrens M, Basal E, Sparks J, Griffiths MM, Luthra H, David CS. Delineating the role of the HLA-DR4 "shared epitope" in susceptibility versus resistance to develop arthritis. J Immunol. 2008 Aug 15; 181(4):2869-77.
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  8. Kermani TA, Luthra HS. Folate supplementation and methotrexate in treatment of rheumatoid arthritis. Indian Journal of Rheumatology. 2008; 3(2):77-9.
  9. Chowdhary VR, Grande JP, Luthra HS, David CS. Characterization of haemorrhagic pulmonary capillaritis: another manifestation of Pristane-induced lupus. Rheumatology (Oxford). 2007 Sep; 46(9):1405-10. Epub 2007 Jun 18.
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  10. Taneja V, Krco CJ, Behrens MD, Luthra HS, Griffiths MM, David CS. B cells are important as antigen presenting cells for induction of MHC-restricted arthritis in transgenic mice. Mol Immunol. 2007 Apr; 44(11):2988-96. Epub 2007 Feb 14.
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  11. Taneja V, Behrens M, Mangalam A, Griffiths MM, Luthra HS, David CS. New humanized HLA-DR4-transgenic mice that mimic the sex bias of rheumatoid arthritis. Arthritis Rheum. 2007 Jan; 56(1):69-78.
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  12. Cauduro SA, Moder KG, Luthra HS, Seward JB. Echocardiographically guided pericardiocentesis for treatment of clinically significant pericardial effusion in rheumatoid arthritis. J Rheumatol. 2006 Nov; 33(11):2173-7.
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  13. Chowdhry V, Kumar N, Lachance DH, Salomao DR, Luthra HS. An unusual presentation of rheumatoid meningitis. J Neuroimaging. 2005 Jul; 15(3):286-8.
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  14. Taneja V, Taneja N, Behrens M, Griffiths MM, Luthra HS, David CS. Requirement for CD28 may not be absolute for collagen-induced arthritis: study with HLA-DQ8 transgenic mice. J Immunol. 2005 Jan 15; 174(2):1118-25.
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  15. Kent PD, Luthra HS, Michet CJ. Risk factors for methotrexate-induced abnormal laboratory monitoring results in patients with rheumatoid arthritis. J Rheumatol. 2004 Sep; 31(9):1727-31.
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  16. Kent PD, Michet CJ Jr, Luthra HS. Relapsing polychondritis. Curr Opin Rheumatol. 2004 Jan; 16(1):56-61.
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  17. Tripuraneni R, Houghton SG, Luthra HS, Grogg KL, vanHeerden JA. What can be done for a woman with ‘holes’ in her spleen? Contemporary Surgery. 2004; 60(9):418-22.
  18. Taneja V, Griffiths M, Behrens M, Luthra HS, David CS. Auricular chondritis in NOD.DQ8.Abetao (Ag7-/-) transgenic mice resembles human relapsing polychondritis. J Clin Invest. 2003 Dec; 112(12):1843-50.
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  19. Siegel JL, Luthra H, Donlinger J, Angulo P, Lindor K. Association of primary biliary cirrhosis and rheumatoid arthritis. J Clin Rheumatol. 2003 Dec; 9(6):340-3.
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  20. Taneja V, Taneja N, Behrens M, Pan S, Trejo T, Griffiths M, Luthra H, David CS. HLA-DRB1*0402 (DW10) transgene protects collagen-induced arthritis-susceptible H2Aq and DRB1*0401 (DW4) transgenic mice from arthritis. J Immunol. 2003 Oct 15; 171(8):4431-8.
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  21. Klos K, Flemming KD, Petty GW, Luthra HS. Takayasu's arteritis with arteriographic evidence of intracranial vessel involvement. Neurology. 2003 May 13; 60(9):1550-1.
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  22. Moder KG, Gaffey TA, Luthra HS. A smoker with a pulmonary nodule and progressive neurologic deficits... Wegener granulomatosis, fortieth in a series. J Musculoskeletal Med. 2003 May; 20(5):251-3.
  23. Bidaut-Russell M, Gabriel SE, Scott CG, Zinsmeister AR, Luthra HS, Yawn B. Determinants of patient satisfaction in chronic illness. Arthritis Rheum. 2002 Oct 15; 47(5):494-500.
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  24. Taneja V, Taneja N, Paisansinsup T, Behrens M, Griffiths M, Luthra H, David CS. CD4 and CD8 T cells in susceptibility/protection to collagen-induced arthritis in HLA-DQ8-transgenic mice: implications for rheumatoid arthritis. J Immunol. 2002 Jun 1; 168(11):5867-75.
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  25. Paisansinsup T, Deshmukh US, Chowdhary VR, Luthra HS, Fu SM, David CS. HLA class II influences the immune response and antibody diversification to Ro60/Sjogren's syndrome-A: Heightened antibody responses and epitope spreading in mice expressing HLA-DR molecules. J Immunol. 2002 Jun 1; 168(11):5876-84.
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  26. Paisansinsup T, Vallejo AN, Luthra H, David CS. HLA-DR modulates autoantibody repertoire, but not mortality, in a humanized mouse model of systemic lupus erythematosus. J Immunol. 2001 Oct 1; 167(7):4083-90.
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  27. Gabriel SE, Wagner JL, Zinsmeister AR, Scott CG, Luthra HS. Is rheumatoid arthritis care more costly when provided by rheumatologists compared with generalists? Arthritis Rheum. 2001 Jul; 44(7):1504-14.
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  28. Khare SD, Lee S, Bull MJ, Hanson J, Luthra HS, David CS. Spontaneous inflammatory disease in HLA-B27 transgenic mice does not require transporter of antigenic peptides. Clin Immunol. 2001 Mar; 98(3):364-9.
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  29. Wasserman SI, Kimball HR, Duffy FD, and for the Task Force on Recertification. Recertification in internal medicine: a program of continuous professional development. Ann Intern Med. 2000 Aug 1; 133(3):202-8.
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  30. Menke DM, Griesser H, Moder KG, Tefferi A, Luthra HS, Cohen MD, Colon-Otero G, Lloyd RV. Lymphomas in patients with connective tissue disease. Comparison of p53 protein expression and latent EBV infection in patients immunosuppressed and not immunosuppressed with methotrexate. Am J Clin Pathol. 2000 Feb; 113(2):212-8.
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  31. Lee S, Khare SD, Griffiths MM, Luthra HS, David CS. HLA-B27 transgenic mice are susceptible to collagen-induced arthritis: type II collagen as a potential target in human disease. Hum Immunol. 2000 Feb; 61(2):140-7.
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  32. Pan S, Taneja V, Griffiths MM, Luthra H, David CS. Complementation between HLA-DR4 (DRB1*0401) and specific H2-A molecule in transgenic mice leads to collagen-induced arthritis. Hum Immunol. 1999 Sep; 60(9):816-25.
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  33. Krco CJ, Watanabe S, Harders J, Griffths MM, Luthra H, David CS. Identification of T cell determinants on human type II collagen recognized by HLA-DQ8 and HLA-DQ6 transgenic mice. J Immunol. 1999 Aug 1; 163(3):1661-5.
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  34. Das P, Bradley DS, Geluk A, Griffiths MM, Luthra HS, David CS. An HLA-DRB1*0402 derived peptide (HV3 65-79) prevents collagen-induced arthritis in HLA-DQ8 transgenic mice. Hum Immunol. 1999 Jul; 60(7):575-82.
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  35. Gabriel SE, Crowson CS, Luthra HS, Wagner JL, O'Fallon WM. Modeling the lifetime costs of rheumatoid arthritis. J Rheumatol. 1999 Jun; 26(6):1269-74.
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  36. Khare SD, Lee S, Bull MJ, Hanson J, Luthra HS, Hammerling GJ, David CS. Peptide binding alpha1alpha2 domain of HLA-B27 contributes to the disease pathogenesis in transgenic mice. Hum Immunol. 1999 Feb; 60(2):116-26.
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  37. Bradley DS, Das P, Griffiths MM, Luthra HS, David CS. HLA-DQ6/8 double transgenic mice develop auricular chondritis following type II collagen immunization: a model for human relapsing polychondritis. J Immunol. 1998 Nov 1; 161(9):5046-53.
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  38. Khare SD, Luthra HS, David CS. Animal models of human leukocyte antigen B27-linked arthritides. Rheum Dis Clin North Am. 1998 Nov; 24(4):883-94, xi-xii.
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  39. Taneja V, Griffiths MM, Luthra H, David CS. Modulation of HLA-DQ-restricted collagen-induced arthritis by HLA-DRB1 polymorphism. Int Immunol. 1998 Oct; 10(10):1449-57.
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  40. Khare SD, Luthra HS, David CS. Unraveling the mystery of HLA-B27 association with human spondyloarthropathies using transgenic and knock out mice. Semin Immunol. 1998 Feb; 10(1):15-23.
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  41. Khare SD, Bull MJ, Hanson J, Luthra HS, David CS. Spontaneous inflammatory disease in HLA-B27 transgenic mice is independent of MHC class II molecules: a direct role for B27 heavy chains and not B27-derived peptides. J Immunol. 1998 Jan 1; 160(1):101-6.
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  42. Khare SD, Luthra HS, David CS. HLA-B27 and other predisposing factors in spondyloarthrapathies. Curr Opin Rheumatol. 1998; 10(4):282-291.
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  43. Bradley DS, Nabozny GH, Cheng S, Zhou P, Griffiths MM, Luthra HS, David CS. HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis. J Clin Invest. 1997 Nov 1; 100(9):2227-34.
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  44. Taneja V, Hansen J, Smart M, Griffiths M, Luthra H, David CS. Expression of the H2-E molecule mediates protection to collagen-induced arthritis in HLA-DQ8 transgenic mice: role of cytokines. Int Immunol. 1997 Aug; 9(8):1213-9.
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  45. Khare SD, Hansen J, Luthra HS, David CS. HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human beta2-microglobulin (beta2m) double transgenic mice with disrupted mouse beta2m. J Clin Invest. 1996 Dec 15; 98(12):2746-55.
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  46. Gonzalez-Gay MA, Zanelli E, Khare SD, Krco CJ, Zhou P, Inoko H, Griffiths MM, Luthra HS, David CS. Human leukocyte antigen-DRB1*1502 (DR2Dw12) transgene reduces incidence and severity of arthritis in mice. Hum Immunol. 1996 Sep 15; 50(1):54-60.
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  47. Krco CJ, Pawelski J, Harders J, McCormick D, Griffiths M, Luthra HS, David CS. Characterization of the antigenic structure of human type II collagen. J Immunol. 1996 Apr 15; 156(8):2761-8.
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  48. Nabozny GH, Baisch JM, Cheng S, Cosgrove D, Griffiths MM, Luthra HS, David CS. HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis. J Exp Med. 1996 Jan 1; 183(1):27-37.
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  49. Khare SD, Luthra HS, David CS. Role of HLA-B27 in spondyloarthropathies. Curr Top Microbiol Immunol. 1996; 206:85-100.
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  50. Gonzalezgay MA, Zanelli E, Khare SD, Krco CJ, Griffiths MM, Luthra HS, David CS. Polymorphism contributes to H2-E-beta-mediated protection in collagen-induced arthritis. Immunogenetics. 1996; 44(5):377-384.
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  51. Khare SD, Krco CJ, Griffiths MM, Luthra HS, David CS. Oral administration of an immunodominant human collagen peptide modulates collagen-induced arthritis. J Immunol. 1995 Oct 1; 155(7):3653-9.
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  52. Khare SD, Luthra HS, David CS. Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies. J Exp Med. 1995 Oct 1; 182(4):1153-8.
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  53. Moder KG, Gaffey TA, Luthra HS. Musculoskeletal radiology quiz. A smoker with a pulmonary nodule and progressive neurologic deficits. J Musculoskeletal Med. 1995 Oct; 12(10):71-2, 74.
  54. Moder KG, Tefferi A, Cohen MD, Menke DM, Luthra HS. Hematologic malignancies and the use of methotrexate in rheumatoid arthritis: a retrospective study. Am J Med. 1995 Sep; 99(3):276-81.
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  55. David CS, Nabozny GH, Gonzalez-Gay M, Zanelli E, Griffiths M, Luthra H. Polymorphism in the HLA-DQ locus determines susceptibility and polymorphism in the HLA-DR beta 1 genes determine protection in collagen induced arthritis: implications in human rheumatoid arthritis. Ann Rheum Dis. 1995 Sep; 54(9):760-761.
  56. Nabozyny GH, Rimm IJ, Griffiths MM, Luthra HS, David CS. Expression of an ovalbumin-specific V(beta)8.2 TCR transgene inhibits collagen arthritis in B10.Q mice. Int Immunol. 1995 Aug; 7:1279-1286.
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  57. Nabozny GH, Griffiths MM, Rimm IJ, Luthra HS, David CS. Effect of constrained T-cell receptor repertoires on collagen-induced arthritis in T-cell receptor V beta transgenic and congenic mice. Ann N Y Acad Sci. 1995 Jul 7; (756):217-20.
  58. Nabozny GH, Hanson J, Griffiths MM, Luthra HS, David CS. Altered development of collagen induced arthritis in T cell receptor V beta congenic B10.RIII mice. Autoimmunity. 1995; 20(1):51-8.
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  59. Nabozny GH, Griffiths MM, Harper DS, Luthra HS, David CS. Identification of a cyanogen bromide fragment of porcine type II collagen capable of modulating collagen arthritis in B10.RIII (H-2r) mice. Autoimmunity. 1995; 20(1):39-49.
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  60. Gonzalez-Gay MA, Zanelli E, Krco CJ, Nabozny GH, Hanson J, Griffiths MM, Luthra HS, David CS. Polymorphism of the MHC class II Eb gene determines the protection against collagen-induced arthritis. Immunogenetics. 1995; 42(1):35-40.
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  61. Gonzalez-Gay MA, Nabozny GH, Bull MJ, Zanelli E, Douhan J 3rd, Griffiths MM, Glimcher LH, Luthra HS, David CS. Protective role of major histocompatibility complex class II Ebd transgene on collagen-induced arthritis. J Exp Med. 1994 Oct 1; 180(4):1559-64.
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  62. Griffiths MM, Nabozny GH, Hanson J, Harper DS, McCall S, Moder KG, Cannon GW, Luthra HS, David CS. Collagen-induced arthritis and TCRs in SWR and B10.Q mice expressing an e (alpha) (k) transgene. J Immunol. 1994 Sep 15; 153:2758-2768.
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  63. Nabozny GH, Bull MJ, Hanson J, Griffiths MM, Luthra HS, David CS. Collagen-induced arthritis in T cell receptor V beta congenic B10.Q mice. J Exp Med. 1994 Aug 1; 180(2):517-24.
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  64. Rhee RY, Gloviczki P, Luthra HS, Stanson AW, Bower TC, Cherry KJ Jr. Iliocaval complication of retroperitoneal fibrosis. Am J Surg. 1994 Aug; 168:179-183.
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  65. Gonzalez-Gay MA, Luthra HS, David CS. Collagen-induced arthritis: an experimental model for rheumatoid arthritis. [Spanish]. Rev Esp Reumatol. 1994; 21(8):329-333.
  66. Moder KG, Luthra HS, Griffiths M, David CS. Prevention of collagen induced arthritis in mice by deletion of T cell receptor V beta 8 bearing T cells with monoclonal antibodies. Br J Rheumatol. 1993 Jan; 32(1):26-30.
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  67. Griffiths MM, Cole BC, Ito J, Harper DS, Anderson GD, Cannon GW, Luthra HS, David CS. T-cell receptors and collagen induced arthritis in H-2r mice. Autoimmunity. 1993; 14(3):221-9.
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  68. Moder KG, Nabozny GH, Luthra HS, David CS. Immunogenetics of collagen induced arthritis in mice: a model for human polyarthritis. Reg Immunol. 1992 Sep-Oct; 4(5):305-13.
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  69. Luthra HS. Newer modalities in the treatment of rheumatoid arthritis. The Practice of Internal Medicine-1992 1992 May 11-15; 319-20.
  70. Moder KG, Luthra HS, Kubo R, Griffiths M, David CS. Prevention of collagen induced arthritis in mice by treatment with an antibody directed against the T cell receptor alpha beta framework. Autoimmunity. 1992; 11(4):219-24.
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  71. Anderson GD, Banerjee S, Luthra HS, David CS. Role of Mls-1 locus and clonal deletion of T cells in susceptibility to collagen-induced arthritis in mice. J Immunol. 1991 Aug 15; 147(4):1189-93.
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  72. Nickerson C, Luthra H, David C. Antigenic mimicry and autoimmune diseases. Int Rev Immunol. 1991; 7(3):205-24.
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  73. Luthra HS. Rheumatoid arthritis. Clinical Immunology Newsletter. 1990 Sep; 10:127-128.
  74. Luthra HS, David CS. Collagen-induced arthritis in mice: a model for human rheumatoid arthritis? Clinical Immunology Newsletter. 1990 Sep; 10:131-136.
  75. Nickerson CL, Luthra HS, Savarirayan S, David CS. Susceptibility of HLA-B27 transgenic mice to Yersinia enterocolitica infection. Hum Immunol. 1990 Aug; 28(4):382-96.
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  76. Nickerson CL, Luthra HS, David CS. Role of enterobacteria and HLA-B27 in spondyloarthropathies: studies with transgenic mice. Ann Rheum Dis. 1990 Jun; 49(1):426-33.
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  77. Gabriel SE, Conn DL, Luthra H. Rifampin therapy in rheumatoid arthritis. J Rheumatol. 1990 Feb; 17(2):163-6.
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  78. Luthra HS, David CS. Collagen induced arthritis in mice: a model for human rheumatoid arthritis? Clinical Immunology Newsletter. 1990; 10:131-136.
  79. Nickerson CL, Hogen KL, Luthra HS, David CS. Effect of H-2 genes on expression of HLA-B27 and Yersinia-induced arthritis. Scand J Rheumatol Suppl. 1990; 87:85-90, discussion 90.
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  80. Banerjee S, Anderson GD, Luthra HS, David CS. Influence of complement C5 and VB T cell receptor mutations on susceptibility to collagen-induced arthritis in mice. J Immunol. 1989 Apr 1; 142:2237-2243.
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  81. Haqqi TM, Banerjee S, Jones WL, Anderson GD, Behlke MA, Loh DY, Luthra HS, David CS. Identification of T-cell receptor VB deletion mutant mouse strain AU/SSJ (H-2Q) which is resistant to collagen-induced arthritis. Immunogenetics. 1989 Mar; 29:180-185.
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  82. Valente RM, Luthra HS, Robb RA. Quantitative analysis of joint images from patients with rheumatoid arthritis. Proceedings of the IEEE. 1989; 11:1971-1972.


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