Publications - Joseph F. Poduslo, Ph.D.

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  1. Poduslo JF, Howell KG, Olson NC, Ramirez-Alvarado M, Kandimalla KK. Alzheimer's disease amyloid beta-protein mutations and deletions that define neuronal binding/internalization as early stage nonfibrillar/fibrillar aggregates and late stage fibrils. Biochemistry. 2012 May 15; 51(19):3993-4003. Epub 2012 May 07.
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  2. Murphy MC, Curran GL, Glaser KJ, Rossman PJ, Huston J 3rd, Poduslo JF, Jack CR Jr, Felmlee JP, Ehman RL. Magnetic resonance elastography of the brain in a mouse model of Alzheimer's disease: initial results. Magn Reson Imaging. 2012 May; 30(4):535-9. Epub 2012 Feb 10.
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  3. Jaruszewski KM, Ramakrishnan S, Poduslo JF, Kandimalla KK. Chitosan enhances the stability and targeting of immuno-nanovehicles to cerebro-vascular deposits of Alzheimer's disease amyloid protein. Nanomedicine. 2012 Feb; 8(2):250-60. Epub 2011 Jun 24.
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  4. Trushina E, Nemutlu E, Zhang S, Christensen T, Camp J, Mesa J, Siddiqui A, Tamura Y, Sesaki H, Wengenack TM, Dzeja PP, Poduslo JF. Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. PLoS One. 2012; 7(2):e32737. Epub 2012 Feb 29.
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  5. Omtri RS, Davidson MW, Arumugam B, Poduslo JF, Kandimalla KK. Differences in the cellular uptake and intracellular itineraries of amyloid beta proteins 40 and 42: Ramifications for the Alzheimer's drug discovery. Molecular Pharmaceutics. 2012; 9(7):1887-97.
  6. Poduslo JF, Hultman KL, Curran GL, Preboske GM, Chamberlain R, Marjanska M, Garwood M, Jack CR Jr, Wengenack TM. Targeting vascular amyloid in arterioles of Alzheimer disease transgenic mice with amyloid beta protein antibody-coated nanoparticles. J Neuropathol Exp Neurol. 2011 Aug; 70(8):653-61.
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  7. Chamberlain R, Wengenack TM, Poduslo JF, Garwood M, Jack CR Jr. Magnetic resonance imaging of amyloid plaques in transgenic mouse models of Alzheimer's disease. Curr Med Imaging Rev. 2011 Feb; 7(1):3-7.
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  8. Wengenack TM, Reyes DA, Curran GL, Borowski BJ, Lin J, Preboske GM, Holasek SS, Gilles EJ, Chamberlain R, Marjanska M, Jack CR Jr, Garwood M, Poduslo JF. Regional differences in MRI detection of amyloid plaques in AD transgenic mouse brain. Neuroimage. 2011 Jan 1; 54(1):113-22. Epub 2010 Aug 20.
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  9. Sarkar G, Curran GL, Mahlum E, Decklever T, Wengenack TM, Blahnik A, Hoesley B, Lowe VJ, Poduslo JF, Jenkins RB. A carrier for non-covalent delivery of functional beta-galactosidase and antibodies against amyloid plaques and IgM to the brain. PLoS One. 2011; 6(12):e28881. Epub 2011 Dec 21.
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  10. Poduslo JF, Gilles EJ, Ramakrishnan M, Howell KG, Wengenack TM, Curran GL, Kandimalla KK. HH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neurons. PLoS One. 2010; 5(1):e8813. Epub 2010 Jan 21.
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  11. Ramakrishnan M, Kandimalla KK, Wengenack TM, Howell KG, Poduslo JF. Surface plasmon resonance binding kinetics of Alzheimer's disease amyloid beta peptide-capturing and plaque-binding monoclonal antibodies. Biochemistry. 2009 Nov 3; 48(43):10405-15.
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  12. Chamberlain R, Reyes D, Curran GL, Marjanska M, Wengenack TM, Poduslo JF, Garwood M, Jack CR Jr. Comparison of amyloid plaque contrast generated by T2-weighted, T2*-weighted, and susceptibility-weighted imaging methods in transgenic mouse models of Alzheimer's disease. Magn Reson Med. 2009 May; 61(5):1158-64.
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  13. Yao JK, Wengenack TM, Curran GL, Poduslo JF. Reduced membrane lipids in the cortex of Alzheimer's disease transgenic mice. Neurochem Res. 2009 Jan; 34(1):102-8. Epub 2008 Mar 29.
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  14. Kandimalla KK, Scott OG, Fulzele S, Davidson MW, Poduslo JF. Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein. PLoS One. 2009; 4(2):e4627. Epub 2009 Feb 27.
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  15. Agyare EK, Curran GL, Ramakrishnan M, Yu CC, Poduslo JF, Kandimalla KK. Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathy. Pharm Res. 2008 Nov; 25(11):2674-84. Epub 2008 Aug 20.
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  16. Ramakrishnan M, Wengenack TM, Kandimalla KK, Curran GL, Gilles EJ, Ramirez-Alvarado M, Lin J, Garwood M, Jack CR Jr, Poduslo JF. Selective contrast enhancement of individual Alzheimer's disease amyloid plaques using a polyamine and Gd-DOTA conjugated antibody fragment against fibrillar Abeta42 for magnetic resonance molecular imaging. Pharm Res. 2008 Aug; 25(8):1861-72. Epub 2008 Apr 29.
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  17. Wengenack TM, Jack CR Jr, Garwood M, Poduslo JF. MR microimaging of amyloid plaques in Alzheimer's disease transgenic mice. Eur J Nucl Med Mol Imaging. 2008 Mar; 35 Suppl 1:S82-8.
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  18. Kandimalla KK, Wengenack TM, Curran GL, Gilles EJ, Poduslo JF. Pharmacokinetics and amyloid plaque targeting ability of a novel peptide-based magnetic resonance contrast agent in wild-type and Alzheimer's disease transgenic mice. J Pharmacol Exp Ther. 2007 Aug; 322(2):541-9. Epub 2007 May 15.
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  19. Poduslo JF, Ramakrishnan M, Holasek SS, Ramirez-Alvarado M, Kandimalla KK, Gilles EJ, Curran GL, Wengenack TM. In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques. J Neurochem. 2007 Jul; 102(2):420-33.
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  20. Hartman TK, Wengenack TM, Poduslo JF, van Deursen JM. Mutant mice with small amounts of BubR1 display accelerated age-related gliosis. Neurobiol Aging. 2007 Jun; 28(6):921-7. Epub 2006 Jun 15.
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  21. Jack CR Jr, Marjanska M, Wengenack TM, Reyes DA, Curran GL, Lin J, Preboske GM, Poduslo JF, Garwood M. Magnetic resonance imaging of Alzheimer's pathology in the brains of living transgenic mice: a new tool in Alzheimer's disease research. Neuroscientist. 2007 Feb; 13(1):38-48.
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  22. Kandimalla KK, Curran GL, Holasek SS, Gilles EJ, Wengenack TM, Ramirez-Alvarado M, Poduslo JF. Physiological and biophysical factors that influence Alzheimer's disease amyloid plaque targeting of native and putrescine modified human amyloid beta40. J Pharmacol Exp Ther. 2006 Jul; 318(1):17-25. Epub 2006 Mar 24.
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  23. Jack CR Jr, Wengenack TM, Reyes DA, Garwood M, Curran GL, Borowski BJ, Lin J, Preboske GM, Holasek SS, Adriany G, Poduslo JF. In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice. J Neurosci. 2005 Oct 26; 25(43):10041-8.
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  24. Marjanska M, Curran GL, Wengenack TM, Henry PG, Bliss RL, Poduslo JF, Jack CR, Ugurbil K, Garwood M. Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11906-10.
  25. Kandimalla KK, Curran GL, Holasek SS, Gilles EJ, Wengenack TM, Poduslo JF. Pharmacokinetic analysis of the blood-brain barrier transport of 125I-amyloid beta protein 40 in wild-type and Alzheimer's disease transgenic mice (APP,PS1) and its implications for amyloid plaque formation. J Pharmacol Exp Ther. 2005 Jun; 313(3):1370-8. Epub 2005 Mar 02.
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  26. Holasek SS, Wengenack TM, Kandimalla KK, Montano C, Gregor DM, Curran GL, Poduslo JF. Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice. Brain Res. 2005 May 31; 1045(1-2):185-98. Epub 2005 Apr 25.
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  27. Jack CR Jr, Garwood M, Wengenack TM, Borowski B, Curran GL, Lin J, Adriany G, Grohn OH, Grimm R, Poduslo JF. In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent. Magn Reson Med. 2004 Dec; 52(6):1263-71.
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  28. Wengenack TM, Holasek SS, Montano CM, Gregor D, Curran GL, Poduslo JF. Activation of programmed cell death markers in ventral horn motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in a transgenic mouse model. Brain Res. 2004 Nov 19; 1027(1-2):73-86.
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  29. Poduslo JF, Curran GL, Peterson JA, McCormick DJ, Fauq AH, Khan MA, Wengenack TM. Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability, and in vivo targeting to Alzheimer's disease amyloid plaques. Biochemistry. 2004 May 25; 43(20):6064-75.
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  30. Poduslo JF, Wengenack TM, Curran GL, Wisniewski T, Sigurdsson EM, Macura SI, Borowski BJ, Jack CR Jr. Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging. Neurobiol Dis. 2002 Nov; 11(2):315-29.
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  31. Poduslo JF, Curran GL. Amyloid beta peptide as a vaccine for Alzheimer's disease involves receptor-mediated transport at the blood-brain barrier. Neuroreport. 2001 Oct 29; 12(15):3197-200.
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  32. Poduslo JF, Curran GL, Wengenack TM, Malester B, Duff K. Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2001 Aug; 8(4):555-67.
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  33. Poduslo JF, Whelan SL, Curran GL, Wengenack TM. Therapeutic benefit of polyamine-modified catalase as a scavenger of hydrogen peroxide and nitric oxide in familial amyotrophic lateral sclerosis transgenics. Ann Neurol. 2000 Dec; 48(6):943-7.
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  34. Wengenack TM, Curran GL, Poduslo JF. Targeting alzheimer amyloid plaques in vivo. Nat Biotechnol. 2000 Aug; 18(8):868-72.
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  35. Burguera B, Couce ME, Curran GL, Jensen MD, Lloyd RV, Cleary MP, Poduslo JF. Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats. Diabetes. 2000 Jul; 49(7):1219-23.
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  36. Wengenack TM, Whelan S, Curran GL, Duff KE, Poduslo JF. Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain. Neuroscience. 2000; 101(4):939-44.
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  37. Reinholz MM, Merkle CM, Poduslo JF. Therapeutic benefits of putrescine-modified catalase in a transgenic mouse model of familial amyotrophic lateral sclerosis. Exp Neurol. 1999 Sep; 159(1):204-16.
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  38. Reinholz MM, Haggard JJ, Curran GL, Poduslo JF. Plasma pharmacokinetics, nervous system biodistribution and biostability, and spinal cord permeability at the blood-brain barrier of putrescine- modified catalase in the adult rat. Exp Neurol. 1999 Sep; 159(1):191-203.
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  39. Poduslo JF, Curran GL, Kumar A, Frangione B, Soto C. Beta-sheet breaker peptide inhibitor of Alzheimer's amyloidogenesis with increased blood-brain barrier permeability and resistance to proteolytic degradation in plasma. J Neurobiol. 1999 Jun 5; 39(3):371-82.
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  40. Poduslo JF, Curran GL, Sanyal B, Selkoe DJ. Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier. Neurobiol Dis. 1999 Jun; 6(3):190-9.
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  41. Poduslo JF, Curran GL, Gill JS. Putrescine-modified nerve growth factor: bioactivity, plasma pharmacokinetics, blood-brain/nerve barrier permeability, and nervous system biodistribution. J Neurochem. 1998 Oct; 71(4):1651-60.
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  42. Walikonis RS, Poduslo JF. Activity of cyclic AMP phosphodiesterases and adenylyl cyclase in peripheral nerve after crush and permanent transection injuries. J Biol Chem. 1998 Apr 10; 273(15):9070-7.
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  43. Wengenack TM, Curran GL, Olson EE, Poduslo JF. Putrescine-modified catalase with preserved enzymatic activity exhibits increased permeability at the blood-nerve and blood-brain barriers. Brain Res. 1997 Aug 29; 767(1):128-35.
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  44. Wengenack TM, Curran GL, Poduslo JF. Postischemic, systemic administration of polyamine-modified superoxide dismutase reduces hippocampal CA1 neurodegeneration in rat global cerebral ischemia. Brain Res. 1997 Apr 18; 754(1-2):46-54.
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  45. Poduslo JF, Curran GL, Haggard JJ, Biere AL, Selkoe DJ. Permeability and residual plasma volume of human, Dutch variant, and rat amyloid beta-protein 1-40 at the blood-brain barrier. Neurobiol Dis. 1997; 4(1):27-34.
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  46. Poduslo JF, Curran GL. Increased permeability of superoxide dismutase at the blood-nerve and blood-brain barriers with retained enzymatic activity after covalent modification with the naturally occurring polyamine, putrescine. J Neurochem. 1996 Aug; 67(2):734-41.
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  47. Poduslo JF, Curran GL. Polyamine modification increases the permeability of proteins at the blood-nerve and blood-brain barriers. J Neurochem. 1996 Apr; 66(4):1599-609.
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  48. Poduslo JF, Curran GL. Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF. Brain Res Mol Brain Res. 1996 Mar; 36(2):280-6.
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  49. Poduslo JF, Walikonis RS, Domec MC, Berg CT, Holtz-Heppelmann CJ. The second messenger, cyclic AMP, is not sufficient for myelin gene induction in the peripheral nervous system. J Neurochem. 1995 Jul; 65(1):149-59.
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  50. Poduslo JF, Curran GL, Berg CT. Macromolecular permeability across the blood-nerve and blood-brain barriers. Proc Natl Acad Sci U S A. 1994 Jun 7; 91(12):5705-9.
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  51. Poduslo JF, Curran GL. Glycation increases the permeability of proteins across the blood-nerve and blood-brain barriers. Brain Res Mol Brain Res. 1994 Apr; 23(1-2):157-62.
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  52. Gupta SK, Pringle J, Poduslo JF, Mezei C. Induction of myelin genes during peripheral nerve remyelination requires a continuous signal from the ingrowing axon. J Neurosci Res. 1993 Jan; 34(1):14-23.
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  53. Low PA, Kihara M, Cameron N, Cotter M, Poduslo JF. Cause and effect of ischemia in chronic experimental diabetic neuropathy. Diabet Med. 1993; 10(Suppl 2):52S-55S.
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  54. Podratz JL, Windebank AJ, Poduslo JF. Dialyzer associated neurotoxicity due to a change in fatty acid structure. Trans Am Soc Neurochem. 1993; 24:229.
  55. LeBlanc AC, Pringle J, Lemieux J, Poduslo JF, Mezei C. Regulation of 2',3'-cyclic nucleotide phosphodiesterase gene expression in experimental peripheral neuropathies. Brain Res Mol Brain Res. 1992 Sep; 15(1-2):40-6.
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  56. Poduslo JF, Curran GL. Increased permeability across the blood-nerve barrier of albumin glycated in vitro and in vivo from patients with diabetic polyneuropathy. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2218-22.
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  57. LeBlanc AC, Windebank AJ, Poduslo JF. P0 gene expression in Schwann cells is modulated by an increase of cAMP which is dependent on the presence of axons. Brain Res Mol Brain Res. 1992 Jan; 12(1-3):31-8.
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  58. Kihara M, Schmelzer JD, Poduslo JF, Curran GL, Nickander KK, Low PA. Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6107-11.
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  59. Gupta SK, Pringle J, Poduslo JF, Mezei C. Levels of proteolipid protein mRNAs in peripheral nerve are not under stringent axonal control. J Neurochem. 1991 May; 56(5):1754-62.
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  60. Yoshikawa H, Dyck PJ, Poduslo JF, Giannini C. Polyglucosan body axonal enlargement increases myelin spiral length but not lamellar number. J Neurol Sci. 1990 Aug; 98(1):107-17.
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  61. LeBlanc AC, Poduslo JF. Axonal modulation of myelin gene expression in the peripheral nerve. J Neurosci Res. 1990 Jul; 26(3):317-26.
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  62. Weerasuriya A, Curran GL, Poduslo JF. Development changes in blood-nerve transfer of albumin and endoneurial albumin content in rat sciatic nerve. Brain Res. 1990 Jun 25; 521:40-46.
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  63. Brunden KR, Windebank AJ, Poduslo JF. Role of axons in the regulation of P0 biosynthesis by Schwann cells. J Neurosci Res. 1990 Jun; 26(2):135-43.
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  64. Kohriyama T, Yu RK, Berg CT, Poduslo JF. Sulfate incorporation into peripheral nerve endoneurial glycolipids after crush and permanent transection injury. J Neurosci Res. 1990 Jun; 26(2):144-8.
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  65. Weerasuriya A, Curran GL, Poduslo JF. Physiological changes in the sciatic nerve endoneurium of lead-intoxicated rats: a model of endoneurial homeostasis. Brain Res. 1990 May 28; 517(1-2):1-6.
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  66. Poduslo JF. Golgi sulfation of the oligosaccharide chain of P0 occurs in the presence of myelin assembly but not in its absence. J Biol Chem. 1990 Mar 5; 265(7):3719-25.
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  67. Yao JK, Windebank AJ, Poduslo JF, Yoshino JE. Axonal regulation of Schwann cell glycolipid biosynthesis. Neurochem Res. 1990 Mar; 15(3):279-82.
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  68. Brunden KR, Windebank AJ, Poduslo JF. Catabolic regulation of the expression of the major myelin glycoprotein by Schwann cells in culture. J Neurochem. 1990 Feb; 54(2):459-66.
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  69. LeBlanc AC, Poduslo JF. Regulation of apolipoprotein E gene expression after injury of the rat sciatic nerve. J Neurosci Res. 1990 Feb; 25(2):162-71.
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  70. Gupta SK, Poduslo JF, Dunn R, Roder J, Mezei C. Myelin-associated glycoprotein gene expression in the presence and absence of Schwann cell-axonal contact. Dev Neurosci. 1990; 12(1):22-33.
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  71. Brunden KR, Poduslo JF. Posttranslational degradation of the major myelin glycoprotein by Schwann cells in vivo and in vitro. Ann N Y Acad Sci. 1990; 605:230-9.
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  72. Weerasuriya A, Curran GL, Poduslo JF. Blood-nerve transfer of albumin and its implications for the endoneurial microenvironment. Brain Res. 1989 Aug 7; 494(1):114-21.
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  73. Costantino-Ceccarini E, Poduslo JF. Regulation of UDP-galactose: ceramide galactosyltransferase after crush and transection nerve injury. J Neurochem. 1989 Jul; 53:205-211.
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