Publications - James L. Rae, Ph.D.

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1. Mazzone A, Bernard CE, Strege PR, Beyder A, Galietta LJ, Pasricha PJ, Rae JL, Parkman HP, Linden DR, Szurszewski JH, Ordog T, Gibbons SJ, Farrugia G. Altered expression of Ano1 variants in human diabetic gastroparesis. J Biol Chem. 2011 Apr 15; 286(15):13393-403. Epub 2011 Feb 24.
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2. Beyder A, Rae JL, Bernard C, Strege PR, Sachs F, Farrugia G. Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel. J Physiol. 2010 Dec 15; 588(Pt 24):4969-85. Epub 2010 Nov 01.
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3. Saito YA, Strege PR, Tester DJ, Locke GR 3rd, Talley NJ, Bernard CE, Rae JL, Makielski JC, Ackerman MJ, Farrugia G. Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G211-8. Epub 2008 Dec 04.
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4. Goetz MP, Suman VJ, Couch FJ, Ames MM, Rae JM, Erlander MG, Ma XJ, Sgroi DC, Reynolds CA, Lingle WL, Weinshilboum RM, Flockhart DA, Desta Z, Perez EA, Ingle JN. Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance. Clin Cancer Res. 2008 Sep 15; 14(18):5864-8.
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5. Rae JL, Levis RA. Fabrication of patch pipets. Current Protocols in Neuroscience. 2004 May; Chapter 6(Suppl 26):Unit 6.3.
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6. Mathias RT, Rae JL. The lens: local transport and global transparency. Exp Eye Res. 2004 Mar; 78(3):689-98.
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7. Ou Y, Gibbons SJ, Miller SM, Strege PR, Rich A, Distad MA, Ackerman MJ, Rae JL, Szurszewski JH, Farrugia G. SCN5A is expressed in human jejunal circular smooth muscle cells. Neurogastroenterol Motil. 2002 Oct; 14(5):477-86.
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8. Lyford GL, Strege PR, Shepard A, Ou YJ, Ermilov L, Miller SM, Gibbons SJ, Rae JL, Szurszewski JH, Farrugia G. alpha(1C) (Ca(v)1.2) L-type calcium channel mediates mechanosensitive calcium regulation. Am J Physiol Cell Physiol. 2002 Sep; 283(3):C1001-8.
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9. Rae JL, Levis RA. Single-cell electroporation. Pflugers Arch. 2002 Feb; 443(4):664-70.
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10. Holm AN, Rich A, Miller SM, Strege P, Ou Y, Gibbons S, Sarr MG, Szurszewski JH, Rae JL, Farrugia G. Sodium current in human jejunal circular smooth muscle cells. Gastroenterology. 2002 Jan; 122(1):178-87.
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11. Rae JL. Electroporation of single cells. Axobits. 2002; 34:7-11.
12. Rae JL, Shepard AR. Kv3.3 potassium channels in lens epithelium and corneal endothelium. Exp Eye Res. 2000 Mar; 70(3):339-48.
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13. Rae JL, Shepard AR. Kir2.1 Potassium channels and corneal epithelia. Curr Eye Res. 2000 Feb; 20(2):144-52.
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14. Rae JL, Levis RL. An electrode coating elastomer to replace sylgard 184. Axobits. 2000; 29:6-7.
15. Farrugia G, Holm AN, Rich A, Sarr MG, Szurszewski JH, Rae JL. A mechanosensitive calcium channel in human intestinal smooth muscle cells. Gastroenterology. 1999 Oct; 117(4):900-5.
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16. Shepard AR, Rae JL. Electrically silent potassium channel subunits from human lens epithelium. Am J Physiol. 1999 Sep; 277(3 Pt 1):C412-24.
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17. Shepard AR, Rae JL. "Microprep" method for rapidly isolating plasmid DNAs for restriction enzyme analysis. Biotechniques. 1999 May; 26(5):868-70.
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18. Rich A, Farrugia G, Rae JL. Effects of melatonin on ionic currents in cultured ocular tissues. Am J Physiol. 1999 Apr; 276(4 Pt 1):C923-9.
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19. Shepard AR, Rae JL. Ion transporters and receptors in cDNA libraries from lens and cornea epithelia. Curr Eye Res. 1998 Jul; 17(7):708-19.
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20. Rae JL, Shepard AR. Molecular biology electrophysiology of calcium-activated potassium channels from lens epithelium. Curr Eye Res. 1998 Mar; 17(3):264-275.
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21. Rae JL, Shepard AR. Inwardly rectifying potassium channels in lens epithelium are from the IRK1 (Kir 2.1) family. Exp Eye Res. 1998 Mar; 66(3):347-59.
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22. Farrugia G, Miller SM, Rich A, Liu X, Maines MD, Rae JL, Szurszewski JH. Distribution of heme oxygenase and effects of exogenous carbon monoxide in canine jejunum. Am J Physiol. 1998 Feb; 274(2 Pt 1):G350-8.
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23. Rae JL, Shepard AR. Identification of potassium channels in human lens epithelium. Current Topics in Membranes. 1998; 45:69-104.
24. Levis Ra, Rae JL. Low noise patch clamp techniques. Methods in Enzumology. 1998; 293:218-66.
25. Shepard AR, Rae JL. Magnetic bead capture of cDNAs from double-stranded plasmid cDNA libraries. Nucleic Acids Res. 1997 Aug 1; 25(15):3183-5.
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26. Rich A, Bartling C, Farrugia G, Rae JL. Effects of PH on the potassium current in rabbit corneal epithelial cells. Am J Physiol Cell Physiol. 1997 Feb; 272(2):C 744-C 753.
27. Mathias RT, Rae JL, Baldo GJ. Physiological properties of the normal lens. Physiol Rev. 1997 Jan; 77(1):21-50.
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28. Rae JL, Shepard AR. Chapter 4 identification of potassium channels in human lens epithelium. Curr Top Membr Transp. 1997; 45(C):69-104.
29. Rae JL, Watsky MA. Ionic channels in corneal endothelium. Am J Physiol Cell Physiol. 1996 Apr; 39(4):C 975-C 989.
30. Rae JL, Bartling C, Rae J, Mathias RT. Dye transfer between cells of the lens. J Membr Biol. 1996 Mar; 150(1):89-103.
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31. Rae JL, Watsky M. Ion channels in corneal endothelium. Am J Physiol. 1996; 270:C975-89.
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32. Farrugia G, Rich A, Rae JL, Sarr MG, Szurszewski JH. Calcium currents in human and canine jejunal circular smooth muscle cells. Gastroenterology. 1995 Sep; 109(3):707-17.
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33. Rae JL, Rich A, Zamudio AC, Candia OA. Effect of Prozac on whole cell ionic currents in lens and corneal epithelia. Am J Physiol. 1995 Jul; 269(1 Pt 1):C250-6.
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34. Dewey J, Bartling C, Rae JL. A non-enzymatic method for lens decapsulation which leaves the epithelial cells attached to the fibers. Curr Eye Res. 1995 May; 14(5):357-62.
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35. Rich A, Rae JL. Calcium entry in rabbit corneal epithelial cells: evidence for a nonvoltage dependent pathway. J Membr Biol. 1995 Mar; 144(2):177-84.
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36. Rae JL. Outwardly rectifying potassium currents in lens epithelial cell membranes. Curr Eye Res. 1994 Sep; 13(9):679-86.
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37. Rich A, Farrugia G, Rae JL. Carbon monoxide stimulates a potassium-selective current in rabbit corneal epithelial cells. Am J Physiol. 1994 Aug; 267(2 Pt 1):C435-42.
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38. Farrugia G, Rae JL, Sarr MG, Szurszewski JH. Potassium current in circular smooth muscle of human jejunum activated by fenamates. Am J Physiol. 1993 Nov; 265(5 Pt 1):G873-9.
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39. Levis RA, Rae JL. The use of quartz patch pipettes for low noise single channel recording. Biophys J. 1993 Oct; 65(4):1666-77.
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40. Rae JL. Ion channels in ocular epithelia. Invest Ophthalmol Vis Sci. 1993 Aug; 34(9):2608-12.
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41. Farrugia G, Rae JL, Szurszewski JH. Characterization of an outward potassium current in canine jejunal circular smooth muscle and its activation by fenamates. J Physiol. 1993 Aug; 468:297-310.
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42. Watsky MA, Rae JL. Ion channel involvement in the temperature-sensitive response of the rabbit corneal endothelial cell resting membrane potential. J Membr Biol. 1993 Jul; 135(1):61-71.
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43. Farrugia G, Irons WA, Rae JL, Sarr MG, Szurszewski JH. Activation of whole cell currents in isolated human jejunal circular smooth muscle cells by carbon monoxide. Am J Physiol. 1993 Jun; 264(6 Pt 1):G1184-9.
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44. Farrugia G, Rae J. Effect of volume changes on a potassium current in rabbit corneal epithelial cells. Am J Physiol. 1993 May; 264(5 Pt 1):C1238-45.
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45. O'Grady SM, Cooper KE, Rae JL. Regulation of a voltage-dependent, calcium-activated K conductance by cyclic GMP in dissociated flounder enterocytes. Journal of Comparative Physiology - B, Biochemical, Systemic, & Environmental Physiology. 1993; 163(7):581-6.
46. Cooper K, Watsky M, Rae JL. Potassium currents from isolated frog lens epithelia cells. Exp Eye Res. 1992 Dec; 55:861-868.
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47. Farrugia G, Rae JL. Regulation of a potassium-selective current in rabbit corneal epithelium by cyclic GMP, carbachol and diltiazem. J Membr Biol. 1992 Jul; 129(1):99-107.
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48. Rae JL, Farrugia G. Whole-cell potassium current in rabbit corneal epithelium activated by fenamates. J Membr Biol. 1992 Jul; 129(1):81-97.
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49. Watsky MA, Rae JL. Dye coupling in the corneal endothelium: effects of ouabain and extracellular calcium removal. Cell & Tissue Research. 1992 Jul; 269(1):57-63.
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50. Watsky MA, Cooper K, Rae JL. Transient outwardly rectifying potassium channel in the rabbit corneal endothelium. J Membr Biol. 1992 Jun; 128(2):123-32.
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51. Watsky MA, Rae JL. Initial characterization of whole-cell currents from freshly dissociated corneal keratocytes. Curr Eye Res. 1992 Feb; 11(2):127-34.
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52. Rae JL, Levis RA. Glass technology for patch clamp electrodes. Methods Enzymol. 1992; 207:66-92.
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53. Rae JL, Dewey J, Rae S. The large conductance potassium ion channel of rabbit corneal epithelium is blocked by quinidine. Invest Ophthalmol Vis Sci. 1992; 33:286-90.
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54. Rae JL, Levis RA. A method for exceptionally low noise single channel recordings. Pflugers Arch. 1992; 420:618-20.
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55. Rae JL, Levis RA. A technique for ultra low noise single-channel recording using an Axopatch 200A, quartz pipettes, and silicone fluid. Axobits. 1992; 11:9-12.
56. Rae JL, Mathias RT, Cooper K, Baldo G. Divalent cation effects on lens conductance and stretch-activated cation channels. Exp Eye Res. 1992; 55:135-44.
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57. Rae JL, Rae S. Whole-cell currents from nonculturedhuman lens epithelium. Invest Ophthalmol. 1992; 33(7):2262-8.
58. Levis RA, Rae JL. Construction a patch clamp setup. Methods Enzymol. 1992; 207:14-66.
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59. Mathias RT, Riquelme G, Rae JL. Cell to cell communication and pH in the frog lens. J Gen Physiol. 1991 Dec; 98(6):1085-103.
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60. Rae J, Cooper K, Gates P, Watsky M. Low access resistance perforated patch recordings using amphotericin B. J Neurosci Methods. 1991 Mar; 37(1):15-26.
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61. O'Grady SM, Cooper KE, Rae JL. Cyclic GMP regulation of a voltage-activated K channel in dissociated enterocytes. Am J Physiol. 1991; 124:159-67.
62. Rae JL. Physiology of the lens 1-14 in:. Duane's Clinical Ophthalmology Tasman W Haeger EA, Editors JB Lippincott Company, 1991.
63. Rae JL, Fernandez J. Perforated patch recordings in physiology. NIPS. 1991; 6:273-7.
64. Rae JL. Perforated-patch recording techniques. Axobits. 1991; 8:6-10.
65. Watsky MA, Rae JL. Resting voltage measurements of the rabbit corneal endothelium using patch-current clampo techiniques. Invest Ophthalmol Vis Sci. 1991; 32:106-11.
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66. Rae JL, Dewey J, Rae JS, Cooper K. A maxi calcium-activated potassium channel from chick lens epithelium. Curr Eye Res. 1990 Sep; 9(9):847-61.
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67. Rae JL, Dewey J, Rae S, Nesler M, Cooper K. Single potassium channels in corneal epithelium. Invest Ophthalmol Vis Sci (9):1799-1809 1990; 1990:31.
68. Cooper K, Gates P, Rae JL, Dewey J. Electroscopy of cultured human lens epithelial cells. J Membr Biol. 1990; 117:285-98.
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69. Rae JL, Cooper K. New techniques for the study of lens electrophysiology. Exp Eye Res. 1990; 50:603-14.
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70. Rae JL, Dewey J, Cooper K, Gates P. Potassium channel in rabbit corneal endothelium activated by external anions. J Membr Biol 1990; 114:29-36. J Membr Biol. 1990; 114:29-36.
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71. Rae JL, Dewey J, Cooper K, Gates P. A non-selective cation channel in rabbit corneal endothelium activated by internal calcium and inhibited by internal ATP. Exp Eye Res. 1990; 50:373-84.
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72. Cooper K, Rae JL, Gates P. Membrane and junctional properties of dissociaed frog lens epithelial cells. J Membr Biol. 1989; 11:215-27.
73. Gates P, Cooper K, Rae JL, Eisenberg RS. Predictions of diffusion models for one-ion membrane channels. Prog Biophys Molec Biol. 1989; 53:153-96.
74. Rae JL, Cooper KE. Potassium channels in chick lens epithelium change with maturation. Lens and Eye Toxicity Research. 1989; 6:833-43.
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75. Rae JL, Dewey J, Cooper K. Properties of single potassium-selective ionic channels from the apical membrane of rabbit corneal endothelium. Exp Eye Res. 1989; 49:591-609.
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76. Rae JL, Lewno AW, Cooper K, Gates P. Dye and electrical coupling between cells of the rabbit corneal endothelium. Curr Eye Res. 1989; 8:859-69.
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