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Publications - Gianrico Farrugia, M.D.

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  1. McElhiney J, Lohse MR, Arora AS, Peloquin JM, Geno DM, Kuntz MM, Enders FB, Fredericksen M, Abdalla AA, Khan Y, Talley NJ, Diehl NN, Beebe TJ, Harris AM, Farrugia G, Graner DE, Murray JA, Locke GR 3rd, Grothe RM, Crowell MD, Francis DL, Grudell AM, The Mayo Dysphagia Questionnaire-30: Documentation of Reliability and Validity of a Tool for Interventional Trials in Adults with Esophageal Disease. Dysphagia 2009 Oct 24. [Epub ahead of print]
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  2. Linden DR, Levitt MD, Farrugia G, Szurszewski JH. Endogenous Production of H(2)S in the Gastrointestinal Tract: Still in Search of a Physiological Function. Antioxid Redox Signal 2009 Sep 21. [Epub ahead of print]
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  3. Wouters MM, Roeder JL, Tharayil VS, Stanich JE, Strege PR, Lei S, Bardsley MR, Ordog T, Gibbons SJ, Farrugia G. Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. J Biol Chem 2009 Aug 7; 284(32):21177-84. Epub 2009 Jun 16.
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  4. Wouters MM, Roeder JL, Tharayil VS, Stanich JE, Strege PR, Lei S, Bardsley MR, Ordog T, Gibbons SJ, Farrugia G. Protein kinase C gamma mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. J Biol Chem 2009 Aug 7; 284(32):21177-84.
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  5. Bernard CE, Gibbons SJ, Gomez-Pinilla PJ, Lurken MS, Schmalz PF, Roeder JL, Linden D, Cima RR, Dozois EJ, Larson DW, Camilleri M, Zinsmeister AR, Pozo MJ, Hicks GA, Farrugia G. Effect of age on the enteric nervous system of the human colon. Neurogastroenterol Motil 2009 Jul; 21(7):746-e46. Epub 2009 Feb 08.
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  6. Kraichely RE, Farrugia G, Pittock SJ, Castell DO, Lennon VA. Neural Autoantibody Profile of Primary Achalasia. Dig Dis Sci 2009 Jun 05. [Epub ahead of print]
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  7. Gomez-Pinilla PJ, Gibbons SJ, Bardsley MR, Lorincz A, Pozo MJ, Pasricha PJ, de Rijn MV, West RB, Sarr MG, Kendrick ML, Cima RR, Dozois EJ, Larson DW, Ordog T, Farrugia G. Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol 2009 Jun; 296(6):G1370-81 Epub 2009 Apr 16.
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  8. Gomez-Pinilla PJ, Gibbons SJ, Bardsley MR, Lorincz A, Pozo MJ, Pasricha PJ, Van de Rijn M, West RB, Sarr MG, Kendrick ML, Cima RR, Dozois EJ, Larson DW, Ordog T, Farrugia G. Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol 2009 Jun; 296(6):G1370-81. Epub 2009 Apr 16.
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  9. Gomez-Pinilla PJ, Gibbons SJ, Bardsley MR, Lorincz A, Pozo MJ, Pasricha PJ, Van de Rijn M, West RB, Sarr MG, Kendrick ML, Cima RR, Dozois EJ, Larson DW, Ordog T, Farrugia G. Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol 2009 Apr 16. [Epub ahead of print]
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  10. Kraichely RE, Strege PR, Sarr MG, Kendrick ML, Farrugia G. Lysophosphatidyl choline modulates mechanosensitive L-type Ca2+ current in circular smooth muscle cells from human jejunum. Am J Physiol Gastrointest Liver Physiol 2009 Apr; 296(4):G833-9. Epub 2009 Jan 29.
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  11. Garrity MM, Gibbons SJ, Smyrk TC, Vanderwinden JM, Gomez-Pinilla PJ, Nehra A, Borg M, Farrugia G. Diagnostic challenges of motility disorders: optimal detection of CD117+ interstitial cells of Cajal. Histopathology 2009 Feb; 54(3):286-94.
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  12. Saito YA, Strege PR, Tester DJ, Locke GR 3rd, Talley NJ, Bernard CE, Rae JL, Makielski JC, Ackerman MJ, Farrugia G. Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy. Am J Physiol Gastrointest Liver Physiol 2009 Feb; 296(2):G211-8. Epub 2008 Dec 04.
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  13. Gibbons SJ, De Giorgio R, Pellegrini MS, Garrity-Park MM, Miller SM, Schmalz PF, Young-Fadok TM, Larson DW, Dozois EJ, Camilleri M, Stanghellini V, Szurszewski JH, Farrugia G. Apoptotic cell death of human interstitial cells of Cajal. Neurogastroenterol Motil 2009 Jan; 21(1):85-93. Epub 2008 Sep 16.
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  14. Gibbons SJ, De Giorgio R, Pellegrini MS, Garrity-Park MM, Miller SM, Schmalz PF, Young-Fadok TM, Larson DW, Dozois EJ, Camilleri M, Stanghellini V, Szurszewski JH, Farrugia G. Apoptotic cell death of human interstitial cells of Cajal. Neurogastroenterol Motil 2009 Jan; 21(1):85-93 Epub 2008 Sep 16.
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  15. Gibbons SJ, De Giorgio R, Pellegrini MS, Garrity-Park MM, Miller SM, Schmalz PF, Young-Fadok TM, Larson DW, Dozois EJ, Camilleri M, Stanghellini V, Szurszewski JH, Farrugia G. Apoptotic cell death of human interstitial cells of Cajal. Neurogastroenterol Motil 2009 Jan; 21(1):85-93. Epub 2008 Sep 16.
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  16. Gibbons SJ, Strege PR, Lei S, Roeder JL, Mazzone A, Ou Y, Rich A, Farrugia G. The alpha1H Ca2+ Channel Subunit is Expressed in Mouse Jejunal Interstitial Cells of Cajal and Myocytes. J Cell Mol Med 2008 Dec 24. [Epub ahead of print]
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  17. Choi KM, Gibbons SJ, Nguyen TV, Stoltz GJ, Lurken MS, Ordog T, Szurszewski JH, Farrugia G. Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis. Gastroenterology 2008 Dec; 135(6):2055-64, 2064.e1-2. Epub 2008 Sep 11.
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  18. Farrugia G. Ion channels as targets for treatment of gastrointestinal motility disorders. Eur Rev Med Pharmacol Sci 2008 Aug; 12 Suppl 1:135.
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  19. Linden DR, Sha L, Mazzone A, Stoltz GJ, Bernard CE, Furne JK, Levitt MD, Farrugia G, Szurszewski JH. Production of the gaseous signal molecule hydrogen sulfide in mouse tissues. J Neurochem 2008 Aug; 106(4):1577-85. Epub 2008 May 29.
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  20. Rajan E, Gostout CJ, Lurken MS, Talley NJ, Locke GR, Szarka LA, Sumiyama K, Bakken TA, Stoltz GJ, Knipschield MA, Farrugia G. Endoscopic "no hole" full-thickness biopsy of the stomach to detect myenteric ganglia. Gastrointest Endosc 2008 Aug; 68(2):301-7. Epub 2008 Feb 11.
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  21. Ueda K, Valdivia C, Medeiros-Domingo A, Tester DJ, Vatta M, Farrugia G, Ackerman MJ, Makielski JC. Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. Proc Natl Acad Sci U S A 2008 Jul 8; 105(27):9355-60. Epub 2008 Jun 30.
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  22. Mazzone A, Strege PR, Tester DJ, Bernard CE, Faulkner G, De Giorgio R, Makielski JC, Stanghellini V, Gibbons SJ, Ackerman MJ, Farrugia G. A mutation in telethonin alters Nav1.5 function. J Biol Chem 2008 Jun 13; 283(24):16537-44. Epub 2008 Apr 11.
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  23. Kashyap P, Farrugia G. Enteric autoantibodies and gut motility disorders. Gastroenterol Clin North Am 2008 Jun; 37(2):397-410, vi-vii.
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  24. Farrugia G. Interstitial cells of Cajal in health and disease. Neurogastroenterol Motil 2008 May; 20 Suppl 1:54-63.
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  25. Miller SM, Narasimhan RA, Schmalz PF, Soffer EE, Walsh RM, Krishnamurthi V, Pasricha PJ, Szurszewski JH, Farrugia G. Distribution of interstitial cells of Cajal and nitrergic neurons in normal and diabetic human appendix. Neurogastroenterol Motil 2008 Apr; 20(4):349-57. Epub 2007 Dec 07.
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  26. Rajan E, Gostout CJ, Lurken MS, Talley NJ, Locke GR, Szarka LA, Levy MJ, Sumiyama K, de la Mora-Levy JG, Bakken TA, Stoltz GJ, Knipschield MA, Farrugia G. Evaluation of endoscopic approaches for deep gastric-muscle-wall biopsies: what works? Gastrointest Endosc 2008 Feb; 67(2):297-303. Epub 2007 Oct 29.
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  27. Mariani A, Camilleri M, Petersen IA, Ward EM, Farrugia G, Kelly DG, Podratz KC. Audit of suspected chronic intestinal pseudo-obstruction in patients with gynecologic cancer. Eur J Gynaecol Oncol 2008; 29(6):578-82.
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  28. Pasricha PJ, Pehlivanov ND, Gomez G, Vittal H, Lurken MS, Farrugia G. Changes in the gastric enteric nervous system and muscle: a case report on two patients with diabetic gastroparesis. BMC Gastroenterol 2008; 8:21. Epub 2008 May 30.
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  29. Choi KM, Zhu J, Stoltz GJ, Vernino S, Camilleri M, Szurszewski JH, Gibbons SJ, Farrugia G. Determination of gastric emptying in nonobese diabetic mice. Am J Physiol Gastrointest Liver Physiol 2007 Nov; 293(5):G1039-45. Epub 2007 Sep 20.
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  30. Wouters MM, Gibbons SJ, Roeder JL, Distad M, Ou Y, Strege PR, Szurszewski JH, Farrugia G. Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors. Gastroenterology 2007 Sep; 133(3):897-906.
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  31. Mazzone A, Farrugia G. Evolving concepts in the cellular control of gastrointestinal motility: neurogastroenterology and enteric sciences. Gastroenterol Clin North Am 2007 Sep; 36(3):499-513, vii.
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  32. Sha L, Farrugia G, Harmsen WS, Szurszewski JH. Membrane potential gradient is carbon monoxide-dependent in mouse and human small intestine. Am J Physiol Gastrointest Liver Physiol 2007 Aug; 293(2):G438-45. Epub 2007 May 17.
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  33. Wouters MM, Farrugia G, Schemann M. 5-HT receptors on interstitial cells of Cajal, smooth muscle and enteric nerves. Neurogastroenterol Motil 2007 Aug; 19(Suppl 2):5-12.
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  34. Choi KM, Gibbons SJ, Roeder JL, Lurken MS, Zhu J, Wouters MM, Miller SM, Szurszewski JH, Farrugia G. Regulation of interstitial cells of Cajal in the mouse gastric body by neuronal nitric oxide. Neurogastroenterol Motil 2007 Jul; 19(7):585-95.
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  35. Vittal H, Farrugia G, Gomez G, Pasricha PJ. Mechanisms of disease: the pathological basis of gastroparesis--a review of experimental and clinical studies. Nat Clin Pract Gastroenterol Hepatol 2007 Jun; 4(6):336-46.
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  36. Kraichely RE, Farrugia G. Mechanosensitive ion channels in interstitial cells of Cajal and smooth muscle of the gastrointestinal tract. Neurogastroenterol Motil 2007 Apr; 19(4):245-52.
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  37. Rich A, Leddon SA, Hess SL, Gibbons SJ, Miller S, Xu X, Farrugai G. Kit-like immunoreactivity in the zebrafish gastrointestinal tract reveals putative ICC. Dev Dyn 2007 Mar; 236(3):903-11.
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  38. Strege PR, Mazzone A, Kraichely RE, Sha L, Holm AN, Ou Y, Lim I, Gibbons SJ, Sarr MG, Farrugia G. Species dependent expression of intestinal smooth muscle mechanosensitive sodium channels. Neurogastroenterol Motil 2007 Feb; 19(2):135-43.
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  39. Xue L, Camilleri M, Locke GR 3rd, Schuurkes JA, Meulemans A, Coulie BJ, Szurszewski JH, Farrugia G. Serotonergic modulation of murine fundic tone. Am J Physiol Gastrointest Liver Physiol 2006 Dec; 291(6):G1180-6. Epub 2006 Jul 27.
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  40. Locke GR 3rd, Ackerman MJ, Zinsmeister AR, Thapa P, Farrugia G. Gastrointestinal symptoms in families of patients with an SCN5A-encoded cardiac channelopathy: evidence of an intestinal channelopathy. Am J Gastroenterol 2006 Jun; 101(6):1299-304.
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  41. Abell TL, Bernstein RK, Cutts T, Farrugia G, Forster J, Hasler WL, McCallum RW, Olden KW, Parkman HP, Parrish CR, Pasricha PJ, Prather CM, Soffer EE, Twillman R, Vinik AI. Treatment of gastroparesis: a multidisciplinary clinical review. Neurogastroenterol Motil 2006 Apr; 18(4):263-83.
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  42. Perri RE, Langer DA, Chatterjee S, Gibbons SJ, Gadgil J, Cao S, Farrugia G, Shah VH. Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation. Am J Physiol Gastrointest Liver Physiol 2006 Mar; 290(3):G535-42. Epub 2005 Nov 03.
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  43. Xue L, Locke GR, Camilleri M, Schuurkes JA, Meulemans A, Coulie BJ, Szurszewski JH, Farrugia G. Effect of modulation of serotonergic, cholinergic, and nitrergic pathways on murine fundic size and compliance measured by ultrasonomicrometry. Am J Physiol Gastrointest Liver Physiol 2006 Jan; 290(1):G74-82. Epub 2005 Sep 15.
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  44. Wouters MM, Farrugia G. Pathophysiology of neurogastroenterological disorders: GI motility and sensory disorders. Pract Gastroenterol 2006; 30(10):15-34.
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  45. Kraichely RE, Farrugia G. Achalasia: physiology and etiopathogenesis. Dis Esophagus 2006; 19(4):213-23.
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  46. Strege PR, Bernard CE, Ou Y, Gibbons SJ, Farrugia G. Effect of mibefradil on sodium and calcium currents. Am J Physiol Gastrointest Liver Physiol 2005 Aug; 289(2):G249-53.
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  47. Lim I, Gibbons SJ, Lyford GL, Miller SM, Strege PR, Sarr MG, Chatterjee S, Szurszewski JH, Shah VH, Farrugia G. Carbon monoxide activates human intestinal smooth muscle L-type Ca2+ channels through a nitric oxide-dependent mechanism. Am J Physiol Gastrointest Liver Physiol 2005 Jan; 288(1):G7-14.
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  48. Hanani M, Farrugia G, Komuro T. Intercellular coupling of interstitial cells of cajal in the digestive tract. Int Rev Cytol 2005; 242:249-82.
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  49. Matsuda NM, Miller SM, Sha L, Farrugia G, Szurszewski JH. Mediators of non-adrenergic non-cholinergic inhibitory neurotransmission in porcine jejunum. Neurogastroenterol Motil 2004 Oct; 16(5):605-12.
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  50. Gibbs CM, Nichols FC, Kasperbauer JL, Jensen EA, Farrugia G. Meal-induced dysphagia and otalgia secondary to a pyriform sinus fistula. Dig Dis Sci 2004 Sep; 49(9):1560-2.
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  51. Gibbons SJ, Farrugia G. The role of carbon monoxide in the gastrointestinal tract. J Physiol 2004 Apr 15; 556(2):325-36.
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  52. Szurszewski JH, Farrugia G. Carbon monoxide is an endogenous hyperpolarizing factor in the gastrointestinal tract. Neurogastroenterol Motil 2004 Apr; 16(Suppl 1):81-5.
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  53. Strege PR, Evangelista S, Lyford GL, Sarr MG, Farrugia G. Otilonium bromide inhibits calcium entry through L-type calcium channels in human intestinal smooth muscle. Neurogastroenterol Motil 2004 Apr; 16(2):167-73.
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  54. Shah V, Lyford G, Gores G, Farrugia G. Nitric oxide in gastrointestinal health and disease. Gastroenterology 2004 Mar; 126(3):903-13.
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  55. Gonzalez-Michaca L, Farrugia G, Croatt AJ, Alam J, Nath KA. Heme: a determinant of life and death in renal tubular epithelial cells. Am J Physiol Renal Physiol 2004 Feb 1; 286(2):F370-7.
  56. Strege PR, Ou YJ, Sha L, Rich A, Gibbons SJ, Szurszewski JH, Sarr MG, Farrugia G. Sodium current in human intestinal interstitial cells of Cajal. Am J Physiol Gastrointest Liver Physiol 2003 Dec 1; 285(6):G1111-21.
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  57. Kobilo T, Szurszewski JH, Farrugia G, Hanani M. Coupling and innervation patterns of interstitial cells of Cajal in the deep muscular plexus of the guinea-pig. Neurogastroenterol Motil 2003 Dec; 15(6):635-41.
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  58. Gibbons SJ, Rich A, Distad MA, Miller SM, Schmalz PF, Szurszewski JH, Sha L, Blume-Jensen P, Farrugia G. Kit/stem cell factor receptor-induced phosphatidylinositol 3 '-kinase signalling is not required for normal development and function of interstitial cells of Cajal in mouse gastrointestinal tract. Neurogastroenterol Motil 2003 Dec; 15(6):643-53.
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  59. Lyford GL, Farrugia G. Ion channels in gastrointestinal smooth muscle and interstitial cells of Cajal. Current Opinion in Pharmacology 2003 Dec; 3(6):583-7.
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  60. Farrugia G, Lei S, Lin X, Miller SM, Nath KA, Ferris CD, Levitt M, Szurszewski JH. A major role for carbon monoxide as an endogenous hyperpolarizing factor in the gastrointestinal tract. Proc Natl Acad Sci U S A 2003 Jul 8; 100(14):8567-70.
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  61. Feldstein AE, Miller SM, El-Youssef M, Rodeberg D, Lindor NM, Burgart LJ, Szurszewski JH, Farrugia G. Chronic intestinal pseudoobstruction associated with altered interstitial cells of Cajal networks. J Pediatr Gastroenterol Nutr 2003 Apr; 36(4):492-7.
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  62. Rich A, Miller SM, Gibbons SJ, Malysz J, Szurszewski JH, Farrugia G. Local presentation of Steel factor increases expression of c-kit immunoreactive interstitial cells of Cajal in culture. Am J Physiol Gastrointest Liver Physiol 2003 Feb; 284(2):G313-20.
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  63. Ou YJ, Strege P, Miller SM, Makielski J, Ackerman M, Gibbons SJ, Farrugia G. Syntrophin gamma 2 regulates SCN5A Gating by a PDZ domain-mediated interaction. J Biol Chem 2003 Jan 17; 278(3):1915-23.
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  64. Strege PR, Holm AN, Rich A, Miller SM, Ou YJ, Sarr MG, Farrugia G. Cytoskeletal modulation of sodium current in human jejunal circular smooth muscle cells. Am J Physiol Cell Physiol 2003 Jan; 284(1):C60-6.
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  65. Malysz J, Farrugia G, Ou YJ, Szurszewski JH, Nehra A, Gibbons SJ. The Kv2.2 alpha subunit contributes to delayed rectifier K+ currents in myocytes from rabbit corpus cavernosum. J Androl 2002 Nov-Dec; 23(6):899-910.
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  66. Lyford GL, He CL, Soffer E, Hull TL, Strong SA, Senagore AJ, Burgart LJ, Young-Fadok T, Szurszewski JH, Farrugia G. Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation. Gut 2002 Oct; 51(4):496-501.
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  67. Ou Y, Gibbons SJ, Miller SM, Strege PR, Rich A, Distad MA, Ackerman MJ, Rae JL, Szurszewski JH, Farrugia G. SCN5A is expressed in human jejunal circular smooth muscle cells. Neurogastroenterol Motil 2002 Oct; 14(5):477-86.
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  68. Lyford GL, Strege PR, Shepard A, Ou YJ, Ermilov L, Miller SM, Gibbons SJ, Rae JL, Szurszewski JH, Farrugia G. alpha(1C) (Ca(v)1.2) L-type calcium channel mediates mechanosensitive calcium regulation. Am J Physiol Cell Physiol 2002 Sep; 283(3):C1001-8.
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  69. Pardi DS, Miller SM, Miller DL, Burgart LJ, Szurszewski JH, Lennon VA, Farrugia G. Paraneoplastic dysmotility: Loss of interstitial cells of Cajal. Am J Gastroenterol 2002 Jul; 97(7):1828-33.
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  70. Rich A, Hanani M, Ermilov LG, Malysz J, Belzer V, Szurszewski JH, Farrugia G. Physiological study of interstitial cells of Cajal identified by vital staining. Neurogastroenterol Motil 2002 Apr; 14(2):189-96.
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  71. Holm AN, Rich A, Miller SM, Strege P, Ou YJ, Gibbons SJ, Sarr MG, Szurszewski JH, Rae JL, Farrugia G. Sodium current in human jejunal circular smooth muscle cells. Gastroenterology 2002 Jan; 122(1):178-87.
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  72. Malysz J, Gibbons SJ, Miller SM, Gettman M, Nehra A, Szurszewski JH, Farrugia G. Potassium outward currents in freshly dissociated rabbit corpus cavernosum myocytes. J Urol 2001 Sep; 166(3):1167-77.
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  73. Zyromski NJ, Duenes JA, Kendrick ML, Balsiger BM, Farrugia G, Sarr MG. Mechanism mediating nitric oxide-induced inhibition in human jejunal longitudinal smooth muscle. Surgery 2001 Sep; 130(3):489-96.
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  74. He CL, Soffer EE, Ferris CD, Walsh RM, Szurszewski JH, Farrugia G. Loss of interstitial cells of Cajal and inhibitory innervation in insulin-dependent diabetes. Gastroenterology 2001 Aug; 121(2):427-34.
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  75. Simopoulos DN, Gibbons SJ, Malysz J, Szurszewski JH, Farrugia G, Ritman EL, Moreland RB, Nehra A. Corporeal structure and vascular micro architecture with x-ray micro computerized tomography in normal and diabetic rabbits: histopathological correlation. J Urol 2001 May; 165(5):1776-82.
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  76. Miller SM, Reed D, Sarr MG, Farrugia G, Szurszewski JH. Haem oxygenase in enteric nervous system of human stomach and jejunum and co-localization with nitric oxide synthase. Neurogastroenterol Motil 2001 Apr; 13(2):121-31.
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  77. Holm AN, Rich A, Sarr MG, Farrugia G. Whole cell current and membrane potential regulation by a human smooth muscle mechanosensitive calcium channel. Am J Physiol Gastrointest Liver Physiol 2000 Dec; 279(6):G1155-61.
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  78. Vernino S, Low PA, Fealey RD, Stewart JD, Farrugia G, Lennon VA. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N Engl J Med 2000 Sep 21; 343(12):847-55.
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  79. Xue L, Farrugia G, Szurszewski JH. Effect of exogenous ATP on canine jejunal smooth muscle. Am J Physiol Gastrointest Liver Physiol 2000 May; 278(5):G725-33.
  80. Xue L, Farrugia G, Miller SM, Ferris CD, Snyder SH, Szurszewski JH. Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: evidence from genomic deletion of biosynthetic enzymes. Proc Natl Acad Sci U S A 2000 Feb 15; 97(4):1851-5.
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  81. He CL, Burgart L, Wang L, Pemberton J, Young-Fadok T, Szurszewski J, Farrugia G. Decreased interstitial cell of Cajal volume in patients with slow-transit constipation. Gastroenterology 2000 Jan; 118(1):14-21.
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  82. Balsiger BM, Duenes JA, Ohtani N, Shibata C, Farrugia G, Anding WJ, Sarr MG. Nitric oxide pathways in circular muscle of the rat jejunum before and after small bowel transplantation. J Gastrointest Surg 2000 Jan-Feb; 4(1):86-92.
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  83. Miller SM, Sha L, Schmalz PF, Farrugia G, Benarroch EE, Berthoud H, Szurszewski JH. Distribution of leptin receptors in peripheral autonomic ganglia. Autonomic Neuroscience: Basic and Clinical 2000; 82:10-11.
  84. Farrugia G, Szurszewski JH. Heme oxygenase, carbon monoxide, and interstitial cells of Cajal. Microscopy Research & Technique 1999 Dec 1; 47(5):321-4.
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  85. Farrugia G, Holm AN, Rich A, Sarr MG, Szurszewski JH, Rae JL. A mechanosensitive calcium channel in human intestinal smooth muscle cells. Gastroenterology 1999 Oct; 117(4):900-5.
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  86. Murr MM, Balsiger BM, Farrugia G, Sarr MG. Role of nitric oxide, vasoactive intestinal polypeptide, and ATP in inhibitory neurotransmission in human jejunum. J Surg Res 1999 Jun 1; 84(1):8-12.
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  87. Xue L, Farrugia G, Sarr MG, Szurszewski JH. ATP is a mediator of the fast inhibitory junction potential in human jejunal circular smooth muscle. Am J Physiol 1999 Jun; 276(6 Pt 1):G1373-9.
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  88. Rich A, Farrugia G, Rae JL. Effects of melatonin on ionic currents in cultured ocular tissues. Am J Physiol 1999 Apr; 276(4 Pt 1):C923-9.
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  89. Skok VI, Farrugia G, Ermilov LG, Miller SM, Szurszewski JH. Patch-clamp recordings of membrane currents evoked during natural synaptic activity in sympathetic neurons. Neuroscience 1998 Nov; 87(2):509-17.
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  90. Vella A, Farrugia G. D-lactic acidosis: pathologic consequence of saprophytism. Mayo Clin Proc 1998 May; 73(5):451-6.
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  91. Farrugia G, Miller SM, Rich A, Liu X, Maines MD, Rae JL, Szurszewski JH. Distribution of heme oxygenase and effects of exogenous carbon monoxide in canine jejunum. Am J Physiol Gastrointest Liver Physiol 1998 Feb; 274(2):G 350-G 358.
  92. Miller SM, Farrugia G, Schmalz PF, Ermilov LG, Maines MD, Szurszewski JH. Heme oxygenase 2 is present in interstitial cell networks of the mouse small intestine. Gastroenterology 1998 Feb; 114(2):239-44.
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  93. Farrugia G, Nitecki S, Harty GJ, Camilleri M, Szurszewski JH. The effect of flufenamic acid on gastrointestinal myoelectrical activity and transit time in dogs. Gut 1998 Feb; 42(2):258-65.
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  94. Xue L, Farrugia G, Szurszewski JH. Effect of exogenous ATP on canine jejunal circular smooth muscle cells. Gastroenterology 1998; 114:A861.
  95. Farrugia G. G-protein regulation of an L-type calcium channel current in canine jejunal circular smooth muscle. J Membr Biol 1997 Nov 1; 160(1):39-46.
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  96. Farrugia G, Macielag MJ, Peeters TL, Sarr MG, Galdes A, Szurszewski JH. Motilin and OHM-11526 activate a calcium current in human and canine jejunal circular smooth muscle. Am J Physiol Gastrointest Liver Physiol 1997 Aug; 273(2):G 404-G 412.
  97. Rich A, Bartling C, Farrugia G, Rae JL. Effects of PH on the potassium current in rabbit corneal epithelial cells. Am J Physiol Cell Physiol 1997 Feb; 272(2):C 744-C 753.
  98. Loftus EV Jr, Farrugia G, Donohue JH, Camilleri M. Duodenal obstruction: diagnosis by gastroduodenal manometry. Mayo Clin Proc 1997 Feb; 72(2):130-2.
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  99. Vella A, Farrugia G. 90-year-old man with fever and melena. Mayo Clin Proc 1996 Dec; 71(12):1205-8.
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  100. Farrugia G. Modulation of ionic currents in isolated canine and human jejunal circular smooth muscle cells by fluoxetine. Gastroenterology 1996 May; 110(5):1438-45.
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  101. Farrugia G, Camilleri M, Whitehead WE. Therapeutic strategies for motility disorders. Medications, nutrition, biofeedback, and hypnotherapy. Gastroenterol Clin North Am 1996 Mar; 25(1):225-46.
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  102. Farrugia G, Rich A, Rae JL, Sarr MG, Szurszewski JH. Calcium currents in human and canine jejunal circular smooth muscle cells. Gastroenterology 1995 Sep; 109(3):707-17.
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  103. Rich A, Farrugia G, Rae JL. Carbon monoxide stimulates a potassium-selective current in rabbit corneal epithelial cells. Am J Physiol 1994 Aug; 267(2 Pt 1):C435-42.
    View PubMed
  104. Farrugia G, Rae JL, Sarr MG, Szurszewski JH. Potassium current in circular smooth muscle of human jejunum activated by fenamates. Am J Physiol 1993 Nov; 265(5 Pt 1):G873-9.
    View PubMed
  105. Farrugia G, Rae JL, Szurszewski JH. Characterization of an outward potassium current in canine jejunal circular smooth muscle and its activation by fenamates. J Physiol (Lond) 1993 Aug; 468:297-310.
    View PubMed
  106. Farrugia G, Irons WA, Rae JL, Sarr MG, Szurszewski JH. Activation of whole cell currents in isolated human jejunal circular smooth muscle cells by carbon monoxide. Am J Physiol 1993 Jun; 264(6 Pt 1):G1184-9.
    View PubMed
  107. Farrugia G, Rae J. Effect of volume changes on a potassium current in rabbit corneal epithelial cells. Am J Physiol 1993 May; 264(5 Pt 1):C1238-45.
    View PubMed
  108. Farrugia G, Rae JL, Szurszewski JH. Characterization of a delayed rectifier in canine jejunal circular smooth muscle and its activation by fenamates. J Physiol 1993; 468:297-310.
    View PubMed
  109. Farrugia G, Rae JL. Regulation of a potassium-selective current in rabbit corneal epithelium by cyclic GMP, carbachol and diltiazem. J Membr Biol 1992 Jul; 129(1):99-107.
    View PubMed
  110. Rae JL, Farrugia G. Whole-cell potassium current in rabbit corneal epithelium activated by fenamates. J Membr Biol 1992 Jul; 129(1):81-97.
    View PubMed
  111. Farrugia G, Kim CH, Grant CS, Zinsmeister AR. Leiomyosarcoma of the stomach: determinants of long-term survival. Mayo Clin Proc 1992 Jun; 67(6):533-6.
    View PubMed
  112. Kim CH, Farrugia G, Farnell MB. High-grade obstruction of the proximal extrahepatic bile duct: an unusual complication of duodenal ulcer disease. Am J Gastroenterol 1991 Dec; 86(12):1826-8.
    View PubMed
  113. Grant CS, Kim CH, Farrugia G, Zinsmeister AR, Goellner JR. Gastric leiomyosarcoma. Prognostic factors and surgical management. Arch Surg 1991 Aug; 126:985-990.
    View PubMed
  114. Spiteri D, Farrugia G, Farrugia D. The attitudes of Maltese medical students to anaesthesia. Acta Anaesthesiologica Melitensia 1985; 1(3):25-7.


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