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Publications - Merry J . Oursler, Ph.D.

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  1. Clowes JA, Eghbali-Fatourechi GZ, McCready L, Oursler MJ, Khosla S, Riggs BL. Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo. Osteoporos Int 2009 May; 20(5):761-9. Epub 2008 Sep 04.
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  2. Pederson L, Ruan M, Westendorf JJ, Khosla S, Oursler MJ. Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate. Proc Natl Acad Sci U S A 2008 Dec 30; 105(52):20764-9. Epub 2008 Dec 15.
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  3. Bradley EW, Ruan MM, Oursler MJ. PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival. J Cell Physiol 2008 Dec; 217(3):752-8.
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  4. Gingery A, Bradley EW, Pederson L, Ruan M, Horwood NJ, Oursler MJ. TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival. Exp Cell Res 2008 Sep 10; 314(15):2725-38.
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  5. Syed FA, Oursler MJ, Hefferanm TE, Peterson JM, Riggs BL, Khosla S. Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women. Osteoporos Int 2008 Sep; 19(9):1323-30. Epub 2008 Feb 15.
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  6. Bradley EW, Ruan MM, Vrable A, Oursler MJ. Pathway crosstalk between Ras/Raf and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival. J Cell Biochem 2008 Jul 1; 104(4):1439-51.
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  7. Hawse JR, Subramaniam M, Monroe DG, Hemmingsen AH, Ingle JN, Khosla S, Oursler MJ, Spelsberg TC. Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain. Mol Endocrinol 2008 Jul; 22(7):1579-95. Epub 2008 May 15.
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  8. Hawse JR, Iwaniec UT, Bensamoun SF, Monroe DG, Peters KD, Ilharreborde B, Rajamannan NM, Oursler MJ, Turner RT, Spelsberg TC, Subramaniam M. TIEG-null mice display an osteopenic gender-specific phenotype. Bone 2008 Jun; 42(6):1025-31. Epub 2008 Mar 04.
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  9. Sanyal A, Hoey KA, Modder UI, Lamsam JL, McCready LK, Peterson JM, Achenbach SJ, Oursler MJ, Khosla S. Regulation of bone turnover by sex steroids in men. J Bone Miner Res 2008 May; 23(5):705-14.
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  10. Bradley EW, Ruan MM, Oursler MJ. Novel pro-survival functions of the Kruppel-like transcription factor Egr2 in promotion of macrophage colony-stimulating factor-mediated osteoclast survival downstream of the MEK/ERK pathway. J Biol Chem 2008 Mar 21; 283(12):8055-64. Epub 2008 Jan 15.
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  11. Rudnik V, Sanyal A, Syed FA, Monroe DG, Spelsberg TC, Oursler MJ, Khosla S. Loss of ERE binding activity by estrogen receptor-alpha alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells. J Cell Biochem 2008 Feb 15; 103(3):896-907.
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  12. Hawse JR, Subramaniam M, Ingle JN, Oursler MJ, Rajamannan NM, Spelsberg TC. Estrogen-TGFbeta cross-talk in bone and other cell types: role of TIEG, Runx2, and other transcription factors. J Cell Biochem 2008 Feb 1; 103(2):383-92.
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  13. Hawse JR, Subramaniam M, Ingle JN, Oursler MJ, Rajamannan NM, Spelsberg TC. Estrogen-TGFbeta cross-talk in bone and other cell types: Role of TIEG, Runx2, and other transcription factors. J Cell Biochem 2008 Feb 1; 103(2):383-92.
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  14. Khosla S, Westendorf JJ, Oursler MJ. Building bone to reverse osteoporosis and repair fractures. J Clin Invest 2008 Feb; 118(2):421-8.
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  15. Sanyal A, Hoey K, Moedder U, Lamsam J, McCready L, Peterson J, Achenbach S, Oursler MJ, Khosla S. Regulation of Bone Turnover by Sex Steroids in Men. JBMR 2008; 23:705-714. Epub December 17, 2007.
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  16. Clowes J, Eghbali-Fatourechi GZ, Ruan M, McCready L, Oursler MJ, Khosla S, Riggs BL. Estrogen Action on Bone Marrow Osteoclast Lineage Cells of Postmenopausal Women Osteoporosis International 2008.
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  17. Syed F, Oursler MJ, Hefferan T, Peterson J, Riggs BL, Khosla S. Effects of Estrogen Therapy on Bone Marrow Adipocytes in Postmenopausal Osteoporotic Women Osteoporosis International 2008.
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  18. Rudnik V, Sanyal A, Syed FA, Monroe DG, Spelsberg TC, Oursler MJ, Khosla S. Loss of ERE Binging Activity By Estrogen Receptor-alpha Alters Basal and Estrogen-Stimulated Bone-Related Gene Expression by Osteoblastic Cells. J Cell Biochem 2008; 103(3):896-907.
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  19. Khosla S, Westendorf JJ, Oursler MJ. Building Bone to Revers Osteoporosis and Repair Fractures. J Clin Invest 2008; 118(2):421-28 Epub 2008.
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  20. Bradley EW, Oursler MJ. Osteoclast culture and resorption assays. Methods Mol Biol 2008; 455:19-35.
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  21. Cicek M, Iwaniec UT, Goblirsch MJ, Vrabel A, Ruan M, Clohisy DR, Turner RR, Oursler MJ. 2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo. Cancer Res 2007 Nov 1; 67(21):10106-11.
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  22. Cicek M, Iwaniec UT, Goblirsch M, Vrabel A, Ruan M, Clohisy DC, Turner R, Oursler MJ. 2-Methoxyestradiol Suppressed Ostolytic Breast Cancer Tumor Progression In Vivo Cancer Research 2007.
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  23. Cicek M, Oursler MJ. Breast cancer bone metastasis and current small therapeutics. Cancer Metastasis Rev 2006 Dec; 25(4):635-44.
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  24. Bensamoun SF, Hawse JR, Subramaniam M, Ilharreborde B, Bassillais A, Benhamou CL, Fraser DG, Oursler MJ, Amadio PC, An KN, Spelsberg TC. TGF beta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture. Bone 2006 Dec; 39(6):1244-51.
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  25. Maran A, Gorny G, Oursler MJ, Zhang M, Shogren KL, Yaszemski MJ, Turner RT. 2-methoxyestradiol inhibits differentiation and is cytotoxic to osteoclasts. J Cell Biochem 2006 Oct 1; 99(2):425-34.
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  26. Lotinun S, Evans GL, Turner RT, Oursler MJ. Deletion of membrane-bound steel factor results in osteopenia in mice. J Bone Miner Res 2005 Apr; 20(4):644-52.
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  27. Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van Deursen JMA, Turner RT, Oursler MJ, Spelsberg TC. TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol Cell Biol 2005 Feb; 25(3):1191-9.
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  28. Oursler MJ, Bradley EW, Elfering SL, Giulivi C. Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis. Am J Physiol Cell Physiol 2005 Jan; 288(1):C156-68.
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  29. Karst M, Gorny G, Galvin RJ, Oursler MJ. Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-beta regulation of osteoclast differentiation. J Cell Physiol 2004 Jul; 200(1):99-106.
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  30. Gorny G, Shaw A, Oursler MJ. IL-6, LIF, and TNF-alpha regulation of GM-CSF inhibition of osteoclastogenesis in vitro. Exp Cell Res 2004 Mar 10; 294(1):149-58.
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  31. Gingery A, Bradley E, Shaw A, Oursler MJ. Phosphatidylinositol 3-kinase coordinately activates the MEK/ERK and AKT/NFkappaB pathways to maintain osteoclast survival. J Cell Biochem 2003 May 1; 89(1):165-79.
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  32. Mizuta H, Sanyal A, Fukumoto T, Fitzsimmons JS, Matsui N, Bolander ME, Oursler MJ, O'Driscoll SW. The spatiotemporal expression of TGF-beta 1 and its receptors during periosteal chondrogenesis in vitro. J Orthop Res 2002 May; 20(3):562-74.
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  33. Sanyal A, Oursler MJ, Clemens VR, Fukumoto T, Fitzsimmons JS, O'Driscoll SW. Temporal expression patterns of BMP receptors and collagen II (B) during periosteal chondrogenesis. J Orthop Res 2002 Jan; 20(1):58-65.
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  34. Gingery A, Oursler MJ. The roles of TGF-beta in metastatic cancer progression in bone. Recent Research Developments in Cancer 2002; 4:13-24.
  35. Pascoe D, Oursler MJ. The Src signaling pathway regulates osteoclast lysosomal enzyme secretion and is rapidly modulated by estrogen. J Bone Miner Res 2001 Jun; 16(6):1028-36.
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  36. Winding B, Misander H, Sveigaard C, Therkildsen B, Jakobsen M, Overgaard T, Oursler MJ, Foged NT. Human breast cancer cells induced angiogenesis, recruitment, and activation of osteoclasts in osteolytic metastasis. Journal of Cancer Research & Clinical Oncology 2000 Nov; 126(11):631-40.
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  37. Winding B, Misander H, Sveigaard C, Therkildsen B, Jakobsen M, Overgaard T, Oursler MJ, Foged NK. Human breast cancer cell-induced angiogenesis, recruitment, and activation of osteoclasts in bone. J Cancer Res Clin Oncol 2000; 126:631-40.
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  38. Shaw A, Oursler MJ. Paracrine regulation of osteoclast activity in metastatic breast cancer. Cancer Research Alert 2000; 1:124-7.
  39. Pederson L, Winding B, Foged NT, Spelsberg TC, Oursler MJ. Identification of breast cancer cell line-derived paracrine factors that stimulate osteoclast activity. Cancer Res 1999 Nov 15; 59(22):5849-55.
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  40. Pederson L, Kremer M, Judd J, Pascoe D, Spelsberg TC, Riggs BL, Oursler MJ. Androgens regulate bone resorption activity of isolated osteoclasts in vitro. Proc Natl Acad Sci U S A 1999 Jan 19; 96(2):505-10.
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  41. Oursler MJ. Mechanisms of steroid action on osteoclasts and osteoblasts. Biochem Soc Trans 1998 Feb; 26(1):33-8.
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  42. Collin-Osdoby P, Li L, Rothe L, Anderson F, Kirsch D, Oursler MJ, Osdoby P. Inhibition of avian osteoclast bone resorption by monoclonal antibody 121F: a mechanism involving the osteoclast free radical system. J Bone Miner Res 1998 Jan; 13(1):67-78.
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  43. Oursler MJ. Estrogen regulation of gene expression in osteoblasts and osteoclasts. Crit Rev Eukaryot Gene Expr 1998; 8(2):125-40.
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  44. Pederson L, Kremer M, Foged NT, Winding B, Ritchie C, Fitzpatrick LA, Oursler MJ. Evidence of a correlation of estrogen receptor level and avian osteoclast estrogen responsiveness. J Bone Miner Res 1997 May; 12(5):742-52.
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  45. Pederson L, Kremer M, Foged N, Winding B, Ritchie C, Fitzpatrick L, Oursler MJ. Correlation of estrogen receptor level and avian osteoclast estrogen responsiveness. J Bone Miner Res 1997; 12:742-52.
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  46. Clohisy DR, Palkert D, Ramnaraine ML, Pekurovsky I, Oursler MJ. Human breast cancer induces osteoclast activation and increases the number of osteoclasts at sites of tumor osteolysis. J Orthop Res 1996 May; 14(3):396-402.
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  47. Robinson JA, Riggs BL, Spelsberg TC, Oursler MJ. Osteoclasts and transforming growth factor-beta: estrogen-mediated isoform-specific regulation of production. Endocrinology 1996 Feb; 137(2):615-21.
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  48. Robinson JA, Riggs BL, Spelsberg TC, Oursler MJ. Osteoclasts and TGF-beta: estrogen mediated, isoform specific regulation of production. Endocrinology 1996; 137:615-21.
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  49. Subramaniam M, Harris SA, Oursler MJ, Rasmussen K, Riggs BL, Spelsberg TC. Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. Nucleic Acids Res 1995 Dec 11; 23(23):4907-12.
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  50. Schutze N, Oursler MJ, Nolan J, Riggs BL, Spelsberg TC. Zeolite A inhibits osteoclast-mediated bone resorption in vitro. J Cell Biochem 1995 May; 58(1):39-46.
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  51. Kremer M, Judd J, Rifkin B, Auszmann J, Oursler MJ. Estrogen modulation of osteoclast lysosomal enzyme secretion. J Cell Biochem 1995 Feb; 57(2):271-9.
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  52. Subramaniam M, Oursler MJ, Rasmussen K, Riggs BL, Spelsberg TC. TGF-beta regulation of nuclear proto-oncogenes and TGF-beta gene expression in normal human osteoblast-like cells. J Cell Biochem 1995 Jan; 57(1):52-61.
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  53. Collin-Osdoby P, Oursler MJ, Rothe L, Webber D, Anderson F, Osdoby P. Osteoclast 121F antigen expression during osteoblast conditioned medium induction of osteoclast-like cells in vitro: relationship to calcitonin responsiveness, tartrate resistant acid phosphatase levels, and bone resorptive activity. J Bone Miner Res 1995 Jan; 10(1):45-58.
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  54. Collin-Osdoby P, Oursler MJ, Rothe L, Webber D, Anderson F, Osdoby P. Osteoclast 121F antigen induction of osteoclast-like cells in vitro: relationship to calcitonin responsiveness, tartrate resistant acid phosphatase levels, and bone resorptive activity. J Bone Miner Res 1995; 10:45-58.
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  55. Judd J, Kremer M, Oursler MJ. Age dependence of estrogen responsiveness. Calcif Tissue Int 1995; 56 Suppl 1:S25-6.
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  56. Khosla S, Oursler MJ, Schroeder MJ, Eberhardt NL. Transforming growth factor-beta 1 induces growth inhibition of a human medullary thyroid carcinoma cell line despite an increase in steady state c-myc messenger ribonucleic acid levels. Endocrinology 1994 Nov; 135(5):1887-93.
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  57. Oursler MJ, Pederson L, Fitzpatrick L, Riggs BL, Spelsberg T. Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells. Proc Natl Acad Sci U S A 1994 Jun 7; 91(12):5227-31.
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  58. Oursler MJ. Osteoclast synthesis and secretion and activation of latent transforming growth factor beta. J Bone Miner Res 1994 Apr; 9(4):443-52.
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  59. Khosla S, Oursler MJ, Schroeder MJ, Eberhardt NL. TGF-beta1 induces growth inhibition of a human medullary thyroid carcinoma cell line despite an increase in steady state c-myc mRNA levels. Endocrinology 1994; 135:1887-93.
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  60. Sarrel PM, Lufkin EG, Oursler MJ, Keefe D. Estrogen actions in arteries, bone, and brain. Scientific American Science and Medicine 1994; 1(3):44-53.
  61. Oursler MJ, Riggs BL, Spelsberg TC. Glucocorticoid-induced activation of latent transforming growth factor-beta by normal human osteoblast-like cells. Endocrinology 1993 Nov; 133(5):2187-96.
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  62. Oursler MJ, Landers JP, Riggs BL, Spelsberg TC. Oestrogen effects on osteoblasts and osteoclasts. Ann Med 1993 Aug; 25(4):361-71.
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  63. Oursler MJ, Pederson L, Pyfferoen J, Osdoby P, Fitzpatrick L, Spelsberg TC. Estrogen modulation of avian osteoclast lysosomal gene expression. Endocrinology 1993 Mar; 132(3):1373-80.
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  64. Oursler MJ, Riggs BL, Fitzpatrick L, Spelsberg TC. Estrogen action on bone cells: the osteoclasts. Fourth International Symposium on Osteoporosis 1993; 386-91.
  65. Keeting PE, Oursler MJ, Wiegand KE, Bonde SK, Spelsberg TC, Riggs BL. Zeolite A increases proliferation, differentiation, and transforming growth factor beta production in normal adult human osteoblast-like cells in vitro. J Bone Miner Res 1992 Nov; 7(11):1281-9.
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  66. Greenfield EM, Alvarez JI, McLaurine EA, Oursler MJ, Blair HC, Osdoby P, Teitelbaum SL, Ross FP. Avian osteoblast conditioned media stimulate bone resorption by targeting multinucleating osteoclast precursors. Calcif Tissue Int 1992 Oct; 51(4):317-23.
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  67. Keeting PE, Scott RE, Colvard DS, Anderson MA, Oursler MJ, Spelsberg TC, Riggs BL Jr. Development and characterization of a rapidly proliferating, well-differentiated cell line derived from adult human osteoblast-like cells transfected with SV40 large T antigen. J Bone Miner Res 1992 Feb; 7:127-36.
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  68. Osdoby P, Oursler MJ, Pyfferoen J, Riggs BL Jr, Spelsberg TC. The regulation of osteoclast activity. Int Congr Ser 1992; 1002:339-46.
  69. Oursler MJ, Cortese C, Keeting P, Anderson MA, Bonde SK, Riggs BL, Spelsberg TC. Modulation of transforming growth factor-beta production in normal human osteoblast-like cells by 17 beta-estradiol and parathyroid hormone. Endocrinology 1991 Dec; 129(6):3313-20.
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  70. Collin-Osdoby P, Oursler MJ, Webber D, Osdoby P. Osteoclast-specific monoclonal antibodies coupled to magnetic beads provide a rapid and efficient method of purifying avian osteoclasts. J Bone Miner Res 1991 Dec; 6(12):1353-65.
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  71. Oursler MJ, Collin-Osdoby P, Li L, Schmitt E, Osdoby P. Evidence for an immunological and functional relationship between superoxide dismutase and a high molecular weight osteoclast plasma membrane glycoprotein. J Cell Biochem 1991 Aug; 46(4):331-44.
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  72. Oursler MJ, Li L, Osdoby P. Purification and characterization of an osteoclast membrane glycoprotein with homology to manganese superoxide dismutase. J Cell Biochem 1991 Jul; 46(3):219-33.
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  73. Oursler MJ, Collin-Osdoby P, Anderson F, Li L, Webber D, Osdoby P. Isolation of avian osteoclasts: improved techniques to preferentially purify viable cells. J Bone Miner Res 1991 Apr; 6(4):375-85.
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  74. Oursler MJ, Li L, Collin-Osdoby P, Schmitt E, Osdoby, P. Evidence for an immunological relationship between superoxide dismutase and a high molecular weight osteoclast plasma membrane glycoprotein. J Cell Biochem 1991; 46:331-44.
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  75. Oursler MJ, Osdoby P. Characterization of an osteoclast membrane protein related to superoxide dismutase. Excerpta Medica: International Congress Series 1990; 886(10):214-20.
  76. Oursler MJ, Osdoby P. Osteoclast development in marrow cultured in calvaria-conditioned media. Dev Biol 1988 May; 127(1):170-8.
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  77. Osdoby P, Oursler MJ, Salino-Hugg T, Krukowski M. Osteoclast development: the cell surface and the bone environment. Ciba Found Symp 1988; 136:108-24.
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  78. Osdoby P, Krukowski M, Oursler MJ, Salino-Hugg T. The origin, development and regulation of osteoclasts. Bioessays 1987 Jul; 7(1):30-4.
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  79. Oursler MJ, Bell LV, Clevinger B, Osdoby P. Identification of osteoclast-specific monoclonal antibodies. J Cell Biol 1985 May; 100(5):1592-600.
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  80. Richter GW, Velasquez MJ, Shedd R. Ferritin in rat kidneys with specific lesions due to a single dose of lead. Am J Pathol 1979 Mar; 94(3):483-95.
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